Cross Species - Top 20 Toxicosis Part 1 Flashcards
what animals are most often affected by lead toxicosis?
usually dogs or cattle
what is the classic case presentation of acute lead toxicosis in ruminants?
especially in young cows - ataxia, blindness, eyelid twitching, salivation, jaw chomping, bruxism, muscle tremors, & convulsions
what is the classic case presentation of subacute lead toxicosis in ruminants?
especially in sheep & older cows - anorexia, rumen stasis, colic, constipation followed by diarrhea, blindness/head pressing, hyperesthesia, incoordination, & bruxism
what is the classic case presentation of chronic lead toxicosis in ruminants?
dysphagia & aspiration pneumonia
what is the classic case presentation of lead toxicosis in dogs?
anorexia, vomiting, diarrhea, constipation, anxiety/barking, salivation, blindness/ataxia, muscle spasms, opisthotnus, & convulsions
what is the classic case presentation of lead toxicosis in horses?
chronic weight loss, dysphagia, diarrhea, & roaring
what is seen on a CBC from an animal with lead toxicosis?
anemia, anisocytosis, poikilocytosis, polychromasia, basophilic stippling, metarubricytes, & hypochromasia
how is lead toxicosis diagnosed?
blood lead concentration over 0.05-0.10 ppm
what treatment is used for all animals with lead toxicosis? what about specific treatment for dogs?
calcium disodium edetate & thiamine, dogs - d-penicillamine or succimer
what is the pathophysiology of lead toxicosis?
capillary damage/edema with irritation, immune suppression, nephrotoxic, toxic to hematopoietic system, & teratogenic
what animals are often affected by selenium toxicosis?
grazing animals most often affected - all animals are susceptible
what is the classic case presentation of acute selenium toxicosis?
weird behavior, respiratory trouble, tachycardia, frothy nasal discharge, gi upset, & sudden death
what is the classic case presentation of subchronic selenium toxicosis in pigs?
ataxia, paraparesis followed by tetraplegia, poor hooves, & alopecia
what is the classic case presentation of chronic selenium toxicosis?
rough/brittle hair coat, poor hooves/laminitis, & weakness/anorexia
how is selenium toxicosis diagnosed?
high selenium concentration in feed, blood, & tissues
what treatment is indicated for acute selenium toxicosis?
n-acetylcysteine to improve systemic glutathione levels
what treatment is indicated for chronic selenium toxicosis?
high protein diet to bind selenium or add arsenic salt to enhance biliary excretion
what is the pathophysiology of selenium toxicosis?
directly inhibits cellular oxidation/reduction reactions, increases oxygen free radicals causing tissue damage, & alters protein formations/cellular bonds affecting their function
T/F: selenium has a narrow margin of safety
TRUE
T/F: selenium can be found in pasture, hay, grains, & supplements
TRUE