48 Complicações Pos-Tx Abdominal Flashcards

1
Q

Em que população o risco de trombose de arteria hepatica é mais comum apos transplante hepatico?

A

Pediatria (menor calibre do vaso)

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2
Q

Qual fator de risco mais comum para vazamento de bile apos tx hepatico?

A

Enxertos de doadores com morte cardiaca.

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3
Q

Qual a principal causa de morte no periodo pos-op imediato de tx de orgaos solidos?

A

Infeccao

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4
Q

Fatores de risco para infeccao fúngica apos tx figado (6)

A

preexisting viral hepatitis,
diabetes mellitus,
multiple organ system failure,
prolonged parenteral nutrition,
long-term mechanical ventilation,
increased antibiotic use.

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5
Q

Principais imunossupressores utilizados em transplantes de orgaos sólidos nas fases de inducao e manutencao (2)

A

Inibidores de calcineurina

  • ciclosporina
  • tacrolimus

Both agents inhibit transcription of interleukin (IL)-2 and other cytokines, primarily in helper T lymphocytes.

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6
Q

Como agem os inibidores de calcineurina (ciclosporina e tacrolimus)

A

Both agents inhibit transcription of interleukin (IL)-2 and other cytokines, primarily in helper T lymphocytes.

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7
Q

Conduta em caso de azotemia provocada pelos inibidores de calcineurina

A

Reduzir a dose

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8
Q

Drogas utilizadas para reduzir a dose e efeitos colaterais dos inibidores de calcineurina

A
  • Micophenolate mofetil
  • Sirolimus - inibidor de mTOR
  • Basiliximab - ac monoclonal de CD25
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9
Q

O que é o efeito de “privilegio imunológico do figado”?

A

Recipients of liver grafts require less immunosuppression than do recipients of other organs, and liver grafts confer protection on other organs transplanted from the same donor.

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10
Q

Qual imunossupressor nao esta associado a risco de cancer no pos-tx?

A

Sirolimus is not associated with cancer risk, and in fact may have antitumor effects.

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