ANTIBODY MEDIATED DISEASES

Question 1

name this disease

red cell membrane proteins (Rh blood group antigens, I antigen)

hemolysis anemia

Answer 1

autoimmune hemolytic anemia

Question 2

name this disease

platelet membrane proteins (GpIIb/IIIa integrin)

bleeding

Answer 2

autoimmune thrombocytopenia purpura

Question 3

name this disease

proteins in intercellular junctions of epidermal cells (epidermal desmoglein)

skin vesicles (bullae)

Answer 3

pemphigus vulgaris

Question 4

name this disease

neutrophil granule proteins, presumably released from activated neutrophils

vasculitis

Answer 4

vasculitis caused by ANCA (antineutrophil cytoplasmic antibodies)

Question 5

name this disease

non collagenous protein in basement membranes of kidney glomeruli and lung alveoli

nephritis lung hemorrhage

Answer 5

good pasture syndrome

Question 6

name this disease

streptococcal cell wall antigen; antibody cross reacts with myocardial antigen

myocarditis

Answer 6

acute rheumatic fever

Question 7

name this disease

ACh receptor inhibited

muscle weakness and paralysis

Answer 7

myasthenia gravis

Question 8

name this disease

TSH receptor stimulated

Answer 8

graves disease or hyperthyroidism

Question 9

name this disease

insulin receptor inhibited by antibody

Answer 9

hyperglycemia ketoacidosis

Question 10

name this disease

intrinsic factor of gastric parietal cells

abnormal erythropoiesis, anemia

Answer 10

pernicious anemia