OBGYN Block 3 Flashcards
What is the MC form of contraception in the world?
What is the MC form used in the US?
IUD
PO CHCs
What two forms of contraception are not recommended for PTs w/ HTN?
What form is not recommended for PTs w/ migraine and aura?
Depo, CHC
CHCs
What are the 5 tiers of contraception?
What tier would PTs w/ HIV want to avoid?
1: implant, IUD, Sterilization
2: Ring Injection Pill Patch
3: Barrier Behavior
4: Spermicide Sponge Cream/Jelly/Foam
No: Plan-B Abortion
4: spermicide
What are the criteria for being reasonably certain PT is not pregnant?
<7d after start of normal menses
No intercourse since start of last normal menses
Correct/consistent contraception use
<7 days post-abortion
<4wks post-partum
Breastfeeding >85%, amenorrheic and <6mon post-partum
What form of contraception can HIV PTs use?
Breast feeding PTs should not be given COCs if they are post-partum for how long?
All forms, caution w/ spermicide
<1mon PP, no COCs
Use POPs
Tier 1 contraceptives are AKA ?
What are the indications for a PT to receive an IUD?
Long Acting Reversible Contraception (LARCs)
Hormone avoidance Adolescent Nulliparous Dysfunctional bleeds- Levon Stable relationship
What are the 4 brands w/ length of use?
What is their MOA?
? term encompasses the brand names?
Mirena- 5yrs
Liletta- 3yrs
Kyleena- 5yrs
Skyla- 3yrs
Prevention of fertilization
Levonorgestrel
Cu IUD
Endometrial inflammation
No impact on ovulation
Dec sperm/egg viability, motility
Anti-blastocyst action
Good for:
Breast Ca
Anti-phospholipid Ab syndrome
Thromboembolic dz
What are the s/e of Cu IUD?
How long does it take for fertility to return upon d/c of this form?
Menstrual changes- first 3mon
Possible dysmenorrhea or heavier cycles, Tx w/ NSAIDs
Immediately
Levonorgestrel IUDs are used for how long?
The long term progestin release of this form leads to what 3 results?
Used up to 5yrs
Dec sperm motility
Inconsistent ovulation inhibition
Endometrial atrophy prevents implantation
What are the s/e of using Levonorgestrel IUDs?
What is a benefit of using these?
Spot/irregular bleeds x 6mon
1mon post-insertion- device related infections
Improves dysmenorrhea
What do PTs have to do if Levonorgestrel device is placed >7d after menses started?
When do they need to f/u w/ PCM?
What is done if strings can’t be visualized?
Use back up x 7d
6wks
Verify non-pregnancy
Cytology brush to entangle strings and pull into vaginal vault
No strings= US
What are the S/Sxs of PT that has an IUD that has moved into lower uterine segment?
When are IUD expulsions more common?
Continued/new pelvic pain or cramps
First month
Placement <6wks post partum
<25y/o
If PT becomes pregnant w/ IUD in place, there is a higher change of ?
If PT has 2nd trimester miscarriage w/ IUD in place there is a higher likelihood for ?
Ectopic pregnancy
Infection
MOA of Etonogestrel rod implant
How long is this good for?
This form can’t be seen on ? imaging and is not affected by ? PT Hx
Inhibits LH, endometrial atrophy, thickens mucus=
Inhibits ovulation*, implantation and sperm motility
3yrs
Radiopaque
Obesity
What is the MC adverse effect of all progestin-only contraceptives?
What are the two absolute c/is for use?
Irregular/heavy uterine bleeds
Current breast Ca
Pregnancy
Nexplanons are placed w/in ? days of menses onset
What if this time limit is not met and device is still inserted?
5days
Back up x 7d
How long does it take for fertility to return after removal of Nexplanon?
When is Nexplanon use more preferred?
6wks, up to 1yr
Post-partum/abortion
Lactating
How often are Depo shots given?
What is the MOA
150mg q3mon IM- delt/glut
Same as progestin only:
Inhibits LH, endometrial atrophy, thickens mucus=
Inhibits ovulation, implantation and sperm motility
What is the non-contraceptive benefit of Depo?
What are the c/is?
What is the absolute c/i?
Improves dys/menorrhea, endometriosis pain
Dec risk hyperplasia/cancer
Inc risk functional cysts
Recent breast Ca
Progesterone + Ca
Prior ectopic pregnancy
Pregnant
Current breast Ca
What are the adverse effects of Depo use?
How does this effect post-partum status?
Bone loss, reversible (supp E secretion) Irregular bleeding Weight gain Amenorrhea Severe HTN Prolong anovulation/amenses after d/c
No impairment on milk production
What are POPs AKA and what is the only formula?
Norethindrone 0.35mg
Mini-pill
What is the MOA of POPs?
