GPHT LEC - Inflammation Flashcards
A complex reaction to various injurious agents
Inflammation
Consists of vascular responses, migration and activation of leukocytes, and systemic reactions
Inflammation
Unique features of inflammation
◦ Reaction of blood vessels
◦ Accumulation of fluids and electrolytes in extravascular space
components of inflammatory response
vascular and cellular rxn
vascular rxn composed of
vasodilation
increased permeability
cellular rxn composed of
Margination Rolling Adhesion Transmigration Migration
Inflammation is terminated when
the inciting agent is eliminated and the mediators have degenerated.
A rapid response to an injurious agent that aims to rapidly bring mediators of inflammation to the site of injury
acute inflammation
characteristics of acute inflammation
◦ Alterations in blood flow
◦ Increased vascular permeability
◦ Emigration,accumulation,and activation of neutrophils
distinctive feature of acute inflammation
Infiltration by polymorphonuclear cells (neutrophils, eosinophils, basophils)
Hallmark of acute inflammation:
◦ Increased vascular
permeability
Refers to an excess fluid in the interstitial tissue or serous cavities
edema
The escape of fluid, proteins, and blood cells from the vascular system into interstitial tissue or body cavities Two types ◦ ◦ Exudate Transudate
exudation
two types of exudate
high cellularity, sp gr and protein
exudate
two types of exudate
low to none cellularity, sp gr and protein
transudate
An exudate rich in inflammatory cells (leukocytes) and cellular debris
pus
morphologic patterns of acute inflammation
◦ Plasma-like effusion with no cells
Serous
morphologic patterns of acute inflammation
◦ There is abundant protein- rich fluid exudate with a relatively low cellular content
Serous
morphologic patterns of acute inflammation
◦ Early inflammation,heart failure, pleural effusions
Serous
morphologic patterns of acute inflammation
◦ Inflammation of the serous
cavities, such as peritonitis, and inflammation of a synovial joint, acute synovitis
Serous
morphologic patterns of acute inflammation
◦ Vascular dilatation may be apparent to the naked eye
Serous
morphologic patterns of acute inflammation
◦ Contains dying and degenerate neutrophils,proteins,tissue debris, infecting organisms
Serous
morphologic patterns of acute inflammation
◦ The pus may become walled-off by granulation tissue or fibrous
tissue to produce an abscess (a localized collection of pus in a tissue)
Serous
morphologic patterns of acute inflammation
◦ Caused by pyogenic bacteria
Serous
(a localized collection of pus in a tissue)
abscess
If a hollow viscus fills with pus,this is called an
empyema,
accumulation of fluid in body cavities
effusion
morphologic patterns of acute inflammation
Contains large amounts of fibrinogen
fibrinous
morphologic patterns of acute inflammation
◦ Forms thick, sticky meshwork that may cause areas to stick
together
fibrinous
morphologic patterns of acute inflammation
◦ Often seen in acute pericarditis giving the parietal and visceral
pericardium a ‘bread and butter’ appearance.
fibrinous