TYPE IV T-CELL MEDIATED

Question 1

this type of hypersensitivity is initiated by specifically sensitize T cells?

Answer 1

type IV T-cell mediated

Question 2

what are the two types?

Answer 2

delayed type hypersensitivity

T cell mediated cytotoxicity

Question 3

name this type:

develops in response to antigen challenge in previously sensitized individual

reaction delayed for 12-48 hours

mediated by CD4+ cells

TB, fungi, protozoa, contact skin sensitivity

graft rejection

edema, fibrin deposition
-can use the tuberculin skin test (PPD)

Answer 3

delayed type hypersensitivity

Question 4

name this type:

sensitized CD8+ cells kill antigen bearing target cells

mediated by CD8+ cytotoxic T cells

respond to viral infection and tumor cells

perforin granzyme system

Answer 4

T cell mediated cytotoxicity

Question 5

this binds to the plasma membrane of target cell and promotes entry of the granzyme

Answer 5

perforin

Question 6

proteases that cleave and thereby activate cellular caspases to apoptosis

Answer 6

granzymes