IDz Block 3 Cram Flashcards
What happens during the prodromal period of rabies infection?
What occurs during the acute neurological period?
What finding during the neurological period is pathgnomonic
Virus enters CNS
Pain/paresthesia= pathognomonic Dx
Furious rabies
Paralytic rabies
Hydrophobia
Aerophobia
What is the passive immunization for rabies Tx
How often is rabies booster recommended?
HRIG 20IU/kg in gluteus away from bite
CDC- 2yrs
WHO- 1yr for oversea operators
What may be the first sign of septic arthritis in PTs w/ RA?
What are the two types of osteomyelitis
Septic bursitis
Acute/Chronic
Acute- w/in 2wks bacteria deprive bone of blood, causing necrosis
Chronic- repeat infections and dec blood supply prevent ABX reaching site
What ABX is used for PTs w/ osteomyelitis after nail punctures through shoes?
Define Rickettsiae orgnaism
Cipro
Between bacteria/virus, obligate intracellular Gram-neg coccobacilli
What ABX is used for PTs w/ osteomyelitis after nail punctures through shoes?
Cipro
Since Rickettsiae don’t stain well w/ gram stain, how are they stained for identification?
Rickettsiae are usually transmitted to humans by arthropods except for ?
Red w/ Giemsa
Q fever
Rickettsial Dzs have ? commonalities?
Different types of Rickettsial Dzs
Dx w/ serology/PCR Rash Zoonotic Involve endothelial lining Tx w/ Doxy
Brill Zinsser Louse borne Murine Typhus RMSF Q-fever
Louse Borne Typhus is caused by ? and transmitted by ?
This form is becoming resistant to Doxy in Thailand, what med is used now?
Caused- R Prowazekii
Carried- P Humanus
Azithromycin
How does Louse Borne Typhus present?
What is the sequence of the rash progression?
Intractable HA
Rash from trunk to extremities (opposite of RMSF), spares face palms soles
Macules Maculopapules Petechiae
? is a relapsing louse borne typhus
How does it present
Brill Zinsser
Fever Transient rash HOTN
M Typhus is AKA ?
What causes this strain?
What is it’s carrier?
Endemic/Flea borne typhus
R Typhi
Rat flea
What is the biggest differential between Murin and Louse borne typhus?
What causes RMSF?
What is it’s carrier?
Brill Zinsser
R Rickettsii
Wood/dog ticks
What is the day to day progression of a Rickettsial Dz
1-2: abrupt high fever/HA
2-4: rash on wrist/ankle, spreads centrally
5-7: high fever, rash become petechial involving palms/soles
7-9: digit necrosis, death AMS
What will lab results of Rickettsial Dz show?
How is it Tx?
HypoNa
Inc transaminase
Thrombocytopenia
Doxy, best if started <5 days of Sxs
What causes Q-fever
This has been re-classified as a ? microbe
C Burnetti
Proteobacteria
What is the mainstay of Dx Rickettsial Dzs
What causes Lyme Dz
What is it’s carrier?
Serology cross reactivity
Spirochete- B burdorgeri
Ixodes- deer tick
What is the characteristic PE finding of Lyme Dz
What are the S/Sxs of early disseminated Lyme dz
Lyme Dz can cause ? manifestations of cranioneuropathy
Erythema Migrans
Multiple EMs
Meningismus= eseptic meningitis
Carditis- AV blocks
CN7, Bells
If Lyme Dz PT develops late dz arthritis, how does it start out
What joints are most to least likely affected
Most PTs exhibit these Sxs within ?mon of Erythema Migrans and resolve w/in ?
Migratory polyarticular process
Knee Ankle Wrist
6mon
10yrs
If Lyme Dz PT develops late dz arthritis, how does it start out
What joints are most to least likely affected
Most PTs exhibit these Sxs within ?mon of Erythema Migrans and resolve w/in ?
Migratory polyarticular process
Knee Ankle Wrist
6mon
10yrs
What are 3 possible long term outcomes that can arise from late Lyme Dz arthritis
If PT has Lyme and is pregnant, what meds are not used?
How should these PTs be educated?
Meningoencephalitis
Fibromyalgia
Chronic fatigue
Chronic neuropathy
Doxy
Tetracyclines
No birth defect, risk of still birth
How is Lyme Dz Tx
Bite w/ engorged tick: Doxy
Arthritis: Doxy
Palsy: Doxy
Tick, non-endemic: no Tx
Erythema Migrans: Doxy/Amox
Carditis: Doxy/Ceftriax
Meningitis: Ceftriax
Pregnant: Amoxicillin
How is Lyme Dz Tx
Bite w/ engorged tick: Doxy
Arthritis: Doxy
Palsy: Doxy
Tick, non-endemic: no Tx
Erythema Migrans: Doxy/Amox
Carditis: Doxy/Ceftriax
Meningitis: Ceftriax
Pregnant: Amoxicillin
How is encephalitis Dx
What sample is essential for Dx
Head CT w/ and w/out contrast but before LP
CSF
Where does HSV lie dormant prior to causing HSV encephalitis
How does the virus reach the CNS
This form of latent HSV is not associated w/ ?
