DISORDERS OF FIBRINOLYSIS

Question 1

acute, subacute or chronic thrombohemorrhagic
disorder characterized by activation of the coagulation cascade

shock is often common denominator

Answer 1

Disseminated Intravascular Coagulation (DIC)

Question 2

system wide formation of?

Answer 2

microthrombi throughout circulation

Question 3

Leads to consumption of?

Answer 3

platelets, fibrin, coagulation factors (patient at bleeding risk)

Question 4

Causes secondary activation of?

Answer 4

fibrinolytic system

Question 5

Labs for DIC?

Answer 5

▪ Thrombocytopenia (“chewing up their platelets”)
▪ Hyperfibrinogenemia (“using up their fibrinogen”)
▪ Prolonged PT, aPTT, TT (fibrinogen completely used up)
▪ Elevated Fibrin degraded products (fibrin split products)
-D-dimer***