Peds Block 2 Flashcards
What are the three categories of fever?
Short duration- localized S/Sxs; dx w/ history and PE
W/out focus- often kids <3y/o; Hx or PE fail to show cause
Unknown origin- Fever >8 days w/out identifiable etiology despite PE, labs or after 1wk of hospitalization
Teething kids usually don’t have a fever higher than ?
What are two main causes of Fever Without Focus/Source?
100.4*
UTI and pneumonia
Serious bacterial infections in neonates/infants are usually due to ? 3 things
What is the most and second most common microbe?
Bacteremia UTI Meningitis
E Coli*, GBS
HSV induced virus is considered if PT is febrile and younger than ?
Peds who appear well but with fever are more likely to have ?
<28days
Virus
Peds under ? w/ fever need to be evaluated by the ER and NOT given ?
Tachypnea= ? Tachycardia= ?
2mon, no antipyretics
> 60breaths pm
180bpm
How do you determine petechiae from other rashes?
All kids <1mon w/ fever w/out focus or source have what follow up step done
Petechiae= no blanching, more concerning
Admitted
CBC, culture, UA/culture, LP, CXR, stool WBC/culture if diarrhea is present
Post-labs: start ampicillin/gentamycin
Kids w/out fever but have toxic signs and are 1-36mon get
Admitted CBC, blood culture, UA/culture, LP (if 1-3mons and irritable*) Stool WBC/culture if diarrhea CXR if Temp >102.1 and WBC >20K Empiric Ceftriaxone or Cefotaxime
What are 2 common bacterial infections in kids?
Acute Otitis Media- bulging, erythematous, and non-mobile TM
Strep Pharyngitis- seen late fall/winter, uncommon <3y/o
Prevent heart complications w/ PCN
What are the female risk factors for UTIs?
What re the risk factors for males?
White, <1yr, 102.2* or higher, Fever 2 days or longer
Uncircumcised, nonblack, temp 102.2 for more than 1 day
What are the two main types of bacteremia?
What are the more common agents?
Source: pneumonia, cellulitis
Occult: +culture in well appearing child
Pneumococcus
H Influenza Type B
Define Fever of Unknown Origin
What’s the difference between FOUO and Fever of Known source?
Fever >100.4 no origin +8 days
Duration
PT >6yo w/ fever is usually due to ? while adolescents w/ fever are more likely due to ?
Preterm infants less than <32wks have not received all maternal ?
Low birth weigh babies can summon ? type of immune reaction?
Respiratory/GU
TB autoimmune IBD lymphoma
IgG- cross placenta during second half of last trimester via active transport
IgM
Define Sepsis and Severe Sepsis
Systemic Inflammation Response Syndrome
Severe= end organ compromise
Temp >101.3
Tachy >2SD for age or,
Hypoxemia <70mm room air
HR >2SD for age or,
HOTN <2SD for age or,
Cap refill >3 sec
Lactic acidosis
Oliguria
AMS
Bacterial meningitis will present with what type of opening pressure?
What type of defect cause kids to be susceptible meningitis?
What two PT populations are more likely to get Strep Pneumo meningitis infections?
High
C5-8 defects w/ spleen issues
Functional asplenic- sickle cell
HIV
How is meningitis transmitted and what PT populations may be more susceptible?
What PT populations are more likely to get N Meningitidis infections?
What 4 serogroups are in the MCV4 vaccine?
Respiratory tract secretion/droplet
Native American/Eskimo
Younger than 5y/o, 15-24y/o
A C W Y X (verify)
B- has own vaccine
A: MC in Africa
B: MC in US
HIB infections more common during what part of life?
N Meningitidis has what 6 serogroups?
N Meningitidis mengingitis presents w/ what 2 S/Sxs?
70% of cases in first 5yrs of life
Peak at 6-9mon
A B C X Y W-135
Pruprua + non blanching
Since ABX are usually started prior to obtaining an LP, what lab results can be elevated for days later?
Traumatic LP taps are less likely to affect Gram stain, culture and glucose but can affect what two results?
Pleocytosis w/ neutrophils
Elevated protein
Red glucose
Leukocytes and Protein
What are 3 meningitis DDx?
Partially treated bacterial meningitis
Encephalitis- changes in mental status, greater risk for seizures, global neuro abnormalties
CNS abscess- focal neuro signs, Dx w/ CT
What ABX for meningitis is recommended for kids outside of neonatal period?
Vancomycin w/ 3rd gen Ceftriaxone
Meropenem- PCN/cephalosporin allergy
L monocytogenes suspected= ampicillin
Imm compromised/gram neg microbe- Cefepime/Meropenem
Three potential complications of meningitis Tx
Which microbe causes the survivors to have sequelaes of deaf, seizure, blind or learning disabilities?