What is a non-contraceptive MOA?
Inhibits LH, endometrial atrophy, thickens mucus=
Inhibits ovulation, implantation and sperm motility
Unreliable ovulation inhibition
POPs are mostly used in ? PT population?
What PT education piece has to go with this Rx?
Breast feeding
Estrogen c/i PTs
Same 4hr window every day of use back up x 48hrs
What are the absolute c/is for Rx POPs?
What are the three forms of CHCs?
Breast Ca
Pregnancy
Ring Patch Pill (CoC)
What is the MOA of CHCs?
Suppress LH/FSH release to inhibit ovulation
P: inhibits LH= suppresses ovulation, dec sperm motility, inhibits implantation
E: inhibits FSH release to suppress ovulation, cycle control to prevent bleeding
CHCs contain ? max amount of estrogen?
Why is this?
Progestin component of CHCs have been modified to provide ? benefits
<35mcg
Dec risk for thromboembolus
Dec androgenic effect (weight acne hair lipids)
When would a 4th Generation progestin like Yaz be preferred?
What is the adverse effect of Yaz?
PTs w/ PMS- breast tenderness,
Inc Na/Water excretion to dec bloat
HyperK+
What are the two types of CHC hormone levels
How does the generation of CHC and amount of progestin differ?
How many days are spent hormone free on this regime?
Monophasic- same amount/pill
Multiphasic- estrogen varies 10-50mcg
Later generation= less androgenic effect, inc PE/VT/MI risk
4-7days
What are the benefits of PO CHCs?
What are the risks?
No risk Ca
Efficacy not impacted by obesity
Dec bleeding, acne, hair
Inc clot risk
What are the non-contraceptive benefits of PO CHCs?
How long does it take for fertility to return?
Dec heavy bleeding/androgen
Improves PMDD Sxs
Improves cycle irregularities
1-2wks for return
6-12mon to regular
What are the PO CHC initiation methods?
1st day: day 1 of menses, no back up needed
Sunday: first Sunday after menses starts, back up x 7d
No weekend withdrawal/bleed
Quick: start day Rx, back up x 7d
What chemical in PO CHCs helps improve PMDD Sxs?
Drospirenone
What are the absolute c/is to CHCs?
CLIMBED UP PAD TV CVA Liver tumor Ischemic heart dz Migraine w/ aura Breast Ca Estrogen dependent tumore Decompensated cirrhosis
UnDx genital bleeding
Pregnancy
Peripartum cardiomyopathy
>35y/o and >15 smokes/day
DM x 20yrs
Thrombogenic states: <21d post partum, DVT/PE, SLE
Vascular dz/uncontrolled HTN
What are the complications that can arise from CHC use?
Benign hepatic tumor Cholelithiasis Post-pill amenorrhea HTN Mood swings Thromboembolism Stroke
What are the s/es in order of prevalence PT experience upon d/c of PO contraceptives?
Irregular bleeds Nausea Weight gain Mood swing Breast tenderness HA
What are the 3 forms of continuous PO OCP
EE 30mcg + Levon .15mg= 84/7, 4 menses/year
EE 10mcg
Levon 90mcg/EE 20mcg
Where is the patch placed on the body?
What is the down side of patch CHC use?
Weekly on butt arm abdomen or torso x 3wks
Not on breast
> 90kg dec efficacy
What is done if patch placement is delayed in 1st wk?
What is done if patch placement is delays in 2nd or 3rd week?
What if the patch becomes detached?
Reapply, back up x7d
<2d, no back up
>2d, back up x 7d
<24hrs- replace same patch, no back up
>24hrs- new patch, back up x 7d
What are the advantages of transdermal CHCs?
What are the disadvantages?
Avoidance of first pass
Constant plasma hormone
Inc compliance
Immediate fertility return
Inc DCT
Skin rash
How long are these used for?
Why are these poor choices for deployments?
3wks in, 1wk out
Refrigeration requirement
Annovera doesn’t require this
When is back up birth control needed w/ CHC rings?
What is done if the ring falls out?
Day 1 start- none
Day 2-5: 7d back up
Reinsert <3hrs, none
Out for >3hrs, back up x 7d
What is a non-contraceptive benefit to CHC rings?
How long does it take for fertility to return?
Lighter/shorter cycles after 6mon
Rapidly
What are the steps if PT misses one pill but is <48hrs total?
Take late/missed pill ASAP
Continue taking remaining pills on schedule
No back up needed
What are the steps taken if PT misses one pill but is >48hrs total?
Take most recent missed, toss remaining missed
Continue taking remaining pills on schedule
Use back up
If pills were missed on days 15-21: finish hormone pack, start new pack next day
PO COCs decrease the chances/prevalence of ? two cancers?
What is the only physical assessment required prior to starting CHCs?
