HYPERCOAGULABILITY

Question 1

primary hyper coagulability is genetic or acquired?

Answer 1

genetic

Question 2

secondary hyper coagulability is genetic or acquired?

Answer 2

acquired

Question 3

what are the examples of primary hyper coagulability?

Answer 3

factor V mutation 
prothrombin mutation
antithrombin III deficiency
protein C or S deficiency 
defects in fibrinolysis

Question 4

what are the examples of secondary hyper coagulability?

Answer 4

immobilization 
myocardial infarction
tissue damage (surgery)
cancer
lupus anticoagulant
late pregnancy and delivery
oral contraceptives
thrombocytopenia

Question 5

leiden mutation is what mutation?

Answer 5

factor V mutation

Question 6

5-fold increased risk of venous thrombosis

Answer 6

heterozygotes factor V mutation

Question 7

50-fold increased risk of venous thrombosis

Answer 7

homozygous factor V mutation

Question 8

increased thrombin circulating resulting in amplification of coagulation cascade/clotting mechanisms

Answer 8

prothrombin mutation

Question 9

acts with heparin to cause anti-coagulant effects (Vii K independent)

Answer 9

antithrombin III deficiency

Question 10

increased risk of DVT, made in the liver and required vitamin K to function

Answer 10

protein C or S deficiency

Question 11

can’t break down clots

Answer 11

defects in fibrinolysis