IMC-RR Flashcards

1
Q

? is the strongest predisposing factor to asthma

What is the triad

What test results can mean Dx

A

Atopy

Asthma
Allergy
Eczema

Obstructive pattern w/ FEV1 improved by 12% one second after albuterol administration

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2
Q

? is the best objective test to determine asthma exacerbation severity

How is this Tx in step wise manner

A

Peak expiratory flow rate

Acute: Rescue SABA,
Inhaled steroid

Mod:
LABA (salmeterol) or increased ICS dose

Sev: 
High ICS dose w/ B-agonist, 
SABA- rescue
LABA- long term management
PO steroids
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3
Q

? is used for first line maintenance therapy Tx for asthma

What medications target mast cell degranulation in asthmatics

What are the 5 etiology groups for P-HTN

A

ICS

Mast Cell Stabilizer:
Cromolyn sodium
Nedocromil

1: Pulm artery HTN
2: d/t left HDz
3: lung dz/hypoxemia
4: embolic P-HTN
5: unclear mechanism

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4
Q

P-HTN is defined as ?

What is the first step for Dx

How is a Dx confirmed

A

Mean pulmonary arterial pressure >25mmHg

Echo

R heart cath

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5
Q

How is Primary P-HTN Tx

What is heard on exam

Define Ortner’s Syndrome

A

CCBs
Inhaled PPD inhibitors
Prostacycins
Endothelin receptor antagonist

Ejection click after S1
Loud, narrow split S2

Compressed recurrent laryngeal d/t dilated pulm artery

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6
Q

When is asterixis not observed in hepatic encephalopathy

What meds can be used to first and second lower ammonia levels

How long can first line therapy be used before combo therapy is indicated

A

Grade 4: comatose Pts

Lactulose- first line w/ goal fo 2-3 movements/day
Rifaximin- second line

48hrs, add Rifaximin for combo therapy

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7
Q

What are the 2MC causes of cirrhosis in US

? is the MC enzyme based RBC abnormality

How is this MC inherited

A

Alcohol
Hep C

G6PD

X-linked, rarely affects females

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8
Q

How is G6PD Dx

What results would be seen during an exacerbation

How are acute exacerbations Tx

A

Peripheral smear w/ bite/blister cells and Heinz bodies

Reticulocytes
Inc indirect bilirubin

D/c offender
Aggressive fluid therapy

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9
Q

Define Heinz Bodies

Initial therapy for asthma attacks include ?

What is used for attacks resistant to initial therapy

What is the next step for continued Sxs

A

Clusters of denatured Hgb chains attached to RBC membranes

O2
Inhaled bronchodilators
Anticholinergic- allbuterol and ipratropium

Systemic CCS

IV Mg Sulfate

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10
Q

Tx acronym for asthma exacerbations

? reading on peak flow is considered a severe asthma attack

A
BIOMES:
B-agonist
Ipratropium
O2
Mg sulfate
Epi/Terbutaline
Steroids

<50%

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11
Q

SA node natural pace range
AV node natural pace range

? EKG finding signals a sinus origin of bradycardia

What two issues must be r/o when Pts present w/ bradycardia

A

60-100
40-60

Pos deflection 1, 2, aVL
Neg deflection aVR

Hemodynamic
Acute MI

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12
Q

How does atropine help Tx bradycardia

What is the max dose used

Define Cafe Coronary Syndrome

A

Competitively inhibits acetylcholine from vagus nerve in the AV node

3mg or 0.04mg/kg

Asphyxiation d/t airway obstruction from poorly chewed food

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13
Q

What two drugs can be used for Tx of idiopathic pulmonary fibrosis

? is the only definitive Tx

? is the MCC of digital clubbing

A

Nintedanib
Pirfenidone

Transplant

Lung Ca

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14
Q

Define Kussmaul Sign

? BNP levels suggest restrictive cardiomyopathy

Since Restrictive Cardiomyopathy can present similar to constrictive pericarditis, how is it differentiated