Ovarian
Endometrial
BP
What are the facts about diaphragms?
How long do cervical caps need to remain in place and what is it AKA?
Require fitting 6hrs prior/post intercourse Inc UTI risk Inc efficacy w/ spermicide Dec risk of STDs
48hrs, higher failure rate
Sailor cap
What are the 4 fertility awareness methods?
Standard days- avoid sex day 8-19; must have cycles q 26-32d
Temp rhythm- every morning, 0.4-0.8* inc x 2d
Cervical mucus- high E= prep for ovulation/implant, inc mucus
High P= white/thick mucus to prevent sperm entrance
Symptothermal methods- combo mucus and body temp; reqs 12-17d of abstinence/mon
What are the two cervical mucus methods?
Two day- safe if no mucus on/day prior to intercourse
Billings- abstain from menses to 4d after identification of watery/slippery mucus
What are the 3 forms of emergency contraception?
PO hormones <72hrs
P only: Levon 1.5mg
COC: EE + Levon 100mcg (Yuzpe regime)
Progesterone antagonist <120hrs (most efficient PO regimen)
Ulipristal 30mg
Cu IUD <120hrs (most effective)
Facts of Lactational Amenorrhea
What form of contraception can be used while breast feeding?
Unlikely ovulation 10wks post-delivery
Switch to back up after 6mon
Must feed >85% of time
POP/mini
When is post-partum contraception recommended to begin?
Do not give E/P contraceptives w/in ? after delivery
Prior to first menses
4wks d/t inc venous thrombus risk
How long after vasectomy is male considered ‘safe’?
Why is this form of sterilization preferred?
3mon/20 ejaculations
Requires confirmation
Safer/more efficacious than tube ligation
What meds are used for elective pregnancy termination and they’re taken on ? day
What are the 3 surgical procedures?
Mifepristone/Methotrexate- 1
Misoprostol- 3
Vacuum: 5-6wks
DnC: 6-13wks
Induction: >16wks
Ovulation can return as quickly as ? wks after pregnancy terminations?
Define Fecundity
Define Fecundability
2wks
Probability of achieving live birth in single menstrual cycle
Ability to conceive; probability of achieving pregnancy per month of exposure (20%/cycle, 50% in 3mon, 85%/year)
Female fertility if reduced by half during what ages?
What is the ‘conception window’?
What can be done to maximize this window?
37-45y/o
5 days prior to day of ovulation
Daily intercourse
Qod 10 days around ovulation
What is the criteria to begin infertility work ups?
How does this change if female is of advanced age?
Failure to conceive w/in 12mon w/ regular coitus and w/out contraception
> 35y/o= 6mon
COCs can prevent ovulation from returning x ?mon
Dep can prevent ovulation from returning x ?mon
12mon
24mon
What are the 5 etiologies of infertility in order of prevalence?
What has more impact on inability to conceive, under/over weight?
Ovulatory Male factors Tubal/uterine Unexplained Other
Under, <19
How does smoking induce infertility?
How does alcohol induce infertility?
Vascular/endothelial dysfunction do to reduced nitric oxide availability
Dec female fertility/sperm count
Inc male sex dysfunction
How does marijuana/coke induce infertility?
Infertility eval consists of ? and encompasses ? triad
M: suppresses HPG axis
C: impairs speratogenesis
Hx/PE both partners
Ovulation
Norm F reproductive tract
Norm semen characteristics
Semen analysis reqs ? days of abstinence?
How many samples are needed?
2 days
2 samples 3wks apart
What presenting female PE indicated ovulation is occurring?
Define Mittelschmerz
How does this present
Menses q25-35d w/ 3-7d duration
Ovulation pain: unilateral mid-cycle pelvic pain w/ ovulation
Breast tenderness
Acne
Mood swings
Food cravings
What are the luteal phase/PMS Sxs?
At home ovulation kits are made to detect ?
Breast heaviness
Dec vaginal secretion
Abdominal bloating
Mild peripheral edema
LH surge prior to fertility window
? test is a more direct and earlier detection of ovulation?
PTs w/ irregular menstrual cycles have ? labs drawn for anovulation work ups?
Serum progesterone
>4-6ng during mid-luteal phase
TSH/FSH
Testosterone
Prolactin
DHEA-5
Female PT w/ STI Hx may indicate ? anatomic reason for infertility?
What imaging studies are used for assessing tubal patency?
Tubal for STI/PID issues
HSG
SIS
Laparoscopy
What imaging studies are used for assessing uterine cavity?
What imaging studies are used for assessing ovaries?
All but laparoscopy
All but HSG and Hysteroscopy
What imaging studies are used for assessing for endometriosis/PAD?
What imaging studies are used for assessing for developmental defects?
HSG
Laparoscopy
All