ANEMIA OF CHRONIC DISEASE

Question 1

occur in what various chronic illnesses?

Answer 1

infection
malignancy
chronic inflammation
autoimmune disease

Question 2

what is the result of abnormal iron distribution?

Answer 2

iron release form storage macrophages inhibited by cytokines (they have enough iron; it just isn’t being released from stores)

Question 3

what lab values are decreased, increased?

Answer 3

decreased:
serum iron
transferrin saturation
TIBC

increased:
serum ferritin
bone marrow iron

Question 4

difference between anemia due to iron deficiency and chronic disease?

Answer 4

both decreased
serum iron
transferrin saturation

difference
iron, opposite for chronic disease
TIBC increased
Ferritin decreased
bone marrow storage