IRON DEFICIENCY ANEMIA

Question 1

most common nutritional deficiency worldwide (10% developed; 25-50% underdeveloped)

Answer 1

iron deficiency anemia

Question 2

reasons for infants, children?

Answer 2

low intake, growth spurts

Question 3

reasons for pre-menopausal women?

Answer 3

pregnancy, menstrual loss

Question 4

reasons for adult men & post menopausal women?

Answer 4

chronic blood loss, malabsorption, low intake

Question 5

iron absorption variables?

GI factors:

Answer 5

infection, inflammation of GI tract

malabsorption due to gastrectomy

impact of congested drugs

clay eating, prolonged achlorydia

Question 6

iron absorption is increased by? Decreased by?

Answer 6

vitamin C

tannic acid in tea

Question 7

what are the physiologic factors?

Answer 7

absorption increased if iron stores low or increased RBC synthesis

Question 8

role of GI epithelium in the context of iron physiology?

Answer 8

ferric reductase

divalent metal transporter 1 transports Fe2+

ferroportin transports iron across basolateral membrane
-transferrin, increases when serum levels are low

Question 9

measurement of iron based on?

Answer 9

serum iron
total iron binding capacity
transferring saturation
serum ferritin

Question 10

what are the labs of iron deficiency?

Answer 10

bone marrow and low serum iron

serum ferritin decrease

transferrin saturation decrease

increase total iron binding capacity

Question 11

clinical presentation?

Answer 11

microcytic
elevated RDW
increased platelets
atrophic glossitis
spoon nails 
pica syndrome

Question 12

treatment?

Answer 12

address underlying disease process

strongly consider occult blood loss