A

Inc JVD w/ inspiration seen in restrictive cardiomyopathy

> 400pg/mL

RC- S3
CP- pericardial knock

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15
Q

Normal sinus rhythms will have ? type of P-wave shapes on EKG

Define Boerhaave Syndrome

What is an abnormal/rare PE finding

A

Upright in Lead 2
Biphasic V1

Transmural perf d/t inc esophageal and negative chest pressures

Hematemesis

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16
Q

What is the MC location for Boerhaaves to develop

What is the name of the Triad for this presentation

How are varicose veins defined by size

A

Left posterolateral aspect of distal esophagus

Mackler- vomitting, lower thoracic pain, subcutaneous emphysema

> 3mm diameter

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17
Q

How are varicose veins Tx

What are the 4 categories for varicose classifications

What meds can be used to help heal stasis ulcers induced by varicose veins

A

Compression/lifestyle x 3mon
Sclerotherapy
Ablation- deep > superficial

Clinical
Etiologic
Anatomic
Pathophysiological

Rheologic-
ASA, Pentoxifylline

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18
Q

Time frames for HTN Emergency Tx

Define Masked HTN

? is the MC PE finding in Pts w/ constrictive pericarditis

A

Goal <180/120 in first hour-
Dec x 25-30% in first 2hrs

Goal <160/110 in next 23hrs-
Dec 5-15% in 23hrs

Normally elevated but appears normal at office appointments

Inc JVP

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19
Q

What two conditions cause Kussmaul Sign

? is the MC type of pre-Ca cell type seen in PTs w/ Barretts

Barrett’s can progress into ? type of Ca

A

Constrictive Pericarditis
Severe TV Dz

Specialized intestinal epithelium- only type w/ clear malignant potential

Adeno

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20
Q

What Rx combo can prevent Barretts progression into Adenocarcioma

? underlying Dx is protective against Barrett’s progression

Native valve endocarditis is caused by ? while prosthetic/IVDA infections are caused by ?

A

ASA+Statin

H Pylori

Native: Strep viridians
Prosthetic: Staph epidermis
IVD: Staph aureus

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21
Q

? is the MC neurological presentation of endocarditis

What is needed per Duke’s for Dx

A

Focal neuro deficits d/t vegetation breaking off of valves

Two major
One major, 3 minor
Five minor

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22
Q

Duke Major criteria

Duke Minor criteria

? is the imaging modality of choice

A

Two + blood cultures w/ +Echo vegetation
New valve regurgitation

Vascular phenomenon
Immune phenomenon
Prev heart Dx/IVDA
\+Culture atypical for endocarditis
Fever

TEE

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23
Q

? is the MC cause of traumatic aortic dissections

? is the biggest RF for a traumatic and atraumatic dissection

? part of the aorta is most likely to tear

A

MVC

Trauma: rapid deceleration
Atrauma: HTN

Isthmus- distal to left subclavian

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24
Q

Aortic dissection present w/ murmurs similar to ?

How are these Pts assessed w/ imaging pending hemodynamic status

? drugs can and can’t be used to lower HTN in cocaine use

A

Aortic regurgitation

Stable: CT
Unstable: bedside Echo

Yes: Esmolol, Labetolol
No: non-selective BBs

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25
Q

3 etiologies for Secondary Pneumothorax

Why do these occur

How are these Tx

A

Trauma
Infection
Malignancy

Apical blebs rupture

Unstable: Needle-D, thoracostomy
Stable: observe
Secondary: thoracostomy

26
Q

Define Pulsul Parvus et Tardus

What are the 4 types of drug allergy eruptions

A

Delayed carotid artery pulse w/ plateaued peak and decreased amplitude during Aortic Stenosis

1: anaphylactic, IgE mediated mast cell degranulation
2: cytotoxic, IgG/IgM activate complement
3: immune, IgG/IgM activate complement
4: delayed cell mediated, activated T-cells against surface Ags

27
Q

Examples of Class 1 hypersensitivity reactions

Examples of Class 2 hypersensitivity reactions

Examples of Class 3 hypersensitivity reactions

Examples of Class 4 hypersensitivity reactions

A

Anaphylaxis
Urticaria
Angioedema

Autoimmune hemolytic anemia
Goodpasture
Erythroblastalis fetalis

PostStrep nephritis
Lupus
Serum sickness

PPD
Rejection, transplant
Dermatitis, contact

28
Q

IgE mediated reactions cause ? two cells to release ? substances

What are the 4 MC etiologies for drug mediated hypersensitivity reactions

Respiratory Distress Syndrome is AKA ?

