Block 4 formative feedback Flashcards
Are B or T cells more abundant?
T cells
What is aplastic anaemia?
When the body does not produce enough RBC due to immune system attacking bone marrow.
What is congenital spherocytosis?
RBC with a spherical shape due to mutation. Associated with haemolytic anaemia due to abnormal shape so splenogemaly occurs. Body compensates with increasing reticulocyte production.
What type of anaemia will a patient with low iron and ferritin but high total iron binding capacity indicate?
Microcytic hypochromic anaemia- ferritin which is a store of iron is low so the body attempts to increase its affinity
What type of anaemia will a patient with low iron and low iron binding capacity but normal ferritin indicate?
Normocytic normochromic anaemia. Ferritin which is a store of iron is normal.
What are Langerhan cells?
Antigen presenting cells in the skin
Which complement component is bound by complement fixing antibodies?
C1q is targeted by IgG and IgM.
What is the main site of RBC production in adults?
Pelvis
What is mtor?
Mamillian target receptor rapamycin. This is a kinase receptor for downstream signalling of immune molecules.
What drug targets mtor?
Sirolimus
What is the indication of schistocyte?
Microangiopathic haemolytic anaemia- RBC destruction due to turbulence of circulation through vessels caused by platelet aggregation or fibrin deposition associated with injury
How are T cell receptors produced?
Via somatic recombination which generates all the diversity of T cells
Which cells undergo somatic hypermutation?
B cells
