Pharm chap 4 - 7 Flashcards
legend drug
another name for a prescription drug
pharmacogenomics
how certain genetic traits affect drug response
cytochrome P-450
varies among ethnicities, can affect plasma levels and intestensities of drugs.
lower lithium for
african americans, japanes and tiawanese
a product label can read “for depression” but not…
known to cure depression
expedited drug approval known as
fast track - AIDS drugs - can be dangerous
phase 1 studies
small number of healthy subjects to determine optimal dose range and the pharmocokinetics of drug. and if further testing is needed
phase 2 studie
volunteers who have the disease to determine drug’s effectiveness and adverse effects. theraputic dosage range refined.
phase 3 studies
large number of patients - study rare adverse effects. may use placebo or double-blind.
phase 4 studies
postmarketing, voluntary to obtain further proof. info gathered for 2 years after drug release. FDA may issue black box warning during this phase.
class I recall of drug
most serious. reasonable probability of serious effect or even death
class II recall drug
may result in temporary adverse effects, but long lasting is rare.
class III recall drug
use of drug not likely to cause any significant health problems
Tachyphylaxis refers to a quickly developing tolerance that occurs after repeated
administration of a drug. (NTG in chest pain)
Cumulative
Tachyphylaxis refers to a quickly developing tolerance that occurs after repeated
administration of a drug. (NTG in chest pain)
Cumulative
