Noradrenaline Transport system Flashcards
What is the noradrenaline neuronal transport?
In the neuronal membrane
What are the substrates of the noradrenaline neuronal transport system?
TAAM acronym
T- tyramine
A- adrenergic neuron-blocking drugs like phenoxybenzamine
A- amphetamine
M- methylnoradrenaline
What is the order of specificity of the noradrenaline vesicular transport system?
Order of specificity: NA> A > ISO
What inhibits the noradrenaline neuronal transport system?
Inhibited by phenoxybenzamine, tricyclics and amphetamine and cocaine
What is the noradrenaline extra-neuronal transport?
Non neuronal cell membrane
What are the substrates of the noradrenaline extra-neuronal transport system?
Dopamine, serotonin and histamine
What is the vesicular noradrenaline transport system?
Via the vesicular membrane
What is the specificity of the noradrenaline extra-neuronal transport system?
Adrenaline > Noradrenaline > Isoprenaline
What are the inhibitors of the noradrenaline extra-neuronal transport system?
Inhibited by steroid hormone and phenoxybenzamine
What are the substrates of the vesicular noradrenaline transport system?
Dopamine, serotonin and guanethidine
What inhibits the vesicular noradrenaline transport system?
Inhibited by resperine and tetrabenazine