PLASMA PROTEASES

Question 1

plasma proteases consists of?

Answer 1

complement
kinin
clotting systems

Question 2

what are the three independent pathways?

all pathways converge on this protein?

Answer 2

classical
alternate
lectin

C3 to C3b and C3a

Question 3

name this pathway?

activated by IgG/IgM (memory cells, 2nd line of defense

Answer 3

classical pathway

Question 4

name this pathway?

activated by surface molecules-microbes (1st line of defense)

Answer 4

alternate pathway

Question 5

name this pathway?

activated by MBL binding to mannose on microorganism

Answer 5

lectin pathway

Question 6

anaphylactoxins consist of?

Answer 6

C3a and C5a

C3b and C5b

Question 7

both of these induce degranulation of mast cells and basophils leading to histamine and more edema

Answer 7

C3a and C5a

Question 8

activates the lipooxygenase pathway of arachidonic acid metabolism and this makes and is an important chemotactic factor for neutrophils and monocytes

Answer 8

C5a

Question 9

this is a mark for recognition and destruction by phagocytosis

Answer 9

C3b (opsonins)

Question 10

this is the cornerstone for MAC

Answer 10

C5b

Question 11

MAC consists of?

Answer 11

C5b-C9

Question 12

how is complement system regulated?

Answer 12

spontaneous decay of components

proteolytic inactivation of components

binding of active components which inactivates them

cell membrane associated molecules

Question 13

makes vasoactive peptides from plasma proteins call kininogens

Answer 13

kinin system

Question 14

what is the kinin system activated by?

Answer 14

hangman factor (XIIa)

Question 15

what causes release of bradykinin which:

Answer 15

increases vascular permeability

contracts SM

vasodilates

PAIN

Question 16

what are the important factors in the clotting system?

Answer 16

thrombin
factor Xa
factor XIIa