VASCULITIS HISTO

Question 1

AKA vasculitides: non infectious systemic necrotizing inflammation of any vessel

Answer 1

vasculitis

Question 2

vasculitis characterized how?

Answer 2

inflammation and necrosis

Question 3

what are the common pathogenic mechanisms?

Answer 3

immune complex formation

ANCA

Question 4

vasculitis types, 8 of them?

Answer 4

polyarteritis nodosa
wegener's granulomatosis
microscopic polyarteritis
giant cell arteritis 
takayasu's arteritis 
kawasaki's disease
thromboangitis obliterans
raynauds disease/phenomenon

Question 5

name this type of vasculitis based on histologic features?

transmural inflammation

systemic involvement

small to medium sized muscular arteries

lesions of varying ages
thrombosis

sharply segmental
thrombosis

Answer 5

polyarteritis nodosa

Question 6

name this type of vasculitis based on histologic features?

necrotizing granulomas of upper and/or lower respiratory tract

granulomatous vasculitis of small arteries and veins

crescentic, glomerulonephritis

Answer 6

wegener’s granulomatosis

Question 7

name this type of vasculitis based on histologic features?

palpable purpura

P-ANCA

hemoptysis, hematuria and proteinuria

bowel pain and bleeding

muscle pain and weakness

Answer 7

microscopic polyarteriitis

Question 8

name this type of vasculitis based on histologic features?

decrease lumen size
granulomatous inflammation
non specific WBC infiltration through arterial wall
thrombus formation
lumen obliteration

Answer 8

giant cell arteritis

Question 9

name this type of vasculitis based on histologic features?

early: granulomatous inflammation
late: collagen fibrosis with inflammation

Answer 9

takayasu’s arteritis

Question 10

name this type of vasculitis based on histologic features?

coronary artery vasculitis leading to aneurysm formation and superimposed thrombosis

Answer 10

kawasaki’s disease

Question 11

name this type of vasculitis based on histologic features?

sharply segmental acute and chronic vasculitis of medium and small arteries

polymorphonuclear infiltrate of all layers

mural or occlusive thrombus

Answer 11

thromoangiitis obliteration