ARACHIDONIC ACID METABOLITES

Question 1

steroids inhibit this so that arachidonic acid is formed from cell membrane phospholipids?

Answer 1

phospholipase

Question 2

what are the two main products of arachidonic acid?

Answer 2

cyclooxygenase

5-lipoxygenase

Question 3

what inhibits cyclooxyrgenase, as a result this prevents blood clotting?

Answer 3

NSAIDs

Question 4

what is 5-lipoxygenase activated by?

Answer 4

C5a

Question 5

cyclooxygenase produces? all come from?

Answer 5

prostacyclin PGI2-vasodilation

thromboxane A2-vasoconstriction

PGD2/PGE2 for vasodilation, increased vascular permeability

prostaglandin H2

Question 6

5-lipooxygenase produces?

Answer 6

5 HPETE to 5-HETE, 12 lipooxygenases, Leukotriene A4

Question 7

leukotriene A4 with chemotaxis produces?

Answer 7

leukotriene B1

Question 8

12-lipooxygenases produces?

Answer 8

lipoxin A4 and lipoxin B4 which inhibit neutrophil adhesion and chemotaxis

Question 9

LTC4, LTD4, LTE4 come from? affect?

Answer 9

LTA4

bronchospasm increased and vascular permeability

Question 10

which lipooxygenase causes chemotaxis?

Answer 10

leukotriene B4

Question 11

what triggers PAF release?

Answer 11

phospholipase A2