MODERN CLASSIFICATION

Question 1

mutated proteins represent antigens that have never been seen by the immune system and thus can be recognized as non self

• mutated oncogenes and tumor suppressor genes
• other mutated genes

Answer 1

products of mutated genes

Question 2

produced at low levels in normal cells and over expressed in tumor cells eliciting immune response

Answer 2

over expressed or aberrantly expressed cellular proteins

Question 3

viruses produce proteins that are recognized as foreign?

what are the most potent of these antigens produced?

Answer 3

tumor antigens produced by oncogenic viruses

latent DNA viruses
-HPV and EBV

Question 4

expressed at high levels on cancer cell and in normal developing (fetal) but not adult tissues

genes silenced during development and are derepressed upon malignant transformation

Answer 4

oncofetal antigens

Question 5

tumors express molecules that are normally present on the cells of origin (self antigens) therefore they do not induce immune response but serve as potential targets for immunotherapy and for identifying the tissue of origin of tumors

Answer 5

cell type specific differentiation antigens

Question 6

what are the types of modern classification?

Answer 6

products of mutated genes

over expressed or aberrantly expressed cellular proteins

tumor antigens produced by oncogenic viruses

oncofetal antigens

altered cell surface glycolipids and glycoproteins

cell type-specific differentiation antigens