Pharm Final 4 Flashcards
Phenylephrine, blood vessels
constrict (sympathomimetic a agonist)
used in cold and allergy products
Phenylephrine (sympathomimetic a agonist)
If given parenterally, used to treat shock-like stages
Phenylephrine
prolong anesthesia and maintain blood pressure during spinal anesthesia
Phenylephrine
used for open angle glaucoma
Phenylephrine
Side effects: fear anxiety restlessness headache nausea decreased urine formation
Phenylephrine (sympathomimetic a agonist)
contraindications for Phenylephrine severe ___ and __ ___ __
hypertension and narrow angle formation (sympathomimetic a agonist)
Phenylephrine contraindication
severe hypertension and narrow angle formation (sympathomimetic a agonist)
Phenylephrine interaction with MAO inhibitors
severe hypertension (sympathomimetic a agonist)
Phenylephrine interaction with tri-cyclic antidepressants
enhanced sympathomimetic effects (sympathomimetic a agonist)
albuterol effect on lungs
bronchodilation (sympathomimetic b agonist)
albuterol (sympathomimetic b agonist) used for 2 health problems
asthma and COPD
side effects: tremor dizzy excited/insomnia tachycardia
albuterol (sympathomimetic b agonist)
albuterol (sympathomimetic b agonist) contraindication:
_ _ disorder
d___
hyper___
CV disorder
diabetes
hyperthyroidism
2 drug interactions for albuterol (sympathomimetic b agonist)
MAO inhibitors
Tri-cyclic antidepressants
Prazosin effect on blood pressure
decrease (sympathetic a blocker)
Prazosin is used to decrease BP in
pheochromocytoma
used to reverse vasoconstriction actions of NE and DA
Prazosin (sympathetic a blocker)
used to treat benign prostatic hyperplasia
prazosin
Side effects: orthostatic hypotension miosis (constriction of pupils) tachycardia nasal congestion confusion, headache, dry mouth, can't ejaculate
prazosin
Tell clients to avoid over the counter preparations
prazosin
prazosin interactions
sympathomimetics, diuretics
Nursing implications:
monitor BP and pulse
caution pt to make position changes slowly (orthostatic hypotension)
encourage pt with additional interventions for hypertension
prazosin (sympathetic a blocker)
propranolol effect on HR
decrease (sympathetic b blocker)
propranolol effect on cardiac output and contractility
decrease (sympathetic b blocker)
propranolol effect on renin release
decrease (sympathetic b blocker)
uses:
antiarrhythmic (especially atrial tachyarrhythmias)
antiginal
hypertension
decrease mortality in pts who already have had an MI
migraine
glaucoma
propranolol (sympathetic b blocker)
toxicity: bradycardia AV block respiratory distress cardiac failure prolong insulin-induced hypoglycemia
propranolol
drug interactions: oral hypoglycemias calcium channel blockers MAO inhibitors sympathomimetics
propranolol
Must be withdrawn slowly to avoid withdraw symptoms
propranolol (and other sympathetic b blocker)
nursing implications:
monitor BP
warn pt about orthostatic hypotension
avoid alcohol
propranolol (and other sympathetic b blocker)
ergotamine can be used to treat ___ by constricting blood vessels during the 2nd phase of the attack
migraine
side effects:
vasospasm, cold extremities, hypo and hypertension, tachycardia or bradycardia
ergotamine
used in combination with an anticholinergic and barbituate in the treatment of GI disorders such as GERD and ulcers (Bellergal)
ergotamine
ergotamine nursing implication, caution pt that drug may cause __ and __
drowsiness and dizziness
ergotamine nursing implication, encourage pt to avoid ___ as it may worsen the headache
alcohol
indirect acting parasympathomimetic drugs work by inhibiting
acetylcholinesterase
indirect acting parasympathomimetic drugs are divided among
those that cross the BBB and those that can’t
bethanechol effect, glandular secretion (saliva, gastric acid)
increase (parasympathomimetic)
bethanechol effect, lungs
bronchoconstriction (parasympathomimetic)
bethanechol effect, pupils
constrict (parasympathomimetic)
bethanechol effect, aqueous humor
drains it (parasympathomimetic)
bethanechol effect, GI
increase (parasympathomimetic)