SIADH
Hearing loss
Subdural effusion w/ S Pneumo and H Influenza
Pneumococcal infection
What part of a meningitis presentation indicates a poor prognosis?
Define Encephalitis and the 3 types
Young Long duration Seizure/coma Shock Low/no CSF ImmComp PT
Inflammation of brain parenchyma causing dysfunction (post infxn, chronic degeneration, viral)
What are the most common cause of viral meningoencephalitis?
Picornaviridae- neonate (functionally immcomp) and ImmComp PTs
Arbovirus: arthropod vector, most are zoonotic
What does HSV1 cause?
What does HSV2 cause?
Sporadic encephalitis
Coma/death in 70% of PTs
Neonatal encephalitis vix vertical transmission
What is a common Sx at presentation of acute infectious encephalitis
PTs w/ suspected acute infectious encephalitis get what serological studies?
Seizure
Cat scratch dz- from kitten Lyme dz Epstein-Barr Arbovirus Mycoplasma pneumo
What test procedures is done for HSV, enterovirus and west nile during work ups?
What is done for Tx of viral encephalitis
PCR
No therapy except: HSV, Variclla, Cytomegalovirus, HIV
What viral CNS infection can have a severe sequelae if not Dx/Tx promptly?
Rubeola= ?
HSV
(Done w/ Lect 1)
Measles: koplik, cough, coryza (runny nose), conjucitibits ( Fever and 3 C’s)
Rubella= ?
Roseola= ?
German measles
Milder, Blueberry muffin baby
Exanthem Subitum/6th Dz
Fever, no fever, rash
(Subitum= sudden)
Varicella= ?
5th Dz= ?
Chicken pox
Dew drops on rose petals, itchy
Erythema infectiosum
How long/how are infants protected from measles?
What Dz can measles cause in Leukemia/HIV PTs?
Protected by transplacental maternal Ab until end of first year
Giant cell pneumonia
What is the most common complication of measles?
What is an acute but very late onset s/e?
Ottitis media
CNS: encephalomyelitis Sclerosing panencephalitis (8yrs later)
Humans are the only natural host for ?
How is it transmitted and how long are PTs infectious?
Rubella
Droplet
2 days before-7days after rash
Likelihood of Rubella infecting a fetus is highest at ? and lowest after ?
1st trimester
16wks
PT w/ Rubella develop a rash first where?
How does this rash spread?
Face/neck to torso but fades
Face during progression lasting for 3 days
Lymphadenopathy is more prominent in Rubella PTs than other viral infections, primarily involving ? lymph nodes
What oral finding will be seen?
Suboccipital
Postauricular
Anterior cervical
Rose colored lesions
What finding can be seen in female PTs w/ rubella?
What oral finding may be seen in Rubella PTs
Polyarthralgia of hands
Forchheimer spots 3 days before rash
How is Rubella Dx?
What unique finding is seen in CRS PTs?
Serological IgM, usually turns + 5 days after Sxs
IgM at 3mon
Stable/rises over 7-11mon
Rubella infecting babies creates CRS w/ ? issues?
Why are these PTs dangerous?
Deaf Cataract CHDz (PDA)
Secrete virus x 12mons
How is Rubella Tx?
When is this vaccination c/i?
How long after receiving MMR do females need to avoid getting pregnant?
Supportive
ImmComp/Supressed
Pregnant
Received Immunoglobulin in past 11mon
28days
When can post-exposure prophylaxis be given for Rubella?
What is the most common and accompanied Sxs of mumps
Within 3 days
Orchitis
Fever, Parotid swelling or tenderness
How is Mumps spread?
How long are PTs contagious?
Respiratory droplet
7 days before - after parotid swelling
What causes 5th Dz
Because this Dz has a high affinity for progenitor cells, what PT populations are at risk?
Parvovirus B19
Hemolytic anemias= aplastic crisis
Fetal anemia
Hydrops fetalis
How is 5th Dz transferred and what season is it seen in?
Because this present with vague URI/flu like Sxs, what key finding is indicative?
Respiratory secretion
Blood transfusions
Spring
Slapped cheek rash w/ circumoral pallor
What happens in each stage of development during 5th Dz?
What areas of the body are not affected by this virus?
1: slapped cheek
2: erythematous truncal rash
3: central clearance leads to lacy reticulated rash leading to desquamination
Palms/soles
How is 5th Dz Dx?
How is it Tx?
