HESI Cardiovascular system Part 1 Flashcards
Blood consists of cells and cell fragments, in this context known as ____ ____
Blood also has water with dissolved molecules are ____ ____
formed elements
blood plasma
fancy word for RBC
erythrocyte
main function of RBC is to transport
O2 and CO2
The protein in RBCs is called
hemoglobin
O2 and CO2 attach to the ____ of the rbc
hemoglobin
Mature RBCs maximize their cargo space by not having
nucleus and other organelles
____ forms when CO2 attaches to AAs of the globin part of the hemoglobin molecule.
Carbaminohemoglobin
an enzyme in erythrocytes, it converts CO2 and H2O in the cells to H and HCO3
Carbonic anhydrase
Most of the CO2 collected from tissues travels in the ____ in the form of ____
A smaller amount of CO2 stays in the ____ and is transported as ____ ____
RBCS
HCO3
plasma
bicarbonate ion
RBCs have a short life. the degenerated ones are broken down in the ____ and ____
liver and spleen
the kind of cell that breaks down RBCs in the liver and spleen is ____ ____ ____ cells (____)
phagocytic white blood cells
macrophages
process of breaking down RBCs, the ____ and ____ parts of hemoglobin are separated. ____ is reduced to AAs
globin and heme
globin
process of breaking down RBCs, ____ is removed from the heme group and is bound to protein for storage
iron
process of breaking down RBCs, the remainder of the heme group is broken down into ____ (a yellow-orange pigment)
bilirubin
Liver cells add bilirubin to bile, which enters the small intestine during the digestion of fats. Bilirubin is then converted into ____ by intestinal bacteria
urobilinogen
There are 2 main groups of leukocytes ____ and ____ (one has granules in the cytoplasm and the other doesn’t)
granulocytes
agranulocytes
the most numerous of the granulocytes
neutrophils
granulocyte that increases in number during parasitic infection or allergic reaction
eosinophils
granulocyte that releases histamine
basophil
The 3 types of granulocytes are
NEB
neutrophils
Eoisonphils
Basophils
the first kind of granulocyte to arrive at an infection
neutrophils
neutrophils respond to chemicals release by damaged cells, the chemicals are called ____. Neutrophils engulf bacteria by ____.
chemotaxis
phagocytosis
kind of granulocyte that is similar to mast cells in connective tissue
basophil
an agranulocyte, classified as small, med, large
lymphocyte
an agranulocyte that goes into tissue and becomes a macrophage
monocyte
the only leukocytes that return to the bloodstream
lymphocytes
The 2 groups of lymphocytes
T cells and B cells
the 2 kinds of agranulocytes
monocytes
lymphocytes
the kind of lymphocyte that attacks aberrant cells
T cells
the kind of lymphocyte that toxins, viruses etc
B cells
fragments of big cells called megakaryocytes
platelets (thrombocytes)
another word for platelets
thrombocytes
platelets’ job is to adhere to
damaged blood vessel walls
the liquid material remaining after blood-clotting proteins have been removed from plasma as a result of clotting
serum
another word for blood formation
hemopoiesis
hemopoiesis takes place in the ____ bone marrow
red
hemopoietic stem cells are called
hemocytoblasts
erythropoiesis, the process of making erythrocytes, beings with the formation of ____ from the hemopoietic stem cells
proerythroblasts
young erythrocytes are called
reticulocytes
a hormone produced mostly by the kidneys, stimulates bone marrow to make new erythrocytes
eythropoietin
a condition where not enough oxygen is delivered to body cells is called
hypoxia
another word for stoppage of bleeding
hemostasis
hemostasis, first step is
vasoconstriction
hemostasis, second step, ____ fill the hole
platelets (platelet plug)
hemostasis, the last step is
coagulation
a complex series of reactions that make liquid blood into a gel
coagulation
coagulation has 3 major steps. 1, The formation of factor ____ and ____
factor X and prothrombinase
coagulation, 2, prothrombin is converted to ____
thrombin
coagulation, 3, fibrinogen is converted to ____
fibrin
in coagulation, ____ forms long strands that bind platelets together, thus forming a clot
fibrin
the breakdown of the clot is