A

Mast cell, Basophils-
Histamine
Leukotriene
Prostaglandins

B-lactam ABX
ASA
NSAIDs
Sulfas

Hyaline Membrane Dz

29
Q

Define Hyaline Membrane Dz

What cells are responsible for making what is lacking in this condition

When are these cells normally seen in gestation

A

D/o of decreased surfactant

Type 2 pneumocytes

20wks,
Maxed at 34-36wks

30
Q

? is used for a screening tool for RDS

What CXR finding is seen

How is this prevented and how is it Tx

A

Phosphatidylglycerol via amniotic fluid test

Ground glass w/ visible air in bronchograms

Prevent:
Betameth/Dexamethasone 48hrs prior to delivery
Tx:
Intratracheal surfactant
O2/Vent
31
Q

Infants Tx for RSD w/ prolonged ventilation are at risk for ?

What causes diverticulosis to develop

? type of liver Ca accounts for >85% of liver Ca

A

Bronchopulmonary dysplasia

Weak point in colon from inc pressure where vasa recta penetrate muscular layer

Hepatocellular carcinoma

32
Q

? is the MCC of painless lower GI bleeds

What is the biggest RF for hepatocellular Ca

? lab result is elevated in 90% of Pts

A

LLQ Diverticulosis

Cirrhosis

Gamma carboxy prothrombin

33
Q

? is the prognosis predtor for Pts w/ hepatocellular Ca

? is the MC malignant liver tumor in infant/children

How does P Jiroveci appear on CXR

A

AFP levels at Dx:
>200 at Dx or,
Inc >15ng/mon= poor

Hepatoblastoma

Difuse interstitial/alveolar infiltrate (bat wing)

34
Q

How is P Jiroveci Tx if Pts has severe sulfa allergy

? is the serological hallmark of an active Hep B infection

A

Clindamycin-primaquine or,
Trimethoprim-dapson

HBsAg

35
Q

Use of HBsAG

Use of Anti-HBs

A

Screen/Detect/Dx acute/chronic infection
First indicator acute HBV
IDs chronic infection/HBV carrier

Detects previous exposure
Proves vaccination Hx/need
Presence= immune

36
Q

Use of Anti-HBc

Use of Anti-HBc IgM

A

Helps detect acute/chronic HBV infection
IgM- produced first
IgG- produced later and lasts for life

Detects acute infections

37
Q

Use of HBeAG

Use of Anti-HBe

A

Marker of infectivity
Screens Tx efficacy

Monitoring acute infection

38
Q

What are the two MC s/e of Verapamil use

How is TB screened and Dx

How are HIV negative Pts Tx

A

Gingival hyperplasia
Constipation

Screen: PPD
Dx: acid-fast sputum stain

RIPE x 2mon w/ B6 (pyridoxine)
RI x 4mon

39
Q

? is the 2nd MC cause of infectious death in adults world wide

What types of tumors are lung carcinoma tumors

What is the MC location of carcinoid tumor

A

TB

Neuroendocrine- secrete serotonin

GI

40
Q

? is the MC lung neoplasm of children

How does this present

What doe these look like on CXR

A

Lung carcinoid tumor

Wheeze
Hemoptysis
Recurrent pneuonia

Small, round apacities w/out cavitation

41
Q

How are lung carcinoids Dx w/ imaging

? method can Dx and detect mets

How are these Tx

A

CT then lung biopsy

Somatostatin receptor scintograpy

Resection

42
Q

? hyper secreted hormone is associated w/ lung carcinoid tumor

Hypertriglyceridemia is defined as ?

When is medical intervention indicated and what is used

A

ACTH leading to Cushing’s Syndrome

Fasting TG >150mg
MIld: 150-400
Mod: 500-886
Sev: >886

> 886:
Fibrates: Gemfibrozil, Fenofibrate
Nicotinic acid
Fish oil

43
Q

? 4 classes of meds lower TG levels and by ? much

? is the MC manifestation of TB

A

Fibrates: 30-50%
Niacin: 30-50%
Omega-3: 30-50%
Lova/Atorvastatin: 20-40%

Pulmonary tB

44
Q

What makes a PPD positive at 5mm

What makes a PPD positive at 10mm

? size is positive if Pt has no RFs

A

Active HIV
CXR w/ TB granuloma
Organ transplant
Close contact w/ TB

Homeless
IVDA
Medical employees
Endemic area immigrant
<4y/o

15mm

45
Q

How is latent TB Tx

? type of reaction is the PPD test

? TB tx needs to be used w/ supplemental nutrition

A

Rifampin x 4mon
INH x 9mon

Type 4- mediated by T-lymphocytes

INH w/ B6 pyridoxine to prevent peripheral neuropathy

46
Q

Define Cheyne-Stokes respiration

What causes this respiratory pattern

How is this type of breathing Dx

A

Apnea followed by faster/deeper breathing followed by decreasing depth/frequency until apena again

