INFLAMMATORY BIO MARKERS AND CVD RISK PRED

Question 1

biology of plaque rather than degree of stenosis as an important feature in determining plaque stability

Answer 1

atherosclerosis

Question 2

inflammatory markers for CV risk?

Answer 2

CRP
cell adhesion molecules
-ICAM-1, VCAM-1
cytokines: TNF-alpha, IL-6

Question 3

currently used inflammatory markers?

Answer 3

CRP, strongest predictor of risk in univarate analysis

Question 4

future inflammatory markers to note?

Answer 4

myeloperoxidase

glutathione perioxidase 1

Question 5

name this future inflammatory marker?

patients with chest pain, predicted risk of major cardiac event within 30 days adn 6 months, works in absence of myocardial necrosis

Answer 5

myelperoxidase

Question 6

name this future inflammatory marker?

cellular antioxidant enzyme
strong inverse correlation with risk of CV events in patients with CAD

Answer 6

glutathione peroxidase 1