Canine Flash Notes - Renal Physiology Flashcards
what is azotemia? what are the different types & why is it important to characterize?
increase in BUN and/or creatinine
pre-renal, renal, & post-renal
important for accurate diagnosis, treatment, & prognosis
what is uremia?
clinical syndrome resulting from the accumulation of metabolic waste products due to renal failure
what is pre-renal azotemia? what is seen on lab values?
reduced renal perfusion - often caused by dehydration
increased BUN, creatinine, & USG over 1.030
what is renal azotemia? what is seen on lab values?
loss of 75% of nephrons
increased BUN, creatinine, & USG < 1.017
what is post-renal azotemia? what is seen on lab values?
blockage of urine outflow
increased BUN & creatinine, oliguria or anuria, & hyperkalemia
what is the pathophysiology of pre-renal azotemia? what happens if it remains uncorrected? sequela?
decreased renal perfusion causing a decrease in glomerular filtration of metabolites which results in an increase in BUN & creatinine while urine concentrating ability remains normal (normal tubular function)
renal ischemia & kidney destruction - renal disease or renal failure
what is the pathophysiology of renal azotemia?
GFR decreases due to loss of at least 75% of nephrons - renal disease results in azotemia, which eventually causes renal failure
acute renal failure - reversible or irreversible
chronic renal failure - irreversible
how do you treat pre-renal azotemia?
restore circulating fluid volume & renal perfusion, correct electrolyte abnormalities, & treat cause (dehydration, shock, addison’s, etc)
what is the prognosis of pre-renal azotemia?
usually, kidneys will resume normal function when re-perfusion is re-established if there is not prolonged ischemia
what are the 4 main causes of pre-renal azotemia?
- dehydration
- shock
- hypoadrenocorticism
- heart failure
what is the pathophysiology of post-renal azotemia?
blockage of urinary outflow & hyperkalemia develops as it can’t be eliminated
life threatening effects - cardiac conduction (bradycardia & death)
initially kidneys resume normal function if corrected, but too much time with obstruction can result in acute renal lesion (hydronephrosis)
what is the classic case presentation of a dog with renal azotemia? what lab changes are seen?
acute - anuric/oliguric, occasionally polyuric
chronic - pu/pd, gi signs (vomiting/diarrhea), & oral ulcers
increase in BUN/creatinine & low specific gravity
what are some causes of acute renal failure in dogs?
pre-renal ischemia from dehydration/hypovolemia, ethylene glycol toxicity, aminoglycoside toxicity, heavy metal toxicity, hypercalcemia, leptospirosis
chronic renal disease resulting in failure
how is renal azotemia treated?
acute - supportive care until it repairs itself (fluids, treat hyperkalemia, treat acidosis)
chronic - no cure, palliative care, fluids, & diet restricted proteins & phosphorus (hill’s k/d)
what is the classic presentation of an animal with post-renal azotemia? sequela?
oliguria, straining to urinate, abdominal discomfort
heart failure from hyperkalemia & hydronephrosis
what are the main causes of post-renal azotemia?
obstruction - calculi in renal pelvis/ureter/urethra, tumor block, entrapment of urinary tract from a hernia, trauma, stricture, or iatrogenic from surgery or catheterization
ruptured urinary tract
how is a diagnosis of post-renal azotemia made based off of lab changes?
increased BUN/creatinine, ECG shows bradycardia, spiked t waves, absent p waves
check creatinine of abdominal fluid if rupture is suspected
how is post-renal azotemia treated?
hyperkalemia addressed first!!!
unblock the animal - cystocentesis if you can’t immediately unblock
fluids - sodium bicarb 0.5-1.0 mmol/kg slow IV over 15 minutes, 20% dextrose 0.5-1.0 g/kg IV with </= 1 unit of regular insulin per 3 grams of dextrose, or 10% calcium gluconate up to 0.5-1.0 g/kg IV
what values designate an animal as being polyuric/polydipsic?
urine production > 25ml/lb/day (more than 50 ml/kg/day)
water consumption > 50 ml/lb/day (more than 100 ml/kg/day)
T/F: pu/pd is a manifestation of a disease & not a diagnosis
true
what is the mechanism of polydipsia?
low plasma osmolality stimulates chemoreceptors in the thirst center - posterior pituitary gland releases ADH
renal response to ADH is to concentrate urine requiring 1/3 functioning nephrons & a hypertonic renal medullary interstitium (2/3 non-functional nephrons for kidney not to concentrate urine causing polyuria)
what is the common presentation of an animal that is pu/pd?
nocturia, inappropriate urination, incontinence, pollakiuria, & polydipsia
what urine production metabolism rate is used for a caged animal?
urine volume 25-45 ml/kg/24 hours
if a pu/pd dog has a usg of 1.040, what do you think? what if it is less than 1.007? what if it is 1.025 or higher with pu/pd?