bethanechol effect, voiding
increase (parasympathomimetic)
bethanechol effect, hr
decrease (parasympathomimetic)
tacrine effect, glandular secretion (saliva, gastric acid)
increase (indirect BBB parasympathomimetic)
tacrine effect, lungs
bronchoconstrict (indirect BBB parasympathomimetic)
tacrine effect, pupils
constrict (indirect BBB parasympathomimetic)
tacrine effect, aqeous humor
increase outflow (indirect BBB parasympathomimetic)
tacrine effect, GI
increase (indirect BBB parasympathomimetic)
tacrine effect, voiding
increase (indirect BBB parasympathomimetic)
tacrine effect, HR
decrease (indirect BBB parasympathomimetic)
pyridostigmine effect, glandular secretion (saliva, gastric acid)
increase (indirect no BBB parasympathomimetic)
pyridostigmine effect, lungs
bronchoconstrict (indirect no BBB parasympathomimetic)
pyridostigmine effect, pupils
constrict (indirect no BBB parasympathomimetic)
pyridostigmine effect, aqueous humor
increase outflow (indirect no BBB parasympathomimetic)
pyridostigmine effect, GI
increase (indirect no BBB parasympathomimetic)
pyridostigmine effect, voiding
increase (indirect no BBB parasympathomimetic)
pyridostigmine effect, HR
decrease (indirect no BBB parasympathomimetic)
used post operatively to stimulate the effects of the GI and GU
parasympathomimetic
used to reverse the effects of neuromuscular blocking agents
parasympathomimetic
parasympathomimetic can be used for g____
glaucoma
indirect acting cholinomimetics that don’t cross the BBB are used in combination with atropine to treat ___ gravis
myasthenia gravis
indirect parasympathomimetic that do cross the BBB can be used to treat
alzheimers
contraindications: asthma peptic ulcers UTI pregnancy bradycardia
parasympathomimetic
nursing implications:
monitor pulse and respiration regularly
assess neuromuscular status
monitor for symptoms of overdosage (muscle weakness, dyspnea)
give atropine if overdosage has occurred
monitor urinary output
parasympathomimetic
cholinergic blockers are aka ___ blockers
parasympathetic blockers
the 3 parasympathetic blockers with need to know are ___ alkaloids
Belladonna Alkaloids
atropine, ipratropium bromide, oxybutyrin effect, pupil
dilation (parasympathetic blockers )
atropine, ipratropium bromide, oxybutyrin effect, secretions of the mouth and sweat glands and bronchi
decrease (parasympathetic blockers )
atropine, ipratropium bromide, oxybutyrin effect, lungs
bronchodilation (parasympathetic blockers )
atropine, ipratropium bromide, oxybutyrin effect, HR
increase (parasympathetic blockers )
atropine, ipratropium bromide, oxybutyrin effect, BP
none (parasympathetic blockers )
atropine, ipratropium bromide, oxybutyrin effect, GI
decrease (parasympathetic blockers )
parasympathetic blockers work by blocking the _ receptors
m receptors
given prior to surgery because it slows GI secretion
atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers )
used for parkinson’s
atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers )
treats paralysis during mushroom poisoning
atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers )
treating IBS
atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers )
side effects:
photophobia, blurred vision, papillary dilation, increased intraocular pressure
weak, dizzy, insomnia
dry mouth, constipation, urinary retention
atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers and anticholinergic)
classic side effects of atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers and anticholinergic)
dry mouth, constipation, urinary retention
routes of administration for atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers and anticholinergic)
transdermal, SQ, oral, eye
contraindications:
glaucoma
GI obstruction
benign prostatic hyperplasia
atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers and anticholinergic)
nursing implications:
monitor vitals
watch for urinary retention and constipation
warn pt that they may have blurry vision/drowsy
atropine, ipratropium bromide, oxybutyrin (parasympathetic blockers and anticholinergic)