Clinical Aspect Of Stroke Flashcards

1
Q

What is a stroke?

A

Disturbance of cerebral function with symptoms lasting longer than 24 hours due to an issue of vascular Origin, caused by ischaemia or haemorrhage.

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2
Q

What is a transient ischaemic attack?

A

Blood supply from the carotid and vertebra-basilar arteries to the brain is temporarily disrupted which results in a sudden focal loss of neurological function that lasts up to 24 hours. Patients make a full recovery and diagnosis is made retrospectively.

Cannot see infarction on imaging.

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3
Q

What is a mimic?

A

Non-vascular medical conditions which present with similar symptoms as a stroke.

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4
Q

What are chameleons?

A

Stroke which masquerades as an alternative condition.

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5
Q

What are the symptoms of stroke?

A

Weakness, sensory loss and disturbance
Vertigo
Dysarthria
Sudden focal neurological deficit

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6
Q

What is the focal neurological dysfunction?

A

Lesion affecting a specific region of the brain which has an acute onset, and more prevalent in patients with vascular risk factors.

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7
Q

What is the sex presentation of stroke?

A

Men generally have more strokes; women have more mimics

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8
Q

What is assessed in taking a stroke history?

A

Risk factors for atherosclerosis and cardiac disease
Family history
Recent physical trauma
Illegal drug use

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9
Q

What is the blood supply to the regions of the brain responsible for consciousness?

A

Vertebra-basilar arteries- these also supply blood to the regions involved in vision and balance coordination.

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10
Q

What are the hospital assessment tools for stroke?

A

ROSIER: Recognition Of Stroke In Emergency Room
NIHSS: National Insitute of Health Stroke Scale

These are used in a neurological exam to determine if a stroke has occurred and its severity.

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11
Q

What are the pre-hospital assessment tools for stroke?

A

FAST: Face, Arms, Speech, Time
BE-FAST: Balance, Eyes, Face, Arms, Speech, Time

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12
Q

What is the presentation of stroke and ICA?

A

Issues with speech
Vomiting
Visual disturbances
Loss of consciousness

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13
Q

How is a stroke or TIA diagnosed?

A

Imaging, where TIA is absent on imaging.

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14
Q

What do you look for in imaging for a stroke?

A

4 Ps:
Perfusion
Pipes: Blood vessels to assess atherosclerosis or haemorrhage
Penumbra
Parenchyma: assess early signs of stroke and rule out haemorrhage

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15
Q

What is penumbra?

A

Tissue at risk of necrosis if ischaemia continues.

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16
Q

What are the types of imaging used for stroke?

A

MRI and CT scans which are beneficial because they have a minimal misdiagnosis rate, LOWER in MRIs. Doppler artery ultrasound is used to view the internal carotid artery.

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17
Q

What are the important structural areas in the frontal lobe?

A

Contains Broca’s area in the dominant hemisphere for expressive speech. It is responsible for bladder and bowel control and contralateral movements of the limbs. This area is supplied by the anterior and middle cerebral artery.

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18
Q

What are the important structural areas in the parietal lobe?

A

Contains the post central gurus for the somatosensory cortex, and visual pathways. Parietal lobe on the dominant hemisphere is responsible for calculations while on the non-dominant lobe it is important for body image concept and environmental awareness. It is supplied by the anterior and middle cerebral artery.

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19
Q

What are the important structural areas in the temporal lobe?

A

Contains the auditory cortex and is important for memory and learning. Wernicke’s area is located here for speech comprehension. Olfactory sensation and visual pathways are present here. It is supplied by the middle cerebral artery and anterior choroidal artery.

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20
Q

What are the important structural areas in the occipital lobe?

A

Important for vision, in the calcarine sulcus. It is supplied by the posterior cerebral artery.

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21
Q

What is the importance of the cerebellum?

A

Motor learning, cognitive function, balance and coordination. It receives blood supply from the superior cerebellar artery, anterior inferior cerebellar artery and posterior inferior cerebellar artery.

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22
Q

What are the negative features of a stroke?

A

Weakness and loss of function.

23
Q

What are the positive features of a stroke?

A

Spasticity, abnormal resting posture and co-activation of many muscles in a movement.

24
Q

What are the types of stroke?

A

Ischaemic strokes
Haemorrhaging strokes

25
Q

What is an ischaemic stroke?

A

Caused by an atherosclerotic plaque which ruptures to form an emboli that blocks blood supply to a region of the brain, resulting in necrosis of cells. It is the most common type of stroke and if left untreated, can result in damaged blood vessels rupturing and causing a secondary intracerebral haemorrhage.

26
Q

What is a haemorrhaging stroke?

A

Caused by rupture of a blood vessel in the brain that results in pooling of blood in the skull, placing pressure on the brain tissues and blood vessels which disrupts perfusion. To compensate, the skull may herniate through the foramen magnum, causing brain stem injury. This type of stroke can be secondary to untreated ischaemic stroke.

Haemorrhagic strokes uniquely cause reduced consciousness and headaches.

27
Q

What are the types of haemorrhaging stroke?