1.040 - unlikely to be polyuria
1.007 - hyposthenuria, tentative diagnosis of central diabetes insipidus, nephrogenic diabetes insipidus, or pituitary diabetes insipidus
1.025 - suggests hypoadrenocorticism, diabetes mellitus, or renal glucosuria
how is a water deprivation test used to diagnose disease in a pu/pd dog with no other signs of systemic disease?
if USG is over 1.025, suspect psychogenic polydipsia or cushing’s
if under 1.025, proceed with an ADH test
what tests are used to differentiate normal psychogenic polydipsia, hyperadrenocorticism, pituitary diabetes insipidus, nephrogenic diabetes insipidus, or medullary washout?
water deprivation tests, ADH test, gradual H2O test, & ADH + gradual H2O deprivation tests
how are results of an ADH test interpreted for an animal with pu/pd?
if USG is over 1.025 - pituitary diabetes insipidus, no ADH
if USG less than 1.025 - proceed with gradual H2O deprivation test
what is the point of doing a gradual H2O test on a pu/pd dog?
correct possible medullary wash out
how are results of an gradual H2O test interpreted for an animal with pu/pd?
if USG is higher than 1.025 - suspect psychogenic polydipsia or cushing’s
if USG is lower than 1.025 - proceed with ADH test
how are results of an ADH + gradual H2O test interpreted for an animal with pu/pd?
if USG is less than 1.025 - kidney unresponsive to ADH
if USG is higher than 1.025 - pituitary diabetes insipidus
what are some differentials for a dog that is pu/pd?
diabetes mellitus, hypoadrenocorticism, primary renal disease, liver disease, pyometra, hypercalcemia, hyperparathyroidism, pituitary diabetes insipidus, & psychogenic polydipsia
what is isosthenuria?
USG of 1.008-1.012 - same as plasma
what is hyposthenuria?
USG < 1.007, inability to concentrate urine
what are the minimal concentration ranges of USG in dogs & cats?
dogs: 1.013-1.030
cats: 1.013-1.035
what is the point of doing a water deprivation test on a pu/pd animal? what are the contraindications to doing it?
determines if ADH is released in response to subclinical dehydration
if kidneys can respond to ADH & concentrate urine
contraindications - dehydration, azotemia (BUN, creatinine), or hypercalcemia
when do you terminate a water deprivation test?
urine concentration > 1.025, > 5% weight loss, azotemia develops, dehydration develops
what is the benefit of doing a gradual water deprivation test?
for animals with psychogenic polydipsia with medullary washout (animal can’t concentrate on abrupt test), so this allows the gradient to be re-established
how is a gradual water deprivation test done?
reduce water intake bt 5% daily
what is a negative result for a gradual water deprivation test?
animal fails to concentrate without renal disease or lab abnormalities - indicates neurogenic or nephrogenic diabetes insipidus
when is an ADH response test done?
done after abrupt or gradual water deprivation test if there is an inadequate concentration
tests renal tubular ability to concentrate urine
how is an ADH response test done? how are the results interpreted?
vasopressin is given IM & USG is measured at 30, 60, 90, & 120 minutes
negative water deprivation test + positive ADH concentration >1.025 - diagnostic for neurogenic diabetes insipidus
both negative water deprivation & ADH response tests - indicate nephrogenic diabetes insipidus or DDI if after abrupt H2O deprivation
what is a negative result of an abrupt H2O deprivation test?
failure to concentrate, USG < 1.025 without renal disease or other lab abnormalities - indicates neurogenic or nephrogenic diabetes insipidus and/or medullary washout
what are the 3 main types of diabetes insipidus & their basic pathophysiology?
- nephrogenic - partial or complete renal tubule insensitivity to ADH
- central - partial or complete primary deficiency of ADH
- dipsogenic/psychogenic - excessive water intake
what are the main causes of nephrogenic diabetes insipidus?
acquired secondary - renal & metabolic disorders affecting renal tubules’ ability to respond to ADH (most acquired forms are reversible following correction of the cause)
primary causes - acute renal failure, hydronephrosis, chronic pyelonephritis, fanconi’s syndrome
secondary causes - pyometra, DM, liver disease, lymphoma, cushing’s, addison’s, hyperthyroidism
what metabolic changes can result in nephrogenic diabetes insipidus?
hypercalcemia & hypokalemia
what drugs are implicated as causes of nephrogenic diabetes insipidus?
steroids, anticonvulsants, & diuretics
how is nephrogenic diabetes insipidus diagnosed?
negative H2O & ADH test - both tests have a USG result of < 1.025