IgM, PCR
Hydration, antipyretic
Transfusion if PT has aplastic crisis
IV immunoglobulins if ImmComp w/ anemia or chronic infxn
What PT population will not develop a rash when infected w/ 5th Dz?
What part of pregnancy is most susceptible to this infection and to whom?
What two PT populations are at highest risk for 5th’s?
Transient aplastic crisis PTs
2nd trimester
Pregnant
Deficient blood production d/o
6th Dz is AKA ?
What causes this?
Exanthem Subitum
Roseola
HHV 6 and 7
When are most cases of Roseola seen?
How does this present?
95% w/ HHV-6 by 2yrs, peak is 6-9mon
Fever before rash
Sudden/abrupt fever 103.5
Maculopapular rose colored rash w/ defervescence
What is the sequence of spreading of Roseola rash?
What is the gold standard for Dx?
Trunk to face to extremities
Viral culture
How is Roseola Tx?
What complication can occur from this dz?
Hydration, antipyretic
ImmComp= Ganciclovir/Foscarnet
Encephalitis
Virus associated hemophagocytosis syndrome
How does Varicella get transmitted and where does it reproduce?
How long are these PTs infectious?
Airborne
Contact w/ eye/resp tract
Nasopharynx/UR tract
Until all lesions are crusted over
How does Varicella rash spread?
How does this rash look and what are the stages?
Trunk to head, face and extremities
All lesions stages at once (all lesions in same stage= smallpox)
Non-umbilicated oval tear drop vesicles w/ erythematous base and possibly on membranes
Vesicular-pustules-scabs
What is the most common complication with Varicella?
What other adverse events can occur?
Secondary skin infections from Staph/Strep
Pneumonia
Reye syndrome- avoid ASA and salicylates
What happens to neonates exposed to Varicella 5 days before/2 days after delivery?
What is used for Tx?
Neonatal varicella, no shingles
VZIG
IV immunoglobulin
When do Varicella PT get an anti-viral
Mortality from varicella increases if ? 2 things are present?
Acy/Valacyclovir
Unvaccinated +12y/o
Chronic skin/pulmonary dz
CCS/salicylate therapy
+20y/o
ImmComp
When do kids get Varicella vaccine?
What type of immunity does VZIG offer when used as post-exposure prophylaxis?
12-15mon
4-6yrs w/ MMR
Passive- given within 96hrs of exposure
Define Zoster
Can mothers w/ this outbreak continue to breast feed?
Recurrence of latent VZV from direct contact
Yes, but must cover and prevent skin on skin/direct transmission
Where does Zoster outbreaks usually occur?
What is an adverse effect?
Thoracic/lumbar w/ unilateral lymphadenopathy
CN7 Ramsay Hunt syndrome: facial paralysis and ear canal vesicles
What are two predisposing signs that a PT w/ zoster outbreak will have prolonged pain?
What zoster vaccine has the CDCs recommendation as the strongest level of protection?
Advanced age
Severity of pain at presentation
Shingix
Zostavax
How/what causes hand, foot and mouth?
How do PTs present?
Coxsackie A16 via fecal/oral route
Sore throat
Lesions hand>feet
Anorexia
Mouth pain
Where do young kids present with Hand foot mouth Sxs?
How is this Tx?
Diapered areas
Pain control and hydration
What is a s/e of having hand, foot, mouth dz?
What Sx do adults develop who get hand foot mouth?
Desquamation of nails, hands and feet weeks later
Oral lesions
What causes Scarlet fever
How does this rash start and spread
GAS
Starts at neck, spreads to trunk/extremities that feels like sandpaper but blanches w/ pressure
Peels like sunburn after resolution
PT presenting with Scarlet fever rash and a Pos GAS test gets ? med
Define Herpes Gingivostomatitis
Amoxicillin
Herpes of gingiva and vermillion border
Define Herpes labialis
How does this present?
Cold sore/fever blister
Skin/membrane of vermillion border, most common form
Erythematous papules progressing to groups of 2-4mm and fluid filled w/ erythematous base
Define Viral Paronchia
How can this be acquired
Herpetic whitlow
Herpetic gingivostomatitis
Define Herpes Gladiatorum
How are they treated?
Unique to wrestler/rugby
PO A/V/F-fyclovir
What is a rare but dangerous outcome from genital herpes?
What causes pinworms?
Aseptic (viral) meningitis
Enterbius Vermicularis- nematode/roundworm
How are pinworms Tx?
What is the most effective prevention method?
Pyrantel pamoate (alt)
Albendazole
Mebendazole (alt)
Hand hygiene
What causes scabies
How does it present?
Mite: sarcoptes scabei
Severe/paroxysmal itching
Linear papules in axilae, umbiilicus, groin, webbed spaces w/ 1-2mm red pappules
What part of the body is not affected by scabies?
