Block 9 Week 4 Flashcards
Diagnosis of Malaria
Rapid Diagnostic test
Aspergilloma
Pathogenic mould which causes a Fungal ball containing debris and mucus in the lungs
Onycomychosis
Fungal nail infection
Chondroma
Benign tumours found in the cartilage of the hands and feet
Histogenesis
Differentiation of cells into specialised tissues and organs during growth
Malaria life cycle
Exo-erythrocytic stage, erythrocytic stage and sporogonic stage which takes 48 hrs
Variolation
Enhancing immunity by taking substances from infected patients like pus or dried mucus to give to non-infected patients
Which virus has been successfully eradicated?
Smallpox
Which layer of the skin is dermatophyses present?
Stratum corneum
Invasive intestinal ameobiasis
Dysentery and colitis due to mucosal invasion
Ecchinocus granulosus
Cestode which Causes Hyatid disease from dog faeces to -> cattle
Leishmaniasis
Caused by female phlebotomine sandflies with sores at bite location. It classified based on location.
Visceral, Cutaneous and
Anaplastic
Highly undifferentiated, loss of polarity, pleomorphism, abnormal nuclear morphology
Coccidiodes immitis
Dimorphic fungi
Bilharzia
AKA Schistosomiasis, a type of trematode (fluke) which can lead to anaemia, learning difficulties
Examples of nematode
Soil transmitted helminths such as
Ascaris, filiaril roundworms, draculunculus, trichuris trichuria. Matures in the large intestine and causes weight loss, nausea and GI symptoms
Taeniasis
Parasitic cestode (tapeworm) infection found in infected meat such as beef or pork. Causes cysterocisis in localised organs such as the brain.
Metaplasia
Differentiation from one cell type to another due to environmental stressor
Inflammatory infectious conditions that are a sporadic cause of cancer
Hep B:liver cancer
inflammatory bowel disease: bowel cancer
H.pylori: stomach cancer
Pleomorphism
Variation in size and shape
Regulatory genes for cell division
Tumour suppression genes
Apoptosis
Repair gene DNA
proto-oncogenes
Transfer of specific gamma globulins
Tetanus, gangrene, snake bite, Hep B, rabies
Transfer of serum gamma globulins
Maternal antibodies, hypogammaglobinumia
Trichomoniasis
STI parasite caused by infection in the vagina
Ascariasis
Caused by nematode (roundworm) in the soil . They mature in the lungs and ascend bronchial tree causing cough to be swallowed which live in the small intestine for up to 2 years
Leiomyoma
Benign smooth muscle tumour
Non pathogenic gut parasites
Lodamoeba butschilli, entamoeba histolytica, entamoeba coli, endolimax nana
Hamartoma
Benign overgrowth of cells and tissues in a given area. It can undergo malignant transformation.
Elephantitis
Caused by nematode filiaris which causes hardening and thickening of the skin
Uncomplicated malaria
Fever, chills, sweating
Effect of cancer
Reduces angiogenesis
Replication of parasite inside Anopheles
Sexual reproduction
Tinea pedis
Fungal infection in foot
Effect of azole
Causes liver damage
Stage of malaria which causes clinical symptoms
Erythrocytic stage
Helicobacter pylori- cancer
Produces urease -> ammonia + CO2. Ammonia is a carcinogen to cells and causes gastric carcinoma
Routes of metastasis
Haematogenous (blood)
Lymphatic
Transcoelomic via body cavities
Dracunculus medinensis parasite
Guinea worm disease where it Migrates through subcutaneous tissue causing severe joint pain and emerges in the feet
Cancer stage
Spread of tumour
Giardasis
Parasitic disease which causes diarrhoea
Hypersensitivity to fungi
Asthma and farmer’s lung
Exo-erythrocytic stage
Sporozoites infect hepatocytes and mature into schizonts which rupture and release merozoites
Epstein-Barr virus
Herpes virus 4 which induces excess production of WBC and leads to fever, swollen lymph nodes. It is linked to lymphoma and nasopharyngeal cancers
Which type of plasmodium emerges from the liver cells?
Merozoites
Cyclin-dependent kinases
Regulate the cell cycle
Hepatitis B- cancer
Hepatocellular carcinoma
Choristoma
Benign tumour where normal tissue is in a foreign site
South African Trypanosomiasis
Faeces of blood sucking triatomine insect
Cancer
Malignant tumour/neoplasm
Barrett’s oesophagus
Metaplasia due to GI reflux so squamous -> columnar with goblet cells
GUinea worm disease
Dracunculus medinensis
Types of metaplasia
Squamous and glandular
Schistosoma
Trematode (Fluke) Mansoni, jepacium affect intestines, hematobium affects bladder. Caused by swimming in fresh water that leads to inflammation and scarring.
River blindness
Caused by onchocerciasis
Pykonsis
Shrinkage of nucleus due to necrosis
Karryolysis
Dissolution of the nucleus
Karryorhexis
Fragmentation of cell nucleus
How is HIV-1 gene expression from CD4+ T cells reduced?
Histone deacetylation
HPV
Double stranded DNA virus
SARS-CO2
Positive single strand RNA virus
How does SARS-COV2 infect?
Uses the spike protein to bind to the ACE2 (angiotensin converting enzyme) receptor present on the heart and kidney cells leading to severe thrombotic disease
What are the types of COVID 19 vaccines generated?
Artificially producing synthetic mRNA corresponding to the spike
Isolating source of SARS-COV2 spike genetic material
What is produced in the sexual reproduction of fungi?
Hyphae and spores
Coccidiodes immitis
Dimorphic fungi
Tinea versicolour
Superficial mycoses of fungi which interferes with skin pigmentation, leading to rash and skin flaking
Eukaryotic parasites
Protozoa, helminths and arthopods
How do anti-helminths work?
Target the adult non-proliferating organisms
How do helminths lay eggs?
Carbohydrate metabolism and microtubule integrity
How do helminths move food in their digestive tract?
Neuromuscular co-ordination
What form of malaria is ingested by a parasite during a blood meal?
Gametocytes
What is the sporogonic cycle?
Replication of parasite in the mosquito
Quartern malaria
Every 3-4 days for falciparum and malariae
Tertiary malaria
Every 2-3 days for ovale and vivax
Teratoma
Tumour which arises from all embryological germ layers
Which tumours use haematogenous spread?
Liver and lung cancer via venous drainage
Histological grade
Scale of 1-3
Score 1: Small nuclei and slightly bigger cell
Score 2: Larger cells than normal with prominent open vesicular nuclei
Score 3: Vesicular nuclei with prominent nucleoli
Vesicular nuclei
Large nuclei
Temperature for conscious intelligence
35 to 45 degrees
Tympanic membrane monitor
Infared measurement of eardrum temp
Part of the hypothalamus for temp
Anterior hypothalamus
What is a common heart irregularity in hypothermic patients?
J wave caused by displacement of ST segment due to ventricular fibrillation
Nodule
Growth of abnormal tissue which creates a lump under the skin
Wheal
Raised itchy rash