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Botany > HEMA 2 LEC - Mature Lymphoid Neoplasms 3 > Flashcards

HEMA 2 LEC - Mature Lymphoid Neoplasms 3 Flashcards

1
Q

• Large atypical cells with pleomorphic nuclei and abundant cytoplasm.

A

Anaplastic Large Cell Lymphoma

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2
Q

• Expression of CD30 antigen and ALK protein

A

Anaplastic Large Cell Lymphoma

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3
Q

• If with fibrosis: anaplastic large cell lymphoma may resemble ____

A

Hodgkin lymphoma

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4
Q

t(2;5)(p23;35) between the ALK and nucleophosmin genes

A

Anaplastic Large Cell Lymphoma

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5
Q

t(2;5)(p23;35)

A

Anaplastic Large Cell Lymphoma

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6
Q

• Pan–T-cell markers (CD3, CD7, CD5): often absent

A

Anaplastic Large Cell Lymphoma

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7
Q

• Proportion of cells are large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei, so-called hallmark cells

A

Anaplastic Large Cell Lymphoma

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8
Q

Cells found in Anaplastic Large Cell Lymphoma

large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei

A

Hallmark cells

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9
Q

• One of the most common lymphomas in the pediatric population (10% to 15% of childhood lymphomas) disseminated nodal disease with constitutional symptoms

A

Anaplastic Large Cell Lymphoma

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10
Q

most important prognostic feature of Anaplastic Large Cell Lymphoma

A

expression of ALK protein

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11
Q

___disease has a favorable prognosis: ALK+ or ALK-

A

ALK+

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12
Q

___disease shows survival rates more comparable to those for peripheral T-cell lymphoma, unspecified: ALK+ or ALK-

A

ALK-

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13
Q

2 categories of Hodgkin lymphoma

A

o Nodular lymphocyte-predominant Hodgkin lymphoma

o Classical Hodgkin lymphoma

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14
Q

• B-cell neoplasm composed of relatively rare neoplastic cells (lymphocytic/histiocytic or “popcorn” cells) scattered within nodules of reactive lymphocytes

A

Nodular lymphocyte-predominant Hodgkin lymphoma

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15
Q

do cells of Nodular lymphocyte-predominant Hodgkin lymphoma show EBV infection

A

No

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16
Q
  • heterogenous group of lymphoid neoplasms derived from the germinal center.
  • presence of relatively few diagnostic neoplastic cells, Reed-Sternberg cells, in a rich reactive background
A

Classical Hodgkin Lymphoma

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17
Q

in the United States and Europe, it is a common form of lymphoma occurring in young adults

A

Classical Hodgkin Lymphoma

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18
Q

subtypes of Classical Hodgkin Lymphoma (4)

A
  1. Nodular sclerosis
  2. Mixed cellularity

  3. Lymphocyte rich

  4. Lymphocyte depleted
19
Q

what cells are present in all subtypes of classical Hodgkin lymphoma

A

reed-sternberg cells

20
Q

large lymphoid cell with a bilobed nucleus or two nuclei with prominent eosinophilic nucleoli and abundant cytoplasm (what cell which is present in classical Hodgkin lymphoma)

A

reed-sternberg cells

21
Q

what cell is pathognmonic for Classical Hodgkin Lymphoma

A

reed-sternberg cells

22
Q

variants of reed-sternberg cells
large mononuclear lymphoid cells with an oval nucleus, thick nuclear membrane, distinct eosinophilic nucleolus, and abundant cytoplasm

A

Hodgkin cells

23
Q

variants of reed-sternberg cells - degenerated or apoptotic cells with a pyknotic nucleus and condensed cytoplasm

A

Mummified cells

24
Q

variants of reed-sternberg cells - occur predominantly in the nodular sclerosis variant of classical Hodgkin lymphoma and are characterized by a lobated nucleus and artifactual retraction of the cytoplasm secondary to formalin fixation. Because of this artifact, the cells appear to be situated in a clear space

A

Lacunar cells

25
Q

which category of hodgkin lymphoma show EBV infection

A

classical hodgkin lymphoma

26
Q

what subtype of classical hodgkin lymphoma

presence of broad collagen bands transecting the lymph node, thickening of the nodal capsule and lacunar cells

A

Nodular sclerosis classical Hodgkin lymphoma

27
Q

most common of all the subtypes of classical Hodgkin lymphoma, accounting for 70% of cases

A

Nodular sclerosis classical Hodgkin lymphoma

28
Q

what subtype of classical hodgkin lymphoma

background cellularity includes small lymphocytes, eosinophils, and histiocytes

A

Nodular sclerosis classical Hodgkin lymphoma

29
Q

what subtype of classical hodgkin lymphoma

• frequency of immunohistochemically demonstrable EBV infection is lowest in this variant

A

Nodular sclerosis classical Hodgkin lymphoma

30
Q

what subtype of classical hodgkin lymphoma
Reed-Sternberg cells and their variants scattered among the diffuse background proliferation of small lymphocytes, histiocytes, eosinophils, neutrophils, and plasma cells.

A

Mixed cellularity classical Hodgkin lymphoma

31
Q

what subtype of classical hodgkin lymphoma
Typical Reed-Sternberg cells, mononuclear Hodgkin cells, and mummified cells are seen; however, lacunar cells are absent.

A

Mixed cellularity classical Hodgkin lymphoma

32
Q

what subtype of classical hodgkin lymphoma

fibrotic bands and capsular thickening are not seen

A

Mixed cellularity classical Hodgkin lymphoma

33
Q

what subtype of classical hodgkin lymphoma

Scattered mononuclear Hodgkin and Reed-Sternberg cells seen along with a vaguely nodular background of small lymphocytes

A

Lymphocyte-rich classical Hodgkin lymphoma

34
Q

what subtype of classical hodgkin lymphoma

Nodules represent remnants of mantle zones and residual germinal centers

A

Lymphocyte-rich classical Hodgkin lymphoma

35
Q

what subtype of classical hodgkin lymphoma

Background cellularity is less heterogeneous

A

Lymphocyte-rich classical Hodgkin lymphoma

36
Q

what subtype of classical hodgkin lymphoma

Uncommon variant of classical Hodgkin lymphoma

A

Lymphocyte-depleted classical Hodgkin lymphoma

37
Q

what subtype of classical hodgkin lymphoma

Predominant in immunodeficient patients

A

Lymphocyte-depleted classical Hodgkin lymphoma

38
Q

what subtype of classical hodgkin lymphoma

Scarcity (paucity) of cells of reactive background

A

Lymphocyte-depleted classical Hodgkin lymphoma

39
Q

what subtype of classical hodgkin lymphoma

Neoplastic Reed-Sternberg cells and their variants are much more frequent
• Cells show evidence of EBV infection

A

Lymphocyte-depleted classical Hodgkin lymphoma

40
Q

only subtype of classical Hodgkin lymphoma which occurs in slightly older population (because majority: young adults)

A

lymphocyte-rich variant

41
Q

only subtype of classical Hodgkin lymphoma which does not involve peripheral lymph node

A

nodular sclerosis

42
Q

subtype of classical Hodgkin lymphoma which shows mediastinal lymphadenopathy

A

nodular sclerosis

43
Q

subtype of classical Hodgkin lymphoma which

with the best prognosis

A

nodular sclerosis

44
Q

subtype of classical Hodgkin lymphoma which is the most aggressive variant of classical Hodgkin lymphoma especially in HIV-positive patients

A

Lymphocyte-depleted Hodgkin lymphoma

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