COMPONENTS OF HEMOSTASIS

Question 1

components of cells

Answer 1

endothelial cells
platelets
coagulation cascade

Question 2

properties of endothelial cells?

Answer 2

antithrombotic properties

prothrombotic properties

Question 3

important antithrombotic properties?

Answer 3

antiplatelet effect
anticoagulant effect
fibrinolytic effect

Question 4

important prothrombotic properties?

Answer 4

• von Willebrand’s factor
• tissue factor
• binding sites of factors IX and X
• inhibitor to t-PA

Question 5

what are the anti platelet effects?

Answer 5

nitric oxide
prostacyclin 12
produces adenosine phosphate

Question 6

what are the anticoagulant effects?

Answer 6

thrombomodulin

tissue factor pathway inhibitor

Question 7

what is the fibrinolytic effect?

Answer 7

t-PA

Question 8

platelets contain 2 types of granules?

Answer 8

alpha granules

electron dense bodies

Question 9

function of platelets

Answer 9

adhesion
activation
aggregation

Question 10

why is adhesion important?

Answer 10

Requires vWF to serve as a molecular bridge between platelets and collagen

Question 11

important varibles of aggregation?

Answer 11

fibrinogen

ADP and thromboxane A2

Question 12

the coagulation cascade converts?

Answer 12

soluble fibrinogen into insoluble fibrin

Question 13

what are the three systems of the coagulation cascade?

Answer 13

intrinsic (hagemen)
extrinsic (tissue injury)
common pathway (factor X)

Question 14

the coagulation cascade uses this important vitamin?

produces what clotting factors

inhibited by?

Answer 14

vitamin K

2,7,9,10

coumadin, blocks factor 7 activity