Trigeminal ganglia
Olfactory tracts
Cold sores
Where does HSV lie dormant prior to causing HSV encephalitis
How does the virus reach the CNS
Trigeminal ganglia
Olfactory tracts
What are the subacute form of HSV Encephalitis
This can also produce ? inconvenient issue?
Anterior opercular syndrome- benign recurrent meningitis, loss of facial/chewing muscles
HSV-1: brainstem encephalitis
HSV-2: encephalitis induced myelitis
Global aphasia
How is encephalitis Dx
How is it Tx
PCR
CT- low density lesions in temporal lobes on day 3-4
Acyclovir
Majority of Arbovirus encephalitis is ? type
How does Arbovirus encephalitis present differently?
What will be seen on labs?
West Nile
Dys/pyuria
Seizures
Movement d/o
Leukocytosis
EEG changes
Majority of Arbovirus encephalitis is ? type
How does Arbovirus encephalitis present differently?
West Nile
Dys/pyuria
Seizures
Movement d/o
How does West Nile Encephalopathy present?
How is it Dx
Extreme lethargy
Flaccid paraylsis
Leukpenia and serology
What are the 3 major pathways meningitis establishes an infection?
What 3 microbes cause bacterial meningitis
What microbe causes meningitis in adults and kids?
Bloodstream
Retrograde neuron pathway
Direct spread
H Influenza
N Meningitidis
S Pneumoniae
S Pneumoniae
What meningitis triad presents in most PTs
What do PTs present w/ if there is cerebellar dysfunction
Fever
AMS
Nuchal rigidity
Lethargy
Confusion
Coma
What are the two PE tests for meningitis
How do geriatric PTs w/ meningitis present differently
What is a subtle Sx of meningeal infection that may be seen?
Kernig
Brudzinski
Lethargic, no meningeal Sxs
Neutropenia
What are the two PE tests for meningitis
Kernig
Brudzinski
How is Step Pneumo meningitis Tx
What vaccine prevents this?
Cefotax/Ceftriax + Vanc + Dexameth
PCV 13
What is the MC causes of meningitis in neonates
How is Step Pneumo meningitis Tx
What vaccine prevents this?
GBS
E Coli
Listeria monocytogenes
Cefotax/Ceftriax + Vanc + Dexameth
PCV 13
What type of microbe is N Meningitidis
What presenting finding does it have and puts PTs at risk for ?
What PT population is more susceptible to being infected?
Gram neg diplococcus
Petechial rash
Amputations
Asplenic
How many serogroups of N Meningitidis are there?
Which one is more common in the US than out of it
How are they Tx
A B C W X Y
B
Cefotax or Ceftriax + Vanc + Dexameth
What is the criteria for close contact of N Meningitidis
What meds are used for post-exposure prophylaxis
> 8hrs of contact
<3ft away
Direct PO secretion exposure
W/in 1wk before Sx onset
Ceftriaxone 250mg IM x 1or
Rifampin 500mg PO bid x 4
Cipro 500mg PO x 1
What is the criteria for close contact of N Meningitidis
What meds are used for post-exposure prophylaxis
> 8hrs of contact
<3ft away
Direct PO secretion exposure
W/in 1wk before Sx onset
Ceftriaxone 250mg IM x 1or
Rifampin 500mg PO bid x 4
Cipro 500mg PO x 1
What are the 5 types of fungal infections that can cause meningitis
What are the two ‘special’ causes
C neoformans C immitis B dermatidis Candidiasis H capsulatum
TB Syphilis
What are the 3 proteinaceous infections?
What is an odd method of acquiring prion related Dzs
Kuru Jakob Bovine spongiform
Inherited
When do prion dzs present
How are these dzs Dx
6-7th decade as progressive dementia
MRI- bilateral areas of increased density
CSF- inc protein
What is the MC microbe in cat bites?
What is the MC microbe in dog bites?
Pasturella multocida
Capnocytophaga conimorsus
What microbe causes CSDz
This microbe is the MC cause of ? in Peds
It is also the MC cause of ? Sx
Bortonella henselae in fleas
Chronic adenopathy
Regional adenopathy
What is the classic presentation of CSDz
What nodes are most likely to present w/ lymphadenitis
Half of PTs can present w/ ? odd presentation
Rash
Lymphadenitis
Axillary
Cervical submandibular preauricular
Single node involvement
Atypical presentations of CSDz can present as ?
CSDz manifestations may be slow to appear and take ? long to disappear
Encephalitits
+12mon
How is CSDz Dx confirmed
How is it Tx
Serology
Sx therapy
Azithromycin
What causes Toxoplasmosis
How is this infection transported and disseminated
Toxoplasma gondii
Transport- lymphatics
Disseminated- hematogenously