CYTOKINES IN INFLAMMATION Flashcards
cytokines in acute inflammation?
TNF
IL-1
IL-6
chemokines
cytokines in chronic inflammation?
IL-12
IFN-gamma
IL-17
stimulates expression of endothelial adhesion molecules and secretion of other cytokines, systemic effects
TNF
similar to TNF; greater role in fever
IL-1
systemic effects (acute phase response)
IL-6
recruitment of leukocytes to sites of inflammation; migration of cells to normal tissues
chemokines
increased production of IFN gamma
IL-12
activation of macrophages increased ability to kill microbes and tumor cells
IFN-gamma
recruitment of neutrophils and monocytes
IL-17
important cytokine produced by macrophages?
IL-1 and TNF
what are the chemokines produced?
CXC chemokines
-neutrophils
CC chemokines
-monocytes and macrophages
what releases ROS via what process?
neutrophils and macrophages synthesized via NADPH oxidase pathway
this is a vasodilator, inhibits platelet aggregation and antimicrobial?
nitric oxide
function of lysosomal enzymes of WBCs?
destroy phagocytized substances
this initiates inflammatory responses like secreting substance P?
also:
transmits pain
regulates vessel tone
modulates vascular permeability
neuropeptides