Delayed arterial CO2 detection
Delayed ventilation

Sleep study, polysomnogram

47
Q

Cheyne Stokes breathing can be seen during ? five times

? gas is responsible for controlling respiration

C Diff is MCC by ? ABX

A
Prematurity
Altitude acclimation
Neuro dz
CHF
End of life

CO2

Flqn- Cipro
Clindamycin
Cephalosporin
PCNs

48
Q

? colonoscopy finding suggests C Diff

What three ABX are used for Tx

What are the 3 RFs for C Diff

A

Pseudomembranous colitis

PO Vanc
PO Fidaxomicin
Metronidazole

ABX
Hospitalization
Inc age

49
Q

? is the cardinal Sx of bronchitis

? PE finding is rare and it’s presence should change the Dx

How is this Tx

A

Cough x 5days

Fever- pneumonia, flu

Dextromethophan
Guaifanesin
Codein
Wheeze/Pulm Dz- albuterol

50
Q

? is the first line ABX therapy for pertussis

? lab result indicated a perforated appendix

? ABX is used pre-operatively

A

MacrolideL ACE-mycin

Elevated total serum bilirubin

2g Cefoxitin
PCN allergy: Clinda w/ Cipro or Levo

51
Q

+ psoas sign indictes appendix is located ?

+ obturator sign indicates appendix is located ?

+ McBurney’s indicates appendix is located ?

A

Retro-cecal/peritoneum

Retrocecal
Pelvis

Iliac fossa

52
Q

? causes Torsades

? is the MCC of chronic gastritis

What is used for Triple and Quad Therapy

A

QT prolongation

H Pylori in antrum/body- Gram neg rod

3: Clarithromycin Omeprazole Amox (Metro)
4: Omeprazole Tetracycline Metro Bismuth

53
Q

? is the MC RF seen in esophageal adenocarcinomas

Biggest RF for Adenocarcinoma

Biggest RF for SCC

A

GERD

Barretts

Smoke and ETOH

54
Q

What two parts of the colon are most susceptible to ischemic colitis

? is the gold standard for Dx

What are the two ‘watershed’ areas of this condition

A

Splenic flexure
Rectosigmoid junction

Colonoscopy

Superior/Inferior mesenteric artery area
Inferior/Hypogastric artery area

55
Q

? is the proposed mechanism for developing non-alcohol fatty liver dz

? has proven to be the best Tx

What vaccines do they need

A

Insulin resistance

Weight loss

Hep A/B

56
Q

? amount of alcohol consumption is estimated to increase health risks

? is the MC systemic vasculitis

What causes the Sxs associated w/ this MC

A

Men: >14 drinks/wk
Women: >7 drinks/wk

GCA

Intima hyperplasia

57
Q

? is the two biggest RF for GCA

? other rheumatological dx is associated w/ this condition

What are two common lab results

A

Age, almost never <50
Scandanavian descent

Polymyalgia rheumatica- morning stiffness/ache in pelvis/shoulder girdles

Normochromic anemia
Normal leukocytes

58
Q

How is GCA Tx in Pts who can’t tolerate CCS

? is the best antiplatelet regiment for PTs having urgent PCI

How does this change if Pt is having nonurgent/elective PCI

A

Tocilizumab
Methotrexate

ASA and Prasugrel/Ticagrelor

ASA and Clopidogrel

59
Q

Bulk forming laxatives

Softener laxatives

Stimulant laxatives

Lubricant laxatives

Prokinetic laxatives

A

Psyllium Methylcellulose

Docusate

Senna Bisacodyl Castor oil

Mineral oil

Lactulose Sorbitol Polyethylene glycol

Tegaserod Metoclopramide

60
Q

Identified inferior MI, next best step?

? type of respiratory noises heard during asthma attack

How is pneumonia Tx if Pt has had ABX <90days

A

Repeat EKG w/ right sided leads

Expiatory wheeze

Fluroquinolone or,
Macrolide and Beta-lactam