DEFECTS IN LEUKOCYTE FUNCTION Flashcards
1
Q
what are the acquired diseases?
A
bone marrow suppression: tumors, radiation, chemotherapy
diabetes, malignancy, sepsis, chronic dialysis, anemia, malnutrition
2
Q
what are the genetic diseases?
A
LAD-1,2
chronic granulomatous disease
myeloperoxidase deficiency
3
Q
name the defect with this disease?
chronic granulomatous disease
A
decreased oxidative burst (phagocytic oxidase)
- membrane bound (x-linked)
- cyetoplasmic (autosomal recessive)
4
Q
name the defect with this disease?
myeloperoxidase deficiency
A
decreased microbial killing due to defective MPO-H2O2 system