Renal Flashcards
Afferent (arrive) arteriole caries blood
to the glomerulus
Efferent (exit) tubule caries blood
from the glomerulus
renal perfusion - what % of cardiac output?
20-25% of CO
volume of renal blood flow?
600 mL/min
a decrease in diastolic pressure is associated with
AKI, but decreased MAP isn’t.
kidney functions
fluid balance, BP control (renin), acid base (H and bicarbonate), electrolyte balance, removal of wast, erythorpoetin, vitamin D activation
angiotensin II - increases BP how? and what about heart and prosties?
vasoconstriction, increases myocardial contractility, prostaglandin release (lipids that control inflammation),
angiotensin II - increases volume how? And what about ADH?
aldosterone, Na and water reabsorption, K excretion, and ADH release
older adults and kidney function - blood flow? GFR?
Sclerosis of the glomerulus and renal vasculature
Decreased blood flow
Decreased GFR
Altered tubal function and acid–base balance
older adults and kidneys - drug
decreased clearance, increased interactions
older females
estrogen protects and slows progression of CKD
older males
androgen deprivation slows progression of CKD
specific gravity (the year 1000)
1.002 - 1.035
pH
4.5 - 8.0
BUN elevated with what? (steroid BUNS)
elevated with renal disease, steroids, dehydration, malnutrition
creatinine - men vs women
men slightly higher than women due to muscle.
creatinine elevated (creatins exercise and have low muscle mass)
Elevated with CKD, kidney obstruction, intense exercise, low muscle mass, pregnancy, certain meds (Bactrim), corticosteroids, Vitamin D
BUN/Cr ratio - increased (buns get bigger with no water)
FVD or hypoperfusion of kidneys
BUN/Cr ratio - decreased
FVE or malnutrition
GFR decreased by
one mL/min/year after age 40
abrupt decrease in GFR will show (africa down, cretins up)
increase in creatinine
gradual decrease in GFR and renal blood flow with aging will show
little change in GFR
is urea normal or abnormal?
normal constitute of urine
normal capacity of bladder
300 - 500 mL
palpate left kidney? (the left is left out)
rarely able to palpate
kidney injury - inspect for
Bleeding: bruising, abdominal distention, guarding, urinary meatus
kidney injury - JVD
Volume depletion or overload: JVD (first supine then @ 45-degree angle/semi-Fowlers)
kidney injury - albumin/weight
Edema: dependent, eyes, hands, cheeks, feet, over bony prominences,
pitting (scale of 1-4)
check weight, hypoalbuminemia
Auscultation for someone with kidney injury focuses on the
heart, lungs and blood pressure
Heart
rate, rhythm and extra heart sounds (S3 & S4 FVE) use bell; pericardial friction rub (3rd intercostal space to the left of sternum, lean forward)
Lungs
Crackles, new dyspnea upon mild exertion, orthopnea, PND (paroxysmal nocturnal dypnea)
Blood pressure
FVD either fluid or hemorrhage losses. Orthostatic hypotension
Kidneys examination
Patient side-lying or sitting, with examiner’s hand over the costovertebral angle; then striking the hand with the other fist which produces a normal dull thud.
fluid assessment
skin turgor, mucous membranes, I and O, edema or ascites, engorged neck or hand, crackles, dyspnea, tachycardia, hypo/hypertension, S3 and S4, HA, blurred vision, vertigo when rising, mental changes, serum osmolality
assessment of electrolyte and waste products
CBC, BUN, ECG, mental status, chvostek’s and trousseau, numbness, muscle strength, GI changes, itching
hydrostatic is always
water
itching can be
calcium
kidneys can’t compensate when systolic gets below
80 or 70
vitamin D
from sun, coverted to calcidiole in liver, calcidiole goes to kidneys where it’s converted to active form of vitamin D. Vitamin D is needed to absorb calcium in GI tract.
calcium has inverse relationship with
phosphate, so if calcium is low from renal failure, phosphate is high.
prostaglandins in kidneys (prostie is stingy)
cause vasodiation and increase blood flow to kidneys only
bradykinin also released by
kidneys, and just increases permiability to let certain solutes in
do kidneys get smaller when we age?
YES! they shrink
if specific gravity never changes throughout the day, it means that
the kidneys are damaged
for a UA, try to get the
first sample of the day and send it to the lab within an hour. if you can’t, it needs to be refrigerated.
if BUN is elevated and everything else is normal, it’s
dehydration (fluid volume deficit)