Cross Species Top 10 Reportable Diseases - Part 1 Flashcards

1
Q

what species are affected by foot-and-mouth disease? what species are not?

A

affected - cattle, goats, sheep, & pigs

not affected - HORSES!!!!!

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2
Q

what is the classic case presentation of an animal with foot-and-mouth disease?

A

painful vesicles/erosions on tongue/muzzle/gums/teats/between claws/coronary bands, high fever, drooling thick sticky saliva with lip smacking, lameness, abortions, & fast spread between animals

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3
Q

T/F: situation determines what diagnostic test to use for potential cases of foot-and-mouth disease

A

true

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4
Q

what is the etiology of foot-and-mouth disease?

A

aphthovirus of the picornaviradae family with 7 serotypes

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5
Q

what tests are used to diagnose foot-and-mouth disease? what samples are submitted?

A

tests - ELISA, PCR, virus isolation, electron microscopy, or complement fixation

samples - vesicular fluid, epithelium, exudates, pharyngeal/esophageal fluid, milk, semen, & blood

approved labs do initial testing & special reference labs do confirmatory testing

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6
Q

what treatment is used for foot-and-mouth disease?

A

NONE - kill all affected/in contact

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7
Q

what preventative measures are used for foot-and-mouth disease?

A

euthanize all positive & in contact animals - bury or burn carcasses

maintain strict movement/entry requirements

quarantine +/- vaccination - killed vaccine provides 4-6 months immunity

thorough disinfection of premises/equipment - disinfectant with a pH less than 6 or greater than 9

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8
Q

what is the prognosis for animals with foot-and-mouth disease?

A

good for infected individuals

poor for overall herd health & economic outcome

guarded in neonates & nursing animals

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9
Q

_______-___-______ disease is one of the most contagious animal diseases known & is reportable worldwide due to its severe economic impact & production losses

A

foot-and-mouth

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10
Q

if you see these ulcers on a cow’s tongue that has signs of lameness, heavy drooling, and a high fever, what should you test for?

A

foot-and-mouth

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11
Q

what disease is the ‘evil twin’ to foot-and-mouth disease?

A

vesicular stomatitis

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12
Q

what species are affected by vesicular stomatitis? what environment & age group is more commonly implicated?

A

CATTLE & HORSES - occasionally swine, camelids, & rare in sheep/goats

warm humid areas in the western hemisphere - adult animals over 1 year of age

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13
Q

what is the classic case presentation of an animal with vesicular stomatitis?

A

fever, salivation, difficulty eating, vesicles/erosions/ulcers on mouth/lips/teats/coronary band, hyperemic skin or raised blanched areas in the mouth, variable morbidity with low mortality

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14
Q

what is the etiology of vesicular stomatitis?

A

rhabdoviridae family genus vesiculovirus with 2 serotypes - new jersey & indiana

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15
Q

how is vesicular stomatitis transmitted?

A

transmission by insects (sand/black flies, mosquitos) or direct contact with saliva, epithelium, exudates, or fomites

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16
Q

how is vesicular stomatitis diagnosed?

A

ELISA most common - used to identify the viral antigen or antibody

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17
Q

what treatment is used for vesicular stomatitis?

A

symptomatic care - soft feed, bedding, analgesia, & +/- antibiotics

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18
Q

what preventative measures are used for vesicular stomatitis?

A

QUARANTINE FARM!!! isolate affected animals, sanitation/disinfection, insect control, & vaccines

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19
Q

T/F: mortality from vesicular stomatitis is rare, but economic losses are significant

A

true

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20
Q

for an animal with vesicular stomatitis, what other diseases cannot be distinguished from it by clinical signs alone?

A

foot-and-mouth, swine vesicular disease, or vesicular exanthema of swine

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21
Q

what are the 8 big rule outs for vesicular diseases?

A
  1. bluetongue
  2. bovine papular stomatitis
  3. bovine viral diarrhea virus
  4. foot-and-mouth disease
  5. infectious bovine rhinotracheitis
  6. malignant catarrhal fever
  7. rinderpest
  8. vesicular stomatitis
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22
Q

T/F: pigs are the only animals affected by classical swine fever

A

true

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23
Q

what factors cause a varying severity of classical swine fever?

A

age - young animals are most severe with high mortality

immune status of the herd

strain of the virus

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24
Q

what is seen in the classic case presentation of the acute form of classical swine fever?