A

Intraparenchymal stroke which is contained to brain tissue
E.g Intracerebral and intraventircular

Subarachnoid haemorrhage involving the inner and outer layers of the brain eg Epidural, subdural, subarachnoid stroke

28
Q

What large vessel supplies the brain?

A

Internal carotid artery which gives off the anterior cerebral artery and middle cerebral artery.

29
Q

What are the branching vessels supplying the brain?

A

Anterior cerebral artery
Middle cerebral artery
Posterior cerebral artery

30
Q

What are the perforating vessels of the brain?

A

Branches of larger vessels which provide blood supply to the deeper structures of the brain such as the brain stem, basal ganglia and internal capsule.

31
Q

What is the mechanism of ischaemic stroke?

A

Lack of blood supply to a region of the brain starves it of glucose and oxygen. This causes oxidative stress and mitochondrial dysfunction, causing neuronal cell death. They release DAMP (damage associated molecular patterns) for T cell recruitment and blood vessel breakdown. In the chronic phase, B cells are recruited to create antibodies to destroy that region.

32
Q

What are the vascular causes of ischaemic stroke?

A

Most common is atheromatous plaque
Embolism of cardiac origin
Vasculitis
Drug use can result in arteriosclerosis
Myxoma

33
Q

What is a myxoma?

A

Connective tissue tumour of the mucosa.

34
Q

What is hyaline arteriosclerosis?

A

Hypertension results in a greater hydrostatic pressure. This causes proteins to move into the sub endothelial space of vessel walls, causing stiffening of vessels that reduces blood flow and is prone to rupture.

35
Q

What is a Charcot-Bouchard aneurysm?

A

Micro-aneurysms of the small penetrating vessels of the brain, typically the branches of the middle cerebral artery such as the lenticulostriate branches. This results in rupture and intracerebral haemorrhage.

36
Q

What are the causes of intracerebral haemorrhage?

A

Aneurysm like Charco-Bouchard
Clotting disorders
Severe hypertension
Arterovenous malformation
Cerebral amyloid angiopathy

37
Q

What is Arterovenous malformation?

A

Tangle of blood vessels connecting artery and vein, resulting in disrupted blood flow and oxygen circulation.

38
Q

What is Cerebral amyloid angiopathy?

A

Deposits of amyloid protein which makes vessels fragile and prone to rupture, causing haemorrhagic stroke.

39
Q

How does a carotid artery occlusion present?

A

Affects the anterior and middle cerebral artery branches resulting in:
Consciousness deterioration
Hemiplegia: frontal lobe motor cortex affected
Homonymous hemanopia (same half of vision is affected on each side)
Gaze palsy: frontal lobe eye fields

40
Q

How does an occlusion of the middle cerebral artery present in the dominant hemisphere?

A

Aphasia: difficulty with language and speech due to Broca’s area damage
Aculalia: nonsense speech due to Broca’s area damage
Agraphia: difficulty with writing due to parietal lobe damage

41
Q

How does an occlusion of the middle cerebral artery present in the non-dominant hemisphere?

A

Failure to recognise face: temporal lobe damage
Depressing apraxia: inability to perform tasks and movements

42
Q

How does a Lacunar stroke present?

A

The blood supply to the penetrating arteries for the deep structures of the brain such as basal ganglia, thalamus and internal capsule by perforating arteries is disrupted due to hypertension.

->Dysarthria: difficult speech articulation
-> Ataxic hemiparesis: due to basal ganglia damage
-> Sensory loss
-> Motor loss
-> Mixed motor and sensory loss

43
Q

How does an occlusion to posterior circulation present?

A

Hemianopia: loss of vision in one half
Vertigo: disrupted blood supply to cerebellum
Brain stem syndromes
Sensory loss

44
Q

How are strokes classified?

A

Lacunar infarct
Posterior circulation infarct
Total anterior circulation infarction
Partial anterior circulation infarct

45
Q

How does a Partial anterior circulation infarct present?

A

Higher cortical dysfunction
OR
Motor or sensory deficit affecting only one hand

46
Q

How does a total anterior circulation infarct present?

A

Higher cortical dysfunction
Hemiparesis of one side of body
Homonymous visual field defect

47
Q

What are the predictors of poor stroke recovery?

A

Old age
Incontinence
Visuospatial deficits
Symptomatic co-morbidities

48
Q

What are the goals of stroke treatment?

A

Hyperacute to preserve brain tissue function, restore blood flow and prevent recurrent stroke.

49
Q

How are ischaemic strokes treated?

A

Thrombolytic treatments
Thromboectomy
Aspirin
Statins

50
Q

How are haemorrhagic strokes treated?

A

Craniotomy to relieve pressure
Medication to treat hypertension
Stereotactic aspiration of blood

51
Q

What are the long term issues after a stroke?

A

Haemorrhage and stroke recurrence
Bladdder and bowel incontinence
Reduced cognition and independence
Chronic pain
Communication deficit

52
Q

What are the features of a stroke unit?

A

Provides early hyperacute treatments
Co-ordinated MDT care
Physiological monitoring of heart, rate, oxygen levels

53
Q

What are the causes of fluctuations in patient condition post stroke?

A

Hypotension
Disruption to glucose levels
Arrhythmia
Infection