BIOLOGY OF GROWTH STEPS Flashcards
1
Q
what are the 4 steps involved in the biology of growth?
A
neoplastic transformation of the cell
growth of the transformed cell
local invasion
distant metastasis
2
Q
what are the factors influencing tumor growth?
A
kinetics of tumor growth
tumor angiogenesis
tumor progression and heterogenity
number of cells in replicative pool
3
Q
this is the change of some cells within tumor to angiogenic phenotype; molecular basis of switch involves increased production of angiogenic inducers and/or loss of inhibitors
A
angiogenic switch
4
Q
proteases release what angiogenic inducers/inhibitors?
A
FGFb
angiostatin
endostatin
vaculostatin
5
Q
angiogenesis inducer?
A
VEGF
6
Q
angiogenesis inhibitor? via what gene?
A
TSP-1
P53
7
Q
what are the steps in local invasion?
A
detachment
attachment
degradation
migration