A

high fever > 105°F, anorexia, constipation followed by diarrhea, cyanosis, erythema, skin hemorrhages, staggering, incoordination, posterior paresis, seizures, & death within 1-3 weeks

some cases are asymptomatic and are inapparent carriers

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25
Q

what are some things that should make you suspect classical swine fever?

A

septicemia, high fever, incoordination, diarrhea, & death

history of feeding garbage, new/returning animals to the herd

NO response to treatment

cases on a nearby farm

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26
Q

what is seen on necropsy that is supportive of classical swine fever?

A

widespread hemorrhages

turkey egg kidneys with pinpoint hemorrhages

necrotic foci on the intestinal mucosa, larynx, & epiglottis

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27
Q

what test is used for surveillance of classical swine fever?

A

RT-PCR

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28
Q

what treatment is used for classical swine fever?

A

NONE! do not treat positive pigs!!!!

reportable - notify federal & state veterinarians!!!! quarantine farm until definitive diagnosis is made, & isolate suspected CSF-animals

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29
Q

how is classical swine fever prevented?

A

NEVER feed pigs undercooked garbage (swill) or pork products

quarantine newly purchased or returning animals for a minimum of 30 days

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30
Q

what are the main sources of infection for classical swine fever?

A

carrier pigs & feeding garbage

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31
Q

T/F: classical swine fever is DISTINGUISHABLE from african swine fever

A

false - clinically INDISTINGUISHABLE

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32
Q

if you see the pictured lesion on necropsy of a pig, what disease should you suspect?

A

classical swine fever

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33
Q

what is the morbidity/mortality of the acute form of classical swine fever?

A

100% morbidity/mortality

34
Q

what is the ‘evil twin’ of classical swine fever?

A

african swine fever

35
Q

what is the natural host of african swine fever? what clinical signs do they exhibit?

A

wart hogs - no clinical signs

36
Q

how does african swine fever affect domestic pigs?

A

close contact between domestic pigs & wart hogs through infected ticks

37
Q

what is the etiology of classical swine fever?

A

RNA pestivirus of family flaviviridae

38
Q

what is the classical case presentation of african swine fever?

A

acute form - ear tip hyperemia, scleral hemorrhage, skin cyanosis, hemorrhagic intestines, high fever >105°F, 100% mortality

39
Q

what is the etiology of african swine fever?

A

DNA virus genus asfivirus - only member of the family asfarviridae

40
Q

how is a field diagnosis of african swine fever made? what samples are taken? where are they sent?

A

history & clinical signs - if suspected, report immediately

samples sent only to authorized state diagnostic lab via secure shipping

tonsils are the best sample - other options include kidney, spleen, lymph nodes, & whole EDTA blood

41
Q

what diagnostic test can detect the onset of african swine fever prior to clinical signs?

A

PCR on tonsil scrapings

42
Q

what is the treatment of african swine fever?

A

none - quarantine farm

slaughter all, burn, or bury carcasses

43
Q

what is seen on necropsy of african swine fever?

A

a whole lot of hemorrhage

44
Q

what prevention is used for african swine fever?

A

strict biosecurity & sanitation protocols

importation restrictions on pigs/pork products

never feeding pigs undercooked garbage (swill) or pork products

45
Q

what is the vector that causes african swine fever leading to devastating economic impact?

A

soft ticks that inhabit wart hog burrows

46
Q

what is the classic presentation of bovine spongiform encephalopathy?

A

animal older than 2 years old with an insidious onset of abnormal behaviors - aggression, apprehension, ataxia, tremors, low head carriage, weight loss, & reduced milk yield

47
Q

what is the etiology of BSE?

A

transmissible spongiform encephalopathy that is caused by a misfolded version of a normal cell prion proteins

48
Q

how is BSE tested for with surveillance screening? what about further definitive testing?

A

surveillance - ELISA test

definitive - send to a national veterinary services lab approved for confirmation

49
Q

where can you find a list of approved labs where testing for BSE can be done?

A

national animal health laboratory network

50
Q

what treatment is used for BSE?

A

none - euthanized

51
Q

what prevention is used for BSE?

A

do not feed animal tissues/products to cattle

incineration of infected carcasses is the best method to destroy prions

test all downer cows for BSE

take great care in handling tissues

52
Q

T/F: BSE is ALWAYS fatal

A

true

53
Q

unlike scrapie, what clinical sign isn’t seen in BSE?

