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Pharm 2 Pulm Flashcards

1
Q

Mifepristone

A

Progesterone Antagonist
Pregnancy termination up to day 70
Hyperglycemia in Cusings PTs who can’t have surgery

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2
Q

Estrogen + Cyclic Progesterone

A

Continuous daily E, mimics normal female cycle w/ withdrawal bleed each cycle
E on days 1-25
Medro on days 14-25
No hormone day 26-end of month

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3
Q

Estrogen + Continuous P

What are the 6 PO Estrogen products

A

Daily E and P
No/irregular bleeding for fist 8-12mon

Conjugated x 3
17-B estradiol
Ester
Estro

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4
Q

Estradiol acetate vaginal ring

Transdermal estrogen patches are less likely to cause ?

A

Mod-Sev vasomotor Sxs from menopause and atrophy

HA/N

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5
Q

Norethindrone Acetate

A

2* amenorrhea
Ednometriosis
Abnormal bleeding from abnormal hormones

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6
Q

Megasetrol acetate

A

Appetite stimulant

Metastatic breast CA Tx

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7
Q

Norethindrone

A

Contraception

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8
Q

Levonorgestresl

A

Contraception

Heavy bleeding

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9
Q

Progesterone gel

A

Progesterone deficiency

2* amenorrhea

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10
Q

Micronized Progesterone

A

Endometrial hyperplasiz in post-menopause and receiving conjugated estrogen

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11
Q

Medroxypyrogesterone acetate

A

2* amenorrhea
Abnormal bleeding
Ednometrial hyperplasia prevention in post-meonpause and receiving conjugated estrogen

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12
Q

17-B Estradiol/Norethindrone Acetate

A

Patch form

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13
Q

Bazedoxifene

A

SERM- agonist and antagonist features
Tx of mod-sev Vasomotor Sxs
Prevention of post-menopause osteoporosis

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14
Q

What are the non-hormonal options for menopause

A

Lubes
SERMs- Raloxifene
SSRI
SNRI

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15
Q

What are the 3 herbals/phytoestrogens for menopause

A

Red clover
Soy
Black Cohosh

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16
Q

Ospemifene

A

SERM

Mod/Sev dyspareunia from atrophy due to menopause

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17
Q

Tamoxifen

A

Tx of breast cancer and prevention of CA in high risk women

NOT for osteoporosis

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18
Q

Raloxifene

A

Prevention/Tx of osteoporosis in women w/:
High breast CA risk
Can’t take BisPhosph
50-60y/o and long term concerns of BisPhosph use

