DEMYELINATING DISEASE

Question 1

Autoimmune demyelinating disorder characterized by distinct episodes of neurologic deficits, separated in time, attributable to white matter lesions that are separated in space. Relapsing and remitting flare-ups, episodes of neurologic deficit during variable intervals of time, followed by gradual/partial remission

Answer 1

multiple sclerosis

Question 2

occurrence?

also what gene

Answer 2

people far from equator
first degree relative

HLA-DR2

Question 3

initiated by what cells?

these lymphocytes are found in what lesions?

Answer 3

CD4+ T-cells

CD4+ & CD8+ lymphocytes

Question 4

morphology?

Answer 4

Plaques in white matter

active plaques
inactive plaques

Question 5

clinical findings of the CSF?

what is present during active lesions?

Answer 5

mildly increased protein w/ oligoclonal bands (IgG)

MBS (myelin basic protein)

Question 6

major clinical findings?

Answer 6

Relapsing and remitting flare-ups: episodes of neurologic deficit during variable
intervals of time, followed by gradual partial remission