What is the standard Tx and what is the most effective -cide agent?
Face
Permethrin cream
Heat
What is the most common chronic relapsing skin dz in infancy/children?
What type of FamHx is this related to?
Atopic dermatitis/eczema
Atopy (allergic rhinitis, asthma, eczema)
Define Atopic March
How does atopic dermatitis present?
Food allergy, Allergic rhinitis, Asthma
Itch that rashes/Bricks w/out mortar
Nocturnal pruritus and cutaneous reactivity= cardinal feature
How does atopic dermatitis present on infants?
Where does is present on older kids or chronic cases?
Face, scalp, extensor surface (spares the diaper)
Flexor folds, extremities
What finding is indicative a PT will have severe cases of eczema?
How is this condition Tx?
Outbreaks crossing flexor folds
Avoid triggers Liberal bland emollients Topical anti-inflammatory (Cornerstone= CCS) Warm baths w/ rapid lotion Baths w/ 1/4 cup of bleach
When are Topical Calcineurin Inhibitors used for Atopic Dermatitis
When are these sought out instead of earlier treatments?
Immune modulators for +2y/o
Pimecrolimus- mild/mod
Tacrolimus- mod/sev
Parent w/ steroid phobia
Face/neck dermatitis
What meds can be used as adjuncts for Tx of Atopic Dermatits?
1st Gen sedating anti-histamine (diphenhydramine, hydroxyzine) for sleep and reduced pruritus
Systemic CCS- failed topical, anticipate rebound flare ups when d/c
Derm referral: severe cases of UV therapy or Systemic Cyclosporine
Where does Secondary Impetigo come from?
How is it Tx?
Atopic dermatitis- Staph A or GAS
Topical localized- Mupirocin
Widespread- PO 1st Gen cephalosporin (cephalexin)
Define Eczema Herpeticum
How do these PTs present?
Eczema/HSV overlapping dz
(Kapsois Varecelliform)
Punched out/crusted over appearance
What is the only two reasons to prevent infant from trying peanuts at home?
What are the two sub-types of contact dermatitis and how are each Tx?
Egg allergy
Severe eczema
Irritant: remove agent (dirty diaper), Tx w/ CCS
Allergic:
How does Diaper Dermatitis w/ Candida present?
How is this Tx?
Secondary process causing
beefy red/pink skin w/ numerous pustules and satellite papules
Fist: Ointment/paste barrier w/ petroleum or zinc oxide
Hydrocotisone (short term)
Disposable diapers
Anti fungals: Nystatin, Clotrimazole
Dry skin dermatitis is AKA ?
How is it Tx?
Lip licker dermatitis
Erythematous/fissured in area of exposure
Stop offending action
Moisturizer cream
Steroids/topical ABX if refractory
Define Juvenile plantar dermatosis
How is it Tx?
Pre-puberty child w/ hyperhidrosis wearing occlusive foot wear
Emolient after removing socks/swimming
Severe: med/high topical steroids
Define Allergic Contact Dermatitis
How do they present
Cell mediated immune reaction, Type 4 or delayed/ type
Pink w/ sharp margins in weird patterns that have clear vesicles/bullae in middle
What are the DDx of allergic contact dermatitis?
What type of plants can cause allergic contact dermatitis?
HSV Dermatophytoses Impetigo Cellulitis
Rhus (poison ivy/oak)
What causes Seborrheic Dermatitis
How does it present
Malassezia yeast
ASx PT w/ circumscribed w/ well defined borders of scales/hyperkeratosis on face, neck, diaper, ubilicus
Seborrheic in infants usually presents as ?
How do adolescents present?
Craddle Cap
Hair loss, blepharitis, brown scaly areas w/ yellow crust
What is the difference between Seborrheic dermatits and Acute Dermatitis
How is infantile seborrheic cases Tx?
Seborrheic doesn’t self resolve, chronic relapses
Emolients/oil
Persistent: low CCS and topical anti-fungal
Ketonconazole shampoos
What is the first line Tx for seborrheic dermatitis in kids/adolescents?
Define Pityriasis Rosea
1st: Antifungal shampoo,
Topical CCS- Fluocinolone
2nd: topical calcineurin inhibs/keratolytic (urea)
Once resolved, 1/wk antifungal shampoo wash
Winter occurrence in adolescents as Herald Patch (on trunk/prox thigh), evolves into Christmas tree pattern parallel to skin tension lines
How is Pityriasis Rosea Tx
Define Psoriasis
Menthol/Camphor lotion
PO anti-histamine
Phototherapy
Papulosquamous rash, w/ plaque being most common
Sharp demarcation, irregular borders that turn “mica” like if UnTx
Where does psoriasis present
Define Auspitz sign
Scalp knees elbow Umbilicus
Ear canal
Kids- face, nail plate
Pinpoint bleeding w/ scale removal
Define Guttate Psoriasis
What usually precedes this presentation?
