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IPAP > Pharm 2 Pulm > Flashcards

Pharm 2 Pulm Flashcards

1
Q

Mifepristone

A

Progesterone Antagonist
Pregnancy termination up to day 70
Hyperglycemia in Cusings PTs who can’t have surgery

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2
Q

Estrogen + Cyclic Progesterone

A

Continuous daily E, mimics normal female cycle w/ withdrawal bleed each cycle
E on days 1-25
Medro on days 14-25
No hormone day 26-end of month

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3
Q

Estrogen + Continuous P

What are the 6 PO Estrogen products

A

Daily E and P
No/irregular bleeding for fist 8-12mon

Conjugated x 3
17-B estradiol
Ester
Estro

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4
Q

Estradiol acetate vaginal ring

Transdermal estrogen patches are less likely to cause ?

A

Mod-Sev vasomotor Sxs from menopause and atrophy

HA/N

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5
Q

Norethindrone Acetate

A

2* amenorrhea
Ednometriosis
Abnormal bleeding from abnormal hormones

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6
Q

Megasetrol acetate

A

Appetite stimulant

Metastatic breast CA Tx

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7
Q

Norethindrone

A

Contraception

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8
Q

Levonorgestresl

A

Contraception

Heavy bleeding

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9
Q

Progesterone gel

A

Progesterone deficiency

2* amenorrhea

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10
Q

Micronized Progesterone

A

Endometrial hyperplasiz in post-menopause and receiving conjugated estrogen

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11
Q

Medroxypyrogesterone acetate

A

2* amenorrhea
Abnormal bleeding
Ednometrial hyperplasia prevention in post-meonpause and receiving conjugated estrogen

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12
Q

17-B Estradiol/Norethindrone Acetate

A

Patch form

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13
Q

Bazedoxifene

A

SERM- agonist and antagonist features
Tx of mod-sev Vasomotor Sxs
Prevention of post-menopause osteoporosis

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14
Q

What are the non-hormonal options for menopause

A

Lubes
SERMs- Raloxifene
SSRI
SNRI

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15
Q

What are the 3 herbals/phytoestrogens for menopause

A

Red clover
Soy
Black Cohosh

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16
Q

Ospemifene

A

SERM

Mod/Sev dyspareunia from atrophy due to menopause

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17
Q

Tamoxifen

A

Tx of breast cancer and prevention of CA in high risk women

NOT for osteoporosis

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18
Q

Raloxifene

A

Prevention/Tx of osteoporosis in women w/:
High breast CA risk
Can’t take BisPhosph
50-60y/o and long term concerns of BisPhosph use

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19
Q

Clompiphene

A

Ovulation inducing

Male infertility

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20
Q

Aromatase inhibitors

A

Block P450
Adv Tx of E dependent breast CA
Anastrozole, Letrozole, Exemestane

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21
Q

Fluoxymesterone

A

PO Androgen replacement therapy

Breast CA

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22
Q

Methyltestosterone

A

PO androgen replacement
Breast CA
Post puberty cryptorchidism

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23
Q

Oxandrolone

A

PO anabolic androgen

Promotes weight gain when protein break down is an issue

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24
Q

Oxymethalone

A

PO anabolic androgen

Anemia from deficient RBC production

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25
Q

Danazol

A

PO active androgen derivative for Tx of endometriosis and fibrocystic breast Dz

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26
Q

Anti-Androgen and Androgen antagonists are used for what 4 issues

A

Prostate CA
Endometirosis
Adv Breast CA
BPH

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27
Q

Terazosin/Doxazosin
Alfuzosin
Tamsulosin

A

BPH and HTN
BPH only
A1 selective only for BPH

28
Q

Finasteride

A

5a reductase inhibitor for BPH
Stops progression and reduces size of prostate
Women CANT touch this or semen w/ it

29
Q

PDE5 Inhibitors

A

ED
Pulmonary artery HTN
BPH

-fil the penis

30
Q

Sildenafil

A

PAH/Raynaud’s

Reduce dose for SrCr <30 or Liver Dz

31
Q

Vardenafil

A

ED

Avoid in Liver Dz or Hemodialysis

32
Q

Avanafil

A

ED

Not for CrCl <30 or Liver Dz

33
Q

Tadalafil

A

ED, BPH
Men using if +2/wk
Dec dose for renal dz

34
Q

PDE5 inhibitor interactions

A

Nitrate- deadly HOTN

A-Blockers: -zosin; Sx HOTN

35
Q

FDA approved Androgens for ED

Non-FDA approved drug for ED

A 
Fluoxymesterone
Methyl testosterone
Testosterone enanthate
Testosterone propionate
Alprostadil

Yohimbine HCl

36
Q

Alprostadil

A

ED Tx from spine injury

37
Q

Filbanserin

A

Only drug for female sex dysfunction

38
Q

What are the fertility awareness methods

When should sex be avoided?

A

Temp, Mucus, Calendar (Best is combo of all 3) or

Standard- avoid on days 8-19

39
Q

What is the most common spermicide?

