Reproductive Flashcards
DES babies
birth defects
estrogen - reasons to take
Atrophic vaginitis- thinning, drying & inflammation of
vaginal walls
Hypogonadism
🞑 Oral contraception (given with a progestin)
🞑 Dysmenorrhea
🞑 “Hot flashes” of menopause (vasomotor symptoms) 🞑
🞑 Breast & Prostate Cancer
🞑 Osteoporosis
estrogen contraindications
Any estrogen-dependent cancer
Undiagnosed abnormal vaginal bleeding
Pregnancy - can cause a miscarriage
Active thromboembolic
disorder or history of stroke,
venous blood clot
Thrombolytic events—most serious
estrogen adverse
Amenorrhea, breakthrough uterine bleeding
Tender breasts, fluid retention, headaches (increased fluid)
Premarin (Enjuvia®, Premarin®)
replace estrogen deficit
leg cramps
DVTs usually start in the back of the leg so ask about back of leg when sitting for long periods. will hurt when they cross their legs.
Progestins - produced by…
Produced by corpus luteum, then pregnant placenta
Synthetic derivatives of progesterone
Progestins: Indications
Treatment of functional uterine bleeding caused by: after birth
🞑 Hormonal imbalance, fibroids, or uterine cancer
Treatment of primary and secondary amenorrhea,
palliative cancer & endometriosis
Prevent conception
Progestins: Indications - palliative treatment
of some cancers and
endometriosis
Prevention of threatened miscarriage relaxing uterine smooth muscles
Alleviation of PMS symptoms
Progestogens : Indications - Megestrol (Megace) **
synthetic progestin
🞑 Adjunct therapy for treatment of breast and
endometrial cancers
****Management of anorexia, cachexia, or unexplained
weight loss in AIDSpatients
🞑 To stimulate appetite and promote weight gain in
cancer patients
🞑 Female infertility
Progestins: Adverse Effects
Liver dysfunction- cholestatic jaundice- (flow of bile from
liver slows/stops)
Thrombophlebitis, thromboembolic disorders,
such as PE
Nausea, vomiting
Amenorrhea, breakthrough uterine bleeding,
“spotting”
Edema, weight gain or loss & depression
Medroxy-progesterone***
Action: has effects similar to those of progesterone;
inhibits secretion of Pituitary Gonadotropins thus prevents
ovulation
Class: synthetic progestogens
Use: treat absent or irregular menstrual periods,
abnormal uterine bleeding. Also used to decrease
the risk of endometrial hyperplasia & renal cancer
How supplied: tablets, injections\
Dont give to anyone under 25 - leaches calcium out of bones
*****Depo-Provera = 1 shot coverage for 3 months, caution for
under 25 years of age due to bone density issues.
Medroxyprogesterone (Provera®) - Precautions: Nursing Considerations:
🞑 May causemelasma.Not for usein pregnancy
🞑 Teachwomento do BSE (breast self exam)
🞑 Teachwomen:take Provera by mouthwith or without food.
Takeat the sametime every day, with doses not more than
24 hours a part.
🞑 Teachwomen: If a dose ismissed,take it assoon as
possible. If it is almost time for the next dose, skip the
missed dose and go back to the regular dosing schedule.
Do not take 2 dosesat once
🞑 If miss 2 active pill in 3 weeks or miss 3 or more in a
row. Instruct pt to throw out rest of pack and Start a new
pack that day.
Contraceptive Drugs - contraindications
Oral medications
🞑 Monophasic, biphasic, and triphasic forms
Triphasic form most closely duplicates the normal hormonal
levels of the female cycle*
Depo- Provera- 3 month in 1 shot
🞑 Newer extended cycle products
🞑 Most contain estrogen-progestin combinations
plan B
Levon-orgestrel = Plan B, w/in 72 hrs of unprotected sex &
f/up dose 12 hrs after first dose. ($40-50.00)
Seasonale
( extended cycle), both estrogen & progestin,
women will only have 1 menstrual cycle every 3 months
Contraceptive Drugs:
Adverse Effects
Drawbacks to the use of these drugs include:
🞑 Hypertension
🞑 Thromboembolism, possible PE, MI, stroke
🞑 Alterations in lipid and carbohydrate metabolism
🞑 Increases in serum hormone concentrations
These effects are caused by the estrogen
component
contraceptive adverse
May alsocause:
🞑 Edema,dizziness, headache, Depression,
nausea, vomiting,diarrhea, increased
appetite, increased weight, breast &
changes, many others
contraceptive interactions***
penicillin and Cephalosporins
Contraceptive
Drugs: Interactions - Drugs that may have reduced
effectiveness
Anticonvulsants, beta-blockers, hypoglycemic drugs,
oral anticoagulants, theophylline, hypnotics,
tricyclic antidepressants
fertility drugs - Clomiphene (Clomid®, others)
Nonsteroidal ovulation stimulant
🞑 Blocks estrogen receptors in the uterus and brain,
resulting in a false signal of low estrogen levels - this will produce twins sometimes bc more than one egg
fertility - mentropins (Pergonal®)
Standardized mixture of FSH and LH
🞑 Stimulates development of ovarian follicles,
leading to ovulation
🞑 May also be given to
men t to stimulate
spermatogenesis
🞑 From urine of post
menopausal women
Chorionic gonadotropin alfa (Ovidrel®)
Recombinant form of human chorionic gonadotropin
🞑 Causesrupture and ovulation of mature ovarian
follicles, and maintenance of corpus luteum
Fertility Drugs: Indications
Used primarily to induce ovulation in anovulatory
patients