Mostly in kids
Eruption of oval/round papules on trunk, face, proximal limbs
Wks after strep infection
What is the foundation of Psoriasis Tx?
What can be used ad adjuncts?
Topical CCS
Vit D analogs
Salicyclic acid
What secondary therapy may help adolescents w/ Psoriasis?
What is used if extensive skin involvement is present?
Phototherapy
Immunosuppressives- Methotrexate, Cyclosporine, TNF antagonists
Define Erythema Multiforme
Who/when does this primarily affect?
First of several hypersensitivity syndromes
Target lesion: Red, white, purple ring w/ plaque/bullae on hands, feet, elbow, knee
Males in second decade
What are two predisposing factors that can cause Erythema Multiofrme
This often is the first of what following two issues?
HSV infection
Mycoplasma pneumoniae
Steven Johnson
Toxic epidermal necrolysis
Steven Johnson/Toxic epidermal necrolysis are most commonly caused by
How is it Dx
Drugs- NSAIDs ABX sulfonamide anticonvulsant
Infection- mycoplasma pneumo
Nikolsky sign- rub skin and sloughing occurs
How does early cases of Steven Johnson/Toxic Epidermal present
How is it Tx?
Swollen lips
Bilateral conjunctiva erosion
Genital mucus erosion
Stop agent
Support- feeding, fluid/E+
Burn unit
Ophthalmology
What is the most common skin d/o in adolescents
What are the 3 parts of this
Acne vulgaris
Hyperkeratosis
Inc sebum
Propionbacterium increase
What are the two types of acne?
Non-inflammatory comedomes:
Open/blackhead- open to air, superficial
Closed/whitehead- closed to air, deeper
Inflammatory comedomes:
P. acnes colonization that ruptures, appearing as papules, pustules, cysts
What is the mildest form of acne?
What area is most commonly involved in men/
Adolescent comedomes in central face
Trunk
What are the stages of acne?
1: comedomal, minimal papules and occurs w/ puberty or 1wk prior to menses
2: papules on face only
3: pustules w/ scarring and possible cysts
4: nodulocystic acne, scarring and cysts
What topical agent is 1st line therapy for acne Tx?
What drugs does this line of therapy encompass?
Comedolytic agent: Retinoid x 6-8wks, will worsen before it gets better
Dec keratin/sebum/inflammatory
MOST effective monotherapy
Tretinoin Adapalene Tazarotene Salicylic acid Azelaic acid
What are the major s/e of using retinoids for acne?
When are PO ABX treatments used for acne?
Irritation
Adapalene- minimal
Tretinoin- red and scaling
Taza- only irritation
Mod/Sev/Inflammatory resistant to topicals
Doxy, Mino>tetracycline
What is the s/e of taking PO ABX for acne?
What med is used w/ systemic ABX and for maintenance after completing AB regime?
Pill esophagitis due to routine lasting for 3mon
Benzoyl peroxide or retinoid
What education piece has to be done when prescribing Isotretinoin for acne?
What OCPs can be used for acne?
Tetratogenic agent
Triphasics- Orthotricyclen has FDA approval for acne
When using OCPs for acne, what do they have to be low in?
What would be the benefit of prescribing Yasmin/Yaz?
Progestin
(Norgestimate, Desogestrel, Levonorgestrel)
Progestins that are spironoloactone analogs w/ antiandrogenic effects
Where are giant congenital pigmented nevi usually seen?
What are two outcomes that need to be monitored for?
Posterior trunk
Head/extremeties
Neuromelanosis- melanocytes in CNS
Malignant melanoma- cutaneous or neural
What is the most common type of cancer is kids?
When are nodal metastases seen and what does that indicate?
Melanomas- white females 15-19y/o on extremities/heads of males
More likely to occur in younger kids, not associated w/ decreased survival
Adolescent w/ nodal dz- significant negative prognosis
What are the ABCDEs of pediatric derm?
How do peds melanomas usually present?
Asymmetry Boders Color Diameter >6mm Evolving
Amelanotic
More likely- regular borders and less than 6mm in diameter
Papules/papulonodules
Define Pyogenic Granuloma
Where are they most commonly seen?
What is the definitive Tx?
Pink/red popular lesion after trauma, grow rapidly in weeks
Bleed a lot if damaged
Head, neck, UE
Surgery