TYPE III IMMUNE COMPLEX

Question 1

what are the types?

Answer 1

systemic

localized

Question 2

systemic type III immune complex phases?

Answer 2

formation of antigen-antibody complexes in circulation

deposition of immune complexes in various tissues

immune complex mediated inflammation and tissue injury

Question 3

this is a prototype of systemic immune complex disease, no longer common 5 days after foreign protein is injected, specific antibodies are produced forming complexes that deposit in blood vessels in various tissue beds with an inflammatory reaction triggered

Answer 3

acute serum sickness

Question 4

what are the several variables that determine whether the immune complex formation leads to tissue deposition and disease

Answer 4

size of immune complexes
charge of complex
valency of antigen
avidity of antibody 
high hemodynamic pressures present in the glomeruli and synovium

Question 5

name this type of type III complex is also known as Arthus reaction, localized area of tissue necrosis resulting from acute immune complex vasculitis after antigen is injected into skin

skin lesions evolve
activates and depletes complement C3 & C4

Answer 5

localized

Question 6

name this type of type III complex:

formation of antigen-antibody complexes in circulation

deposition of immune complexes in various tissues

immune complex mediated inflammation and tissue injury

Answer 6

systemic