IMPORTANT GENES

Question 1

what are the important governors/promotors that are involved in classic tumor suppressors?

Answer 1

RB gene involved in the TGF-B pathway

Question 2

what are the guardians/caretakers that sense genomic damage

Answer 2

p53 (TP53)

Question 3

what are the pro apoptotic genes? upregulated by?

this one promotes release of cytochrome c from the mitochondria

Answer 3

BAX and BAK
TP53

BAX

Question 4

what are the anti apoptotic genes?

activated by? on what chromosome?

Answer 4

BCL2 and BCL-X

translocation on chromosome 14

Question 5

these are the family proteins that regular balance between apoptotic molecules

Answer 5

BH-3

Question 6

this growth inhibitory factor binds to cell membrane and inhibits growth

this gene is indicated in breast cancer

Answer 6

BRCA-1

Question 7

these are molecules that regulate adhesion leading to loss of gene presumably interfering with communication between cells and their environment resulting in altered differentiation and proliferation

this gene is inactivated in most colon cancers and in cancers of breast, prostate, pancreas and endometrium

Answer 7

DCC

Question 8

best known cancer tumor suppressor genes

indicated in retinoblastoma

Answer 8

RB

Question 9

mutations of this gene found in many types of cancers, rarely familial, usually sporadic

normally, when DNA is damaged, levels of TP53 protein product increase, arresting the cell in G1

Answer 9

TP53 protein via p53 gene

Question 10

activation of apoptosis is induced via these genes?

Answer 10

BAX and BAK