STEPS TO ACUTE INFLAMMATION HEALING

Question 1

what are the cellular events in inflammatory healing?

Answer 1

margination 
adherence
transmigration
chemotaxis and leukocyte activation
phagocytosis

Question 2

name this cellular event?

leukocytes are swept against the vascular wall in post capillary venues due to flow dynamics and roll along the vessel wall
-selectins (an adhesion molecules) are responsible

Answer 2

margination and rolling

Question 3

what protein is this?

four molecular families especially selectins that mediate rolling, contain an extracellular domain that binds sugars and expressed on endothelial cells in low levels or not at all

Answer 3

adhesion molecules

Question 4

name this cellular event?

determined by binding of complementary adhesion molecules, integrins, located on the WBC

expression and attractiveness of the molecule influenced by chemical mediators (chemokines)

uses integrins

Answer 4

adhesion

Question 5

name this cellular event?

migration of WBC through vessel wall

squeeze between cells at intercellular junctions
-mediated by PECAM-1

Answer 5

transmigration

Question 6

what are the sites of adhesion molecules?

Answer 6

endothelial cell
leukocyte
platelets

Question 7

name this cellular event?

locomotion along a chemical gradient in which granulocytes, monocytes, and lymphocytes respond

can be endogenous and exogenous

Answer 7

chemotaxis

Question 8

what are the chemotactic agent functions?

Answer 8

locomotion

leukocyte activation

Question 9

leukocyte activation causes?

*stimuli?

Answer 9

production of arachidonic acid metabolites

degranulation, secretion of lysosomal enzymes, and oxygen burst

modulation of leukocyte adhesion molecules

*microbes, products of necrotic cells, mediators