344 Test 2 Study Guide Topics Flashcards
Increase in ADH ___ urine output
decreases
Decrease in ADH increases __ output
urine
Normal Sodium levels
135 to 145 mEq/L
Sodium attracts
water
Special cells in the kidneys monitor for __ levels
sodium
If the kidneys detect a decrease in sodium levels, __ is released which (indirectly) causes blood pressure to rise
renin
When you have too much sodium (hypernatremia) your kidneys cannot excrete the excess sodium and also retain water at the same time. This increased fluid volume raises
blood pressure
Sodium is also used to determine the concentration of
urine
Potassium is mostly ___ the cell membrane during rest
inside
when the cell is stimulated, potassium
flows out
An increase in K+ (hyperkalemia) causes the resting membrane potential to become more
positive
An increase in K+ (hyperkalemia) causes the resting membrane potential to become more positive moving it closer to the
threshold
plays key roles in cell signaling
calcium
plays key roles in muscle contraction
calcium
plays key roles in blood clotting
calcium
Normal calcium level is
8.5 to 10.5 mg/dL
Calcium affects __ ___ and automaticity via calcium channels
cardiac contractility
a special process in cardiac muscle where calcium ions diffuse in, making the cell more positive (depolarizing toward threshold)
Calcium leak
As part of the normal contraction cycle, heart cells have a special phase called
plateau
Cardiac cell remains above __ potential during plateau (remains active).
threshold
The plateau phase happens because ___ ___ continue allowing calcium ions to leak in, keeping the membrane positive.
calcium channels
The heart cell contraction ends when the calcium channels ___; this ends the plateau and the cell repolarizes
close
Calcium channel blockers are used as ___ drugs
antihypertensive
drugs that relax and widen blood vessels by affecting the muscle cells in the arterial walls.
Calcium channel blockers
are particularly effective against large vessel stiffness, one of the common causes of elevated systolic blood pressure in elderly patients
Calcium channel blockers
also frequently used to alter heart rate, to prevent cerebral vasospasm, and to reduce chest pain caused by angina
Calcium channel blockers
CCBs can directly influence the synthesis of ___ in adrenocortical cells, with consequent impact on the clinical treatment of hypertension
aldosterone
Calcium and ___ have an inverse relationship
Phosphate
An important cause of hypocalcemia is __ failure
renal
Only ___ calcium is able to participate in body functions
ionized
Hypercalcemia or Hypocalcemia, hypertension
Hypercalcemia
Hypercalcemia or Hypocalcemia, inhibits nerve activity
Hypercalcemia
Hypercalcemia or Hypocalcemia, Muscle weakness
Hypercalcemia
Hypercalcemia or Hypocalcemia, Increased thirst, urinating, kidney problems
Hypercalcemia
Hypercalcemia or Hypocalcemia, causes hypotension, cardiac insufficiency, arrhythmia.
Hypocalcemia
Hypercalcemia or Hypocalcemia, cause tetany, hyperactive reflexes, spasm
Hypocalcemia
Normal sys
Normal dias
Prehypertension sys
120-139
Prehypertension dias
80-89
Stage 1 hypertension sys
140-159
Stage 1 hypertension dias
90 to 99
Stage 2 hypertension sys
> 160
Stage 2 hypertension dias
> 100
Among young men and women, hypertension is more common in
men
With age, hypertension
increases
Kind of hypertension where the cause is unknown
primary hypertension
Kind of hypertension where the cause is related to a specific illness
secondary hypertension
Between primary and secondary, the most common hypertension is
primary
A single BP reading is not enough to diagnose
hypertension
Elevated pressure during systole can lead to heart failure on the ___ side
left
Family history, race, and age are ___ risk factors in hypertension
Constitutional risk factors (part of primary hypertension)
primary hypertension is aka
essential hypertension
An infant’s BP is much ____ than an adult’s
lower
diastolic pressure begins to decline when someone turns 50; systolic pressure
continues to rise
another factor contributing to development of hypertension is ___ resistance
insulin
Raises BP acutely, but not chronically
stress (therefore it’s not really a risk factor)
Reduction of salt, sodium, alcohol can reduce risk for
hypertension
Abdominal fat verse buttock/leg fat: which is more of a risk for hypertension
Abdominal
Oral ___ agents can cause hypertension
contraceptive
street drugs, sympathomimetics, erythropoietin, licorice, sleep apnea can be risk factors for
secondary hypertension
the goal of treating hypertension is to reduce BP below
140/90
The goal of treating hypertension for diabetic patients is to reduce BP to
less than 130/80
Hypertension causes __ ventricular hypertrophy
left
Can also cause peripheral vascular disease, retinopathy, and chronic kidney disease
Hypertension
happens when the veins can’t function properly for example, the valves wear out or skeletal muscle pumps are impaired
Venous HTN
The build-up of fats, cholesterol, and other substances in and on the artery walls
Atherosclerosis heart disease
Atherosclerosis involves __ cell injury
Endothelial
Atherosclerosis involves Migration of ___ cells
inflammatory
Atherosclerosis involves __ muscle proliferation and lipid deposition
Smooth
Atherosclerosis involves Gradual development of the atheromatous ___
plaque
a procedure where fluid is aspirated from the pericardium (the sac enveloping the heart)
Pericardiocentesis
chest pain caused by reduced blood flow to the heart muscle
Angina
angina symptom of ___ artery disease, it can be acute or chronic
coronary
angina can be relieved by rest or
nitroglycerine
__ angina occurs with activity, cold weather, or stress
stable
___ angina occurs at rest
unstable
___ angina is caused by coronary artery spasm
variant (aka vasospastic)
unstable angina, or angina that is new ___/___ intensity means you could be at serious risk for heart attack
new onset/increasing
stable angina and variant angina are caused by
chronic ischemic heart disease
unstable angina is caused by
acute coronary syndrome
Signs and Symptoms, Hypotension (LOW BP) and Shock
Acute MI
Signs and Symptoms, Weakness in arms and legs
Acute MI
Signs and symptoms of __ __
Nausea, Vomiting
Tachycardia (high HR) Vasoconstriction
Anxiety, feeling of impeding doom
Acute MI
ventricular wall is weak and swells into a blood bubble
Ventricular Aneurysms
complication of acute MI can include __ failure
heart failure
complication of acute MI can include ___ (inflammation of the Heart)
Pericarditis
complication of acute MI can include ___ ___ (not enough blood for heart to pump)
Cardiogenic Shock
complication of acute MI can include ___ (blood clot obstruction)
Thromboembolism
complication of acute MI can include ___ aneurysm
ventricular aneurysm
cardiac muscle disease is aka
Cardiomyopathy
In hypertrophic cardiomyopathy, there’s a thickening of the __ septum and the left ___
ventricular septum and left ventricle
hypertrophic cardiomyopathy can be used by mutation in
genes
hypertrophic cardiomyopathy is treated with
beta blockers
hypertrophic cardiomyopathy is the most common cause of death in
young athletes
Rare disease in which the ventricle walls are __ but not necessarily thicker
rigid
symptoms- dyspnea, peripheral edema, fatigue, weakness
restrictive cardiomyopathy
a condition in which the heart’s ability to pump blood is decreased because the heart’s main pumping chamber, the left ventricle, is enlarged and weakened
Dilated Cardiomyopathy