CELLULAR REPAIR TERMS

Question 1

present in the spaces between cells in connective tissue between epithelia and supporting vascular and smooth muscle

Answer 1

interstitial matrix

Question 2

found around epithelial cells, endothelial cells and smooth muscle cells

Answer 2

basement membrane

Question 3

most common fibrous structural protein

Answer 3

collagen

Question 4

name this fibrillar collagen type?

ligaments, bone, skin and just about everywhere

Answer 4

type I

Question 5

name this fibrillar collagen type?

articular cartilage

Answer 5

type II

Question 6

name this fibrillar collagen type?

initial collagen for repair until type I collagen replaces it

Answer 6

type III

Question 7

name this nonfibrillar collagen type?

basement membranes

Answer 7

type IV

Question 8

large multifunctional glycoprotein

Answer 8

fibronectin

Question 9

most abundant glycoprotein in basement membrane

Answer 9

laminin

Question 10

major cell surface receptors that mediate cellular attachment to the ECM and also mediate cell cell interactions

Answer 10

integrins

Question 11

protein core linked to polysaccharides

Answer 11

proteoglycans

Question 12

binds to collagen, fibronectin and thrombospondin to modulate GF activity

Answer 12

syndecan

Question 13

found in ECM, serves as ligand for core protein

Answer 13

hyaluronon

Question 14

blood supply key to healing

Answer 14

angiogenesis

Question 15

name this type of scar (early or mature)

lots of tiny leaky immature blood vessels with few collagen fibers separated by edema

Answer 15

early scar

Question 16

name this type of scar (early or mature)

lots of collagen fiber deposition with little/no edema with decrease number of new blood vessels as compared to early scar

Answer 16

mature scar

Question 17

occurs with granulation tissue framework, excessive deposition of collagen and other ECM components in the event of chronic disease (chronic inflammation)

Answer 17

fibrosis

Question 18

rupture of a wound

Answer 18

wound dehiscence

Question 19

occurs due to inadequate intrinsic blood supply (inadequate vascularization)

Answer 19

ulceration

Question 20

aberration of cell growth (increased collagen deposition, genetic)

Answer 20

keloid and hypertrophic scar

Question 21

this scar (keloid or hypertrophic) stay within boundaries of the original wound and generally develop after thermal or traumatic injury that involves deep layers of the dermis

Answer 21

hypertrophic scars

Question 22

this scar (keloid or hypertrophic) extends beyond site of original wound and do not regress spontaneously

Answer 22

hypertrophic scar

Question 23

this scar (keloid or hypertrophic) extends beyond site of original wound and does not regress spontaneously

Answer 23

keloids

Question 24

this is exuberant growth (proud flesh) of granulation tissue which protrudes above surface of skin blocking basal layer to prevent re-epithelization

Answer 24

exuberant granulation

Question 25

these are desmoids that lie in the interface between benign proliferation and low grade malignant tumors

Answer 25

aggressive fibromatoses (desmoids)

Question 26

exaggeration of the process of wound contracture in secondary union resulting in deformities of the would and the surrounding tissue - compromises the movement of joints - palms, soles, burns

Answer 26

contractures

Question 27

name this intention? minimal tissu loss narrow defect clean-no significant bacterial contamination

Answer 27

1st intention (primary union)

Question 28

name this intention? larger tissue defect more intense inflammtory reaction larger amounts of granulation tissue wound contraction-myofibroblasts pull edges of wound trying to make it smaller, appears as puckering

Answer 28

2nd intention (secondary union)