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19
Q

Clompiphene

A

Ovulation inducing

Male infertility

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20
Q

Aromatase inhibitors

A

Block P450
Adv Tx of E dependent breast CA
Anastrozole, Letrozole, Exemestane

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21
Q

Fluoxymesterone

A

PO Androgen replacement therapy

Breast CA

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22
Q

Methyltestosterone

A

PO androgen replacement
Breast CA
Post puberty cryptorchidism

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23
Q

Oxandrolone

A

PO anabolic androgen

Promotes weight gain when protein break down is an issue

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24
Q

Oxymethalone

A

PO anabolic androgen

Anemia from deficient RBC production

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25
Danazol
PO active androgen derivative for Tx of endometriosis and fibrocystic breast Dz
26
Anti-Androgen and Androgen antagonists are used for what 4 issues
Prostate CA Endometirosis Adv Breast CA BPH
27
Terazosin/Doxazosin Alfuzosin Tamsulosin
BPH and HTN BPH only A1 selective only for BPH
28
Finasteride
5a reductase inhibitor for BPH Stops progression and reduces size of prostate Women CANT touch this or semen w/ it
29
PDE5 Inhibitors
ED Pulmonary artery HTN BPH -fil the penis
30
Sildenafil
PAH/Raynaud's | Reduce dose for SrCr <30 or Liver Dz
31
Vardenafil
ED | Avoid in Liver Dz or Hemodialysis
32
Avanafil
ED | Not for CrCl <30 or Liver Dz
33
Tadalafil
ED, BPH Men using if +2/wk Dec dose for renal dz
34
PDE5 inhibitor interactions
Nitrate- deadly HOTN | A-Blockers: -zosin; Sx HOTN
35
FDA approved Androgens for ED Non-FDA approved drug for ED
``` Fluoxymesterone Methyl testosterone Testosterone enanthate Testosterone propionate Alprostadil ``` Yohimbine HCl
36
Alprostadil
ED Tx from spine injury
37
Filbanserin
Only drug for female sex dysfunction
38
What are the fertility awareness methods When should sex be avoided?
Temp, Mucus, Calendar (Best is combo of all 3) or | Standard- avoid on days 8-19
39
What is the most common spermicide? Which implantable contraception device releases both estrogen and progestin?
Nonoxynol-9 Vaginal ring
40
Injectable birth control consists of an injection of ? What was the first birth control pill proven to help w/ heavy monthly periods?
Medroxyprogesteron Natazia
41
Very low dose estrogen = ?mch Low dose = ? High dose =?
<30mcg <30-50mg 50mcg or more
42
Sinecatechins 15% ointment
Genital/Perianal wart prevention/gene suppression
43
Podofilox/Podophyllum
Mortality of gential/perianal wart cells
44
Imiquimod cream
Induces cytokines for cutaneous/genital/perianl warts
45
What are the 2 vaccinations for prevention/treatment of warts?
Cervarix | Gardasil
46
Physical destruction of wart tissue is most commonly used w/ ?
``` Keratolytic agents: Salicyclic acid Podofilox Podophyllum Imiquimod Duct tape ```
47
What are the most effective biologic agents against psoriasis? What can they be combines w/ to improve efficacy?
Adalimumab Infliximab Etancercept Ustekinumab Methotrexate, Acitretin
48
Methotrexate Reversal agent?
Inhibits purine synthesis Severe Dz of palms, soles, scalp or more than 10% of body surface Leucovorin
49
Apremilast
PDE4 inhibitor | Mod-sev psoriasis in PTs that are candidates for photo/systemic therapy
50
Cyclosporin What can it be combined w/?
Sandimmune- IR capsule Neoral- microemulsion Dz refractory/too extensive for topicals W/ Vit D3 analogs or topical CCS
51
TIMS
Atopic dermatitis and chronic inflammatory dz (mild plaque psoriasis) Alternative to topical CCS 1st line steroid sparing agent for atopic derm/psoriasis of face/flexurs/genitals
52
Calcinuerin inhibitors
AKA TIMS Inhibit T cell activation Pimecrolimus Tacrolimus
53
Acitretin
Oral retinoid- reduces inflammation by inhibitin neutrophil/monocyte chemotaxis Monotherapy ror adjunct for severe/refractory or too extensive for topicals Less risk of organ toxicity than methotrexate of cyclosporines
54
Tazaotene
Topical retinoid Mild plaque psoriasis and acne vulgaris NOT for genitals or skin fold
55
Vit D3 Analogs
Mild psoriasis or combo'd w/ CCS for mod-severe cases Calcitriol
56
Coal Tar
Mild-mod plaque psoriasis but less effective than topicals | For PTs that can't afford Rx options
57
Topical CCS
First line choice for Moderate psoriasis Combined w/ or alternated w/ Vit D anaologs, Tazarotene or emolients to inc efficacy
58
PO agents for psoriasis treatment Biologics that can be used?
Acitretin Cyclosporine Apremilast Methotrexate Adalimumab, Infliximab, Etanercept
59
How is psoriasis classified
Mild-Mod: <5%, start w/ topical therapies and combine w/ phototherapy Mod-Sec: 5-10% Topicals and phototherapy or Systemic Tx
60
Brimondine
Selective A2 agonist Tx of persistent erythema rosacia in 18+y/o
61
Azelaic Acid
Rosacia w/ minimal toxicity | Can cause hypopigmentation in dark complex PTs
62
PO Retinoids
Only effective agent against severe cystic acne vulgaris Preg X, test required 2wks prior to use Must use 2 forms of protection during Tx and for 1mon after Tx
63
Topical retinoids
Tretinoin Used in combo w/ ABX/Benzoyl Peroxide for inflammatory acne Better tolerated and faster than Tretinoin
64
Tazarotene
Best efficacy for psoriasis | Gel form is more irritating that tretinoin
65
What systemic ABX can be used for acne vulgaris
Tretracycline/Erythromycin- rarely used Minocycline/Doxycycline- most common Sulfamethoxazole/Trimethoprim- in PTs w/ acne resistant to Erythromycin/Tetracyclines but Mino/Doxy are preferred
66
What are the topical ABX used for acne?
Clindamycin Erythromycin Combo: Clindamycin/Benzoyl Peroxide or Erythromycin/Benzoyl Peroxide Topical tx for severe acne vulgaris and off label use for rosacia Benzoyl Peroxide reduces risk of resistence
67
Benzoyl Peroxide
Releases oxygen and causes epithelial turnover For inflamm/non-inflamm acne vulgaris The MOST effective acne Tx Enhanced when combined w/ topical erythromycin

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