Noradrenaline Transport system Flashcards

1
Q

What is the noradrenaline neuronal transport?

A

In the neuronal membrane

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2
Q

What are the substrates of the noradrenaline neuronal transport system?

A

TAAM acronym
T- tyramine
A- adrenergic neuron-blocking drugs like phenoxybenzamine
A- amphetamine
M- methylnoradrenaline

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3
Q

What is the order of specificity of the noradrenaline vesicular transport system?

A

Order of specificity: NA> A > ISO

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4
Q

What inhibits the noradrenaline neuronal transport system?

A

Inhibited by phenoxybenzamine, tricyclics and amphetamine and cocaine

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5
Q

What is the noradrenaline extra-neuronal transport?

A

Non neuronal cell membrane

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6
Q

What are the substrates of the noradrenaline extra-neuronal transport system?

A

Dopamine, serotonin and histamine

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7
Q

What is the vesicular noradrenaline transport system?

A

Via the vesicular membrane

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8
Q

What is the specificity of the noradrenaline extra-neuronal transport system?

A

Adrenaline > Noradrenaline > Isoprenaline

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9
Q

What are the inhibitors of the noradrenaline extra-neuronal transport system?

A

Inhibited by steroid hormone and phenoxybenzamine

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10
Q

What are the substrates of the vesicular noradrenaline transport system?

A

Dopamine, serotonin and guanethidine

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11
Q

What inhibits the vesicular noradrenaline transport system?

A

Inhibited by resperine and tetrabenazine

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