Pharm Week 2 Flashcards
Describe the three phases of drug activity: (think pharmaceuticals)
- Pharmaceutical
- Pharmacokinetic
- Pharmacodynamics
Describe the physiochemical processes mediating drug
action.
Describe the physiochemical processes mediating drug
action.
Explain the client variables that influence the rate and extent of Absorption, Distribution, Metabolism,
and Elimination.
Absorption, Distribution, Metabolism,
and Elimination.
Definitions! Chemical/Generic/Trade name
Definitions! Chemical/Generic/Trade name
drug actions: (recept the enzyme or be nonspecific)
- drug receptor interaction
- drug-enzyme interaction
- nonspecific drug interaction
drug-enzyme interaction
drug-enzyme interaction
nonspecific drug interaction
nonspecific drug interaction
Pharmaceutical - Dosage form determines the rate (not absorption, but close)
drug dissolution (dissolving of solid dosage forms and their absorption from the GI tract). goes from solid and breaks down in gut
🞑 Enteric-coated tablets
🞑 Extended-release form
Pharmacokinetic
Pharmacokinetic
Pharmacokinetic (body kinetetics changes a drug)
The study of what the body does to the drug
- Absorption
- Distribution
- Metabolism
-Excretion
- drug receptor interaction
- drug receptor interaction
Absorption (absorb the bupe into your bloodstream to your sore muscles)
the movement from administration into the bloodstream for distribution to the tissues
Distribution
Distribution
Metabolism,
Metabolism,
elimination
elimination
Use Nursing Assessments to identify unusual
and adverse effects of drug therapy.
Use Nursing Assessments to identify unusual
and adverse effects of drug therapy.
Drugs do not confer any new functions on a
tissue or organ in the body; they only
modify
existing functions.
Drugs in general exert multiple actions rather
than
a single effect.
Drug action results from a physiochemical
interaction between the (just the drug and a specific molecule - makes sense)
drug and a
functionally important molecule in the body
Pharmaceutics (the suits control the dosage and how it affects the body)
the study of how various dosage forms influence the way in which the drug affects the body
Pharmacodynamics involves..(the drug and receptor are dynamic)
drug-receptor relationship.
the mechanism of drug actions in living tissues
Pharmacokinetics is the study of what the…(kinetics is a rush) WHICH includes AD ME
body does to the drug.
- Absorption
- Distribution
- Metabolism
-Excretion
pharmaceutics -Dosage form determines the rate of (not absorption, but close)
drug dissolution (dissolving of solid dosage forms and their absorption from the GI tract).
Enteric-coated tablets
🞑 Extended-release forms
pharmokinetics (kinetics is down with O/P/D)
A drug’s time to Onset of action, time
to Peak effect, and Duration of action
pharmokinetics is the study of what happens to a drug from the time it is put into the body until the (parents are kin)
the parent drug and all metabolites have left the body
pharmacokinetics: absorption - (absoption goes from admin to bloodstream)
Movement of a drug from its site of administration into the bloodstream for distribution to the bioavailability and first pass
absorption (compare theabsportionw/onsetandduration)
A comparison of drug Onsets and Duration of Action by Route of Administration. Fastest is IV - bypasses the liver.
A drug’s route of administration affects the (and types of routes - PET the route)absorption????
the rate and extent of Absorption of that drug
🞑 Enteral (GI tract)
🞑 Parenteral
🞑 Topical
enteral routes
The drug is absorbed into the systemic circulation
through the oral or gastric mucosa or the small
intestine
examples of enteral routes (enteral BROS)
- Oral
- Sublingual
-Buccal
-Rectal (can also be topical)
types of parenteral routes (VAAT D MC)
Intravenous (fastest delivery into the blood circulation)
Intramuscular
Subcutaneous (insulin)
Intradermal
Intraarterial
Intrathecal (in spinal column)
Intraarticular (into joint)
topical route (LEEN RVS are topical) start with skin, then top of head - eyes, etc.)
Skin (including transdermal patches)
Eyes
Ears
Nose
Lungs (inhalation)
Rectum
Vagina
distribution (distribute from the blood to the worksite)
The transport of a drug by the bloodstream to its
site of action
types of distribution (distribute the protein, water, and bbb)
Protein-binding
Water-soluble vs. Fat-soluble
Blood-brain barrier
distribution - Areas of rapid distribution - the basic organs (HLK B rapid)
Heart, Liver, Kidneys, Brain (if you are in trauma, body will wall off heart, lungs and brain - most important)
distribution - Areas of slow distribution (MS F is slow)
Muscle, Skin, Fat
Distribution - A loading dose is administered to…
reach a therapeutic response level rapidly. Maintenance
doses are administered at prescribed intervals to
maintain a therapeutic drug response.
distribution - Maintenance doses are administered at
prescribed intervals to maintain a therapeutic drug response.
metabolism/biotransformation (transform into active)
*The biochemical alteration of a drug into an inactive metabolite, a more soluble compound, a more potent active metabolite, or a less active metabolite
organs involved in metabolism/biotransformation (I’LL SKP biotransformation)
Liver (main organ)
Skeletal muscle
Kidneys
Lungs
Plasma
Intestinal mucosa
Factors that decrease metabolism (metabolism goes down when my heart and kidneys are starving. Also when I’m yellow from acetylate or ketoconazale)
Cardiovascular dysfunction
Renal insufficiency
Starvation
Obstructive jaundice-Yellow skin, eyes,, Liver CA, blocked Bile (also overdose of asprin)
Slow acetylator-Liver can’t detoxify becomes toxic
Ketoconazole therapy- tx for fungus or yeast infections
Factors that increase metabolism (metabolism goes up during BAR PH (ight)
already outlined
excretion is (excrete that drug)
The elimination of drugs from the body
organs involved in excretion (excretion is BBBLEK (bleak) (don’t need to know all of this)
Kidneys (main organ)
Liver
Bowel
🞑 Biliary excretion
🞑 Enterohepatic recirculation
Biliary recycling
half life
The time it takes for one half of the original
amount of a drug to be removed from the body…
A measure of the rate at which a drug is
removed from the body
Most drugs considered to be effectively removed
after about five half-lives
Steady state- constant drug level- 2, 4, 5X 1/2L
bioavailability Refers to the (my percent in bio met the target)
percentage of active drug substances absorbed and available to reach the target tissues following drug administration
Drug actions (the actions just occur on a cellular level)
The cellular processes involved in the drug and cell interaction
Drug effect (chiva effect is OD or O/P/D)
The physiologic reaction of the body to the drug
Includes onset, peak, and duration of action
Onset (onset is therapeutic)
The time it takes for the drug to elicit a therapeutic response
Peak (the peak is the max)
The time it takes for a drug to reach its maximum
therapeutic response
Duration (duration is therapy)
The time a drug concentration is sufficient to elicit a
therapeutic response
therapeutic drug monitoring - Peak level
Highest blood level