ABNORMAL WBC MORPHOLOGY Flashcards
types of abnormal WBC morphology?
Auer rods
toxic granulation
dohle inclusion bodies
hypersegmentation
linear or spindle shaped red-purple inclusions in blasts or promyelocytes
derivatives of azurophilic granules
usually seen in pathologic conditions (AML)
Auer rods
dark blue to purple cytoplasmic granules, peroxidase positive
found in severe infections or other toxic conditions
toxic granulation
small oval inclusions in the peripheral cytoplasm of neutrophils which stain pale blue with wrights stain
remnants of free ribosomes or rough ER
frequently accompanies toxic granulation
dohle inclusion bodies
normal neutrophils have 2-5 lobes connected by a thin chromosome strand
hypersegmentation occurs if:
>5% of neutrophils have 5 lobes or more
1% of neutrophils have 6 lobes or more
seen in?
hypersegmentation
megaloblastic anemia, B12 deficiency