FIRST AID Flashcards
this helper T cell secretes IFN gamma
Th1 cell
this helper T cell secretes IL-4, 5,10,13
Th2 cell
these kill virus infected, neoplastic, and donor graft cells by inducing apoptosis
release cytotoxic granules containing preformed proteins
cytotoxic T cells have CD8
cytotoxic T cells
help maintain specific immune tolerance by suppressing CD4 and CD8 T cell effector functions
ID by expression of CD3, CD4, CD25 and FOXP3
activated reg T cells produce anti inflammatory cytokines
reg T cells
APCs B cells Macs dendritic cells
signals required for T cell activation, B cell activation and class switching
T and B cell activation
complement activation pathway
IgG or IgM mediated
classic pathway
complement activation pathway
microbe surface molecules
alternative pathway
complement activation pathway
mannose or other sugars on microbe surface
lectin pathway
these are the two primary opsonins in bacterial defenses
C3b and IgG
decay accelerating factor (DAF) and CI esterase inhibitor
inhibitors
name this complement disorders
causes hereditary angioedema due to unregulated activation of kallikren to increase bradykinin. ACE inhibitors are contraindicated
C1 esterase inhibitor deficiency
name this complement disorders
increases risk of severe, recurrent pyogenic sinus and respiratory tract infections; increase susceptibility to type III hypersensitivity reactions
C3 deficiency
name this complement disorders
terminal complement deficiency increases susceptibility to recurrent Neisseria bacteremia
C5-C9 deficiencies
name this complement disorders
causes complement mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria
DAF (GPI-anchored enzyme) deficiency
