COMPONENTS OF HEMOSTASIS TERMS

Question 1

both prothrombotic and antithrombotic

Answer 1

Endothelial Cells

Question 2

vasodilates and inhibits platelet aggregation

Answer 2

Nitric oxide

Question 3

inhibits platelet aggregation

Answer 3

Prostacyclin I2

Question 4

degrades ADP and inhibits platelet aggregation

Answer 4

Produce Adenosine Diphosphate

Question 5

indirectly binds to thrombin, converting it to an anticoagulant capable of activating protein C

Answer 5

Thrombomodulin

Question 6

requires protein S

Answer 6

Tissue Factor Pathway Inhibitor (TFPI)

Question 7

endothelial cells produce mediators that insulates platelets and coagulation proteins from thrombogenic subendothelial ECM

Answer 7

Antiplatelet effects

Question 8

Shields coagulation factors from tissue factor in the vessel wall and produces membrane-associated heparin-like molecules

Answer 8

Anticoagulant effect

Question 9

cell fragments derived from megakaryocytes

Answer 9

Platelets

Question 10

include Fibrinogen, Fibronectin, factors V & VII, PF4, PDGF, TGF-β, vWF

Answer 10

α granules

Question 11

include ADP/ATP, ionized Ca, histamine/serotonin, epinephrine

Answer 11

Electron-dense bodies

Question 12

attachment to sites of endothelial injury

Answer 12

Adhesion

Question 13

adhesions lead to irreversible shape change and the release of granules

Answer 13

Activation

Question 14

platelet to platelet adherence

Answer 14

aggregation

Question 15

coverts soluble proenzymes into activated enzymes culminating
in the production of thrombin, which converts soluble fibrinogen into insoluble fibrin

Answer 15

coagulation cascade

Question 16

fat soluble cofactor for liver microsomal carboxylase

Answer 16

Vitamin K