Sjorns

Question 1

Metabolic or autoimmune? (sjoin the autoimmune)

Answer 1

It is an autoimmune disease that causes the obstruction of the secretory ducts and glands, typically the salivary and lacrimal glands.

Question 2

ETIOLOGY/ PATHOPHYSIOLOGY (connect me with sjorns)

Answer 2

Connective tissue disorder
More common among persons with certain tissue types:
HLA-DRW52, HLA-DR3, and HLA-B8.

Question 3

CLINICAL SX’s of SJOGREN’s - Insufficient tears causes

Answer 3

inflammation and ulceration of the cornea.

Question 4

SJOGREN’S SYNDROME: DIAGNOSTICS (Shirmer is a sjogren)

Answer 4

Tests to confirm KCS: i.e. Schirmer’s test
Tests to quantify xerostomia: i.e whole sialometry and Saxon test.
Salivary gland biopsy
Serologixc testing : Ro/SSA and Lo/SSA, RF, ANA.
MRI: to evaluate salivary glands.

Question 5

TREATMENT of SJOGREN’S

Answer 5

No cure: symptomatic management.
Artificial tears
Salagen for dry mouth
vaginal lubricants

Question 6

Decreased exocrine gland function leads to the “ sicca complex”: a combination of

Answer 6

Dry mouth: Xerostomia
Dry eye: keratoconjunctivis sicca

Question 7

Other glands that can be affected (sjogren’s is a pins)

Answer 7

stomach, pancreas, intestines, vagina.

Question 8

Insufficient saliva decreases

Answer 8

Insufficient saliva decreases digestion, promotes tooth decay, and increases nasal and oral infections, epistaxis.

Question 9

Dry vagina causes

Answer 9

pain during intercourse (dyspareunia)

Question 10

treatment (Chemo for venus)

Answer 10

Low dose chemotherapy can slow the progression of Sjogren’s by suppressing the immune and inflammatory response (Methotrexate, Cytoxan)s

Question 11

steroids? (Venus has plaque)

Answer 11

Corticosteroids, Plaquenil (may slow inflammatory response)

Question 12

sjorns - cause

Answer 12

Exact trigger for SJOGREN’S is not known
A viral trigger is strsongly suspected

Question 13

sjorns in LA