QUESMED B9 cancer

Question 1

What is the most common cause of bladder and breast cancer?

Answer 1

Inactivation of p53.

Question 2

Which type of cancer has a better prognosis with Philadelphia chromosome?

Answer 2

CML, because it can be treated with imatinib.

Question 3

Which type of cancer has a worse prognosis with Philadelphia chromosome?

Answer 3

AML

Question 4

What is the most common type of cancer i children?

Answer 4

Acute lymphoblastic leukemia

Question 5

What is rituximab used for?.

Answer 5

Autoimmune conditions
B cell related cancers

Question 6

How does rituximab work?

Answer 6

It is a monoclonal antibody which targets the CD20 receptor on B cells.

Immature B cells lack this, which allows the B cell population to regenerate following therapy.

Question 7

How does tamoxifen work?

Answer 7

It is a selective oestrogen modulator which inhibits ER receptors in the breast tissue and increases it in the endometrium, increasing the risk of endometrial cancer.

Question 8

What should methotrexate be co-prescribed with?

Answer 8

Folic acid, to reduce the side effects of inhibiton of DHF reductase.