fibrinolysis
If RBCs are transfused to another patients but are rejected, its because antibodies bind them together which is called ____ (clumping) which leads to destroying them
agglutination
Different blood groups (aka blood types) are called
agglutinogens
blood leaving the heart goes to ____ then ____ then ____. Then it returns to ____ and then ____
arteries arterioles capillaries venules veins
In pulmonary circulation, ____ blood travels from the ____ side of the heart to the lungs
deoxygenated blood
right
deoxygenated blood returns to the ____ side of heart
right side
The pointed end of the heart is called the
apex
The heart is surrounded by the pericardium, which has 2 layers:
outer fibrous pericardium
inner serous pericardium
Between the 2 layers of the serous pericardium is _____ fluid
serous
The walls of the heart consist of 3 layers:
endocardium
myocardium
epicardium
The visceral layer of the serous pericardium is called the
epicardium
The muscular layer of the heart
myocardium
the myocardium consists of contracting cardiac muscles and noncontracting ____ fibers
Purkinje fibers
Purkinje fibers function
conduct nerve impulses
a serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart.
epicardium
Cardiac cells (cardiomyocytes) are in this layer
myocardium
layer that is continuos with blood vessels
endocardium
the number of valves in the heart
4
The 2 upper chambers, the right and left atria, are separated by the ____ ____
interatrial septum
The pumping machines of the heart are the 2
ventricles
The ventricles are separated by the ____ ____
interventricular septum
prominent groove on the surface of the heart, marks the junction of atria and ventricles
coronary sulcus
Function of the right atrium
temporary storage (so blood is ready and waiting for the right ventricle)
deoxygenated blood from the systemic circulation enters the right atrium through 3 veins:
superior vena cava
inferior vena cava
coronary sinus
The right AV valve is also called the
tricuspid
The pumping chamber for the pulmonary circuit is the ____ ____
right ventricle
valve blood goes through to get to the lungs
pulmonary semilunar valve
first part of the large artery leading toward the lungs
polmonary trunk
When the right ventricle contracts, the ____ ____ closes
right AV (tricuspid)
Small tendon like cords, the ____ ____ are attached to the ____ muscles at the bottom on the ventricle
chordae tendineae
papillary muscles
the chordae tendineae limit the extend to which the
AV valve can be closed (so that it doesn’t overshoot all the way into the atrium
The left atrium receives ____ blood
oxygenated
The left AV valve is also called the
bicuspid
Most of the valves in the heart have how many cusps
3
The ventricle is the pumping chamber for the ____ circulation
systemic circulation
The strongest chamber is the
left ventricle (to pump blood to the whole body)
When the left ventricle contracts, it pumps blood through the ____ ____ ____
aortic semilunar valve
big artery leaving the heart and leads to the rest of the body
aorta
When the left ventricle contracts, the ____ ____ ____ closes
left AV valve (bicuspid)
The fetal heart has 2 extra pathways
the foramen ____
the ductus ____
foramen ovale
ductus arteriosus
in a fetus The foramen ovale is an opening across the ____ ____
interarterial septum
The ____ circulation consists of blood vessels that service the heart itself
coronary circulation
The 2 arteries that come from the aorta and service the heart are the
left coronary artery
right coronary artery
The left coronary artery has 2 branches-
the anterior ____ artery
and
the ____ artery
anterior interventricular artery
circumflex artery
The right coronary artery has 2 branches-
the posterior ____ artery
and
the ____ artery
posterior interventricular artery
marginal artery
blood from the coronary circulation returns to the right ____ by way of an enlarged blood vessel, the ____ ____
coronary sinus
3 veins feed the coronary sinus
the great ____ ____
the middle ____ ____
the ____ ____ ____
great cardiac vein
middle cardiac vein
small cardiac vein
Mitral Valve separates what from what
left atr from left vent