TEST I HIGH YIELD Flashcards
cellular response to injury is based on?
type
duration
severity
consequences of cell injury depends on?
type
state
adaptibility
vulnerability of systems based on?
cell membrane
aerobic respiraton
protein synthesis
genetic apparatus
mechanisms of cell injury?
ATP depletion mitochondrial damage influx of calcium accumulation of oxygen defects in membrane permeability damage to DNA
ROS is produced by?
endogenous redox reactions
phagocytic production
nitric oxide
what are the intracellular accumulations?
abnormal metabolism
protein mutation
lack of enzyme
ingestion of indigestible materials
necrosis is based on?
ischemia
free radicals
nuclear damage
types of necrosis
2 pathways that activate caspases?
mitochondrial pathway
death receptor pathway
what are the signs of swelling?
rubor
tumor
dolar
calor
definitions of inflammation?
edema
exudate
purulent exudate
transudate
steps to getting WBCs outside blood vessel?
margination/rolling
adherence
transmigration
chemotaxis
outcomes of acute inflammation?
resolution
abscess
scar formation
chronic inflammation
main products of arachidonic acid metabolites?
cyclooxygenases
lipoxygenases
platelet activating factor
cytokines
cytokines involved in acute inflammation?
TNF
IL-1
IL-6
chemokines
cytokines involved in chronic inflammation?
IL-12
IFN-gamma
IL-17