Which implantable contraception device releases both estrogen and progestin?

A

Nonoxynol-9

Vaginal ring

40
Q

Injectable birth control consists of an injection of ?

What was the first birth control pill proven to help w/ heavy monthly periods?

A

Medroxyprogesteron

Natazia

41
Q

Very low dose estrogen = ?mch

Low dose = ?

High dose =?

A

<30mcg

<30-50mg

50mcg or more

42
Q

Sinecatechins 15% ointment

A

Genital/Perianal wart prevention/gene suppression

43
Q

Podofilox/Podophyllum

A

Mortality of gential/perianal wart cells

44
Q

Imiquimod cream

A

Induces cytokines for cutaneous/genital/perianl warts

45
Q

What are the 2 vaccinations for prevention/treatment of warts?

A

Cervarix

Gardasil

46
Q

Physical destruction of wart tissue is most commonly used w/ ?

A 
Keratolytic agents:
Salicyclic acid
Podofilox
Podophyllum
Imiquimod
Duct tape
47
Q

What are the most effective biologic agents against psoriasis?

What can they be combines w/ to improve efficacy?

A

Adalimumab
Infliximab
Etancercept
Ustekinumab

Methotrexate, Acitretin

48
Q

Methotrexate

Reversal agent?

A

Inhibits purine synthesis
Severe Dz of palms, soles, scalp or more than 10% of body surface

Leucovorin

49
Q

Apremilast

A

PDE4 inhibitor

Mod-sev psoriasis in PTs that are candidates for photo/systemic therapy

50
Q

Cyclosporin

What can it be combined w/?

A

Sandimmune- IR capsule
Neoral- microemulsion

Dz refractory/too extensive for topicals

W/ Vit D3 analogs or topical CCS

51
Q

TIMS

A

Atopic dermatitis and chronic inflammatory dz (mild plaque psoriasis)
Alternative to topical CCS
1st line steroid sparing agent for atopic derm/psoriasis of face/flexurs/genitals

52
Q

Calcinuerin inhibitors

A

AKA TIMS
Inhibit T cell activation

Pimecrolimus
Tacrolimus

53
Q

Acitretin

A

Oral retinoid- reduces inflammation by inhibitin neutrophil/monocyte chemotaxis

Monotherapy ror adjunct for severe/refractory or too extensive for topicals
Less risk of organ toxicity than methotrexate of cyclosporines

54
Q

Tazaotene

A

Topical retinoid
Mild plaque psoriasis and acne vulgaris
NOT for genitals or skin fold

55
Q

Vit D3 Analogs

A

Mild psoriasis or combo’d w/ CCS for mod-severe cases

Calcitriol

56
Q

Coal Tar

A

Mild-mod plaque psoriasis but less effective than topicals

For PTs that can’t afford Rx options

57
Q

Topical CCS

A

First line choice for Moderate psoriasis

Combined w/ or alternated w/ Vit D anaologs, Tazarotene or emolients to inc efficacy

58
Q

PO agents for psoriasis treatment

Biologics that can be used?

A

Acitretin
Cyclosporine
Apremilast
Methotrexate

Adalimumab, Infliximab, Etanercept

59
Q

How is psoriasis classified

A

Mild-Mod: <5%, start w/ topical therapies and combine w/ phototherapy

Mod-Sec: 5-10%
Topicals and phototherapy or Systemic Tx

60
Q

Brimondine

A

Selective A2 agonist

Tx of persistent erythema rosacia in 18+y/o

61
Q

Azelaic Acid

A

Rosacia w/ minimal toxicity

Can cause hypopigmentation in dark complex PTs

62
Q

PO Retinoids

A

Only effective agent against severe cystic acne vulgaris
Preg X, test required 2wks prior to use
Must use 2 forms of protection during Tx and for 1mon after Tx

63
Q

Topical retinoids

A

Tretinoin
Used in combo w/ ABX/Benzoyl Peroxide for inflammatory acne
Better tolerated and faster than Tretinoin

64
Q

Tazarotene

A

Best efficacy for psoriasis

Gel form is more irritating that tretinoin

65
Q

What systemic ABX can be used for acne vulgaris

A

Tretracycline/Erythromycin- rarely used
Minocycline/Doxycycline- most common
Sulfamethoxazole/Trimethoprim- in PTs w/ acne resistant to Erythromycin/Tetracyclines but Mino/Doxy are preferred

66
Q

What are the topical ABX used for acne?

A

Clindamycin
Erythromycin
Combo: Clindamycin/Benzoyl Peroxide or Erythromycin/Benzoyl Peroxide

Topical tx for severe acne vulgaris and off label use for rosacia
Benzoyl Peroxide reduces risk of resistence

67
Q

Benzoyl Peroxide

A

Releases oxygen and causes epithelial turnover
For inflamm/non-inflamm acne vulgaris
The MOST effective acne Tx
Enhanced when combined w/ topical erythromycin

IPAP (212 decks)

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