A

pruritus

54
Q

how is BSE spread?

A

spread by ingestion - no genetic susceptibility is required

55
Q

is BSE zoonotic? how?

A

YES!!!

linked to variant form of creutzfeldt-jakob disease in humans

56
Q

how would you describe this histopathology lesion taken from a cow with BSE?

A

vacuolar/spongy appearance of gray matter

57
Q

what is the best tissue sample that can be submitted for diagnosing BSE in a cow?

A

obex of the brain

58
Q

what is the common signalment of animal affected by scrapie?

A

adult sheep > 2 years, black faced breeds in USA

seen in goats rarely

59
Q

what is the classic case presentation of a sheep with scrapie?

A

pruritus - sheep rub their skin constantly, wool is scraped off, hypersensitivity reactions

progressive neurologic signs - head tremors, ataxia, bunny hopping, prancing, nibbling at legs & air

behavior changes - separation from the flock, hyperexcitable

weight loss with normal appetite

dead within weeks to months once clinical signs are present

60
Q

what is the etiology of scrapie?

A

misfolded versions of normal cellular proteins - prions (PrPSC)

61
Q

how is scrapie diagnosed? what test is the gold standard? what samples are taken? what tests are used for screening?

A

must detect prion proteins in tissues

IHC is gold standard - looking for vacuoles & plaques

samples - brain tissue most often obex & for atypical scrapie, the cerebellum, lymphoid tissue biopsy of the 3rd eyelid

western blot when tissues are autolyzed

ELISA for screening - brain & lymphatic tissue

62
Q

how is scrapie treated?

A

no treatment - euthanasia

63
Q

how is scrapie prevented?

A

great care in handling & transporting tissues

breed only genetically resistant sheep, do not feed ruminant proteins to sheep, maintain closed herd, euthanize positive sheep, & follow the eradicate scrape guidelines & US mandatory scrapie eradication program

carcasses - incineration or alkaline digestion

64
Q

what is the incubation period of scrapie?

A

2-5 years

65
Q

T/F: because prions are a normal cellular protein, there is no immune response in scrapie

A

true

66
Q

what animals are affected by chronic wasting disease?

A

white tailed deer, mule deer, & elk

67
Q

what is the classic case presentation of chronic wasting disease?

A

white tailed deer, mule deer, or elk - in adults older than 16 months

aspiration pneumonia due to esophageal dysfunction, weight loss, neurologic signs, behavior changes

68
Q

what is the etiology of CWD? how is it diagnosed? what samples are taken for deer & elk?

A

misfolded versions of normal cellular prion proteins (PrPCWD)

detect the prions - ELISA for screening & confirmed with IHC or western blot

deer samples - brainstem/obex, lymphoid tissue, & retropharyngeal lymph nodes

elk samples - brainstem/obex & lymphoid tissues

69
Q

what treatment is used for CWD?

A

none - euthanize

70
Q

what prevention is used for CWD?

A

quarantine animals, test & cull animals, & disposal using incineration or approved disinfectants

71
Q

T/F: for CWD, cooking doesn’t destroy prions from CWD

A

true

72
Q

T/F: horizontal transmission plays a role through direct contact of an infected animal & the environment in CWD

A

true

73
Q

what are the 3 types of EIA? which is the most common?

A
  1. inapparent - most common, no clinical signs
  2. acute - fever, lethargy, thrombocytopenia
  3. chronic - recurrent episodes of fever, anemia, weight loss, ventral edema, & petechiation
74
Q

what is the etiology of EIA?

A

lentivirus from the retroviridae family

75
Q

how is EIA diagnosed? how must testing be done?

A

coggins test - AGID or ELISA

must be performed at a USDA-approved lab & submitted by a licensed & federally accredited veterinarian

76
Q

what treatment is used for EIA?

A

none - euthanize

77
Q

what prevention is used for EIA?

A

euthanizing positive animals, regular testing, insect control

78
Q

what are your options for a horse if they test positive for EIA?

A

can either live isolated at least 200 yards away from other horses or euthanized

79
Q

what mandatory testing is required for EIA in horses?

A

all horses moved interstate or sold within a state must have tested negative for EIA within the last 12 months of the sale/move

80
Q

how is EIA transmitted?

A

transmitted by biting insects or blood transfer