MPH Block 1 Review Flashcards
Define Herd Immunity
Indirect protection from infectious disease for those that are not immune
Only applies to contagious diseases
Define Herd Immunity Threshold
When a disease is no longer persistent in a population due to a critical proportion of the population is already immune
Define Basic Reproduction Number
Average number of new cases caused in a susceptible, well mixed population
What are examples of microbes that are transmitted through Direct Contact and Droplet transmission
Contact- Herpes, Syphilis, Hookworm
Droplet: travel short distance, less than 1meter but are not suspended in the air- Pertussis, Meningococcal, Mumps
What are microbes that are passed through Indirect Vehicle and Vector (mechanical/biological) transmission from reservoir to host?
Vehicle Borne= Food, Water, Fomites: Salmonella, HCV, MRSA
Vector Borne-
Mechanical- Shigellosis/Bacillary dysentery, Plague
Biological- Malaria, Dengue
What are examples of microbes that are passed through airborne transmission?
TB
Measles
What types of PTs are screened for gonorrhea and chlamydia?
ASx Abstinence Monogamy Barrier methods Alternative methods
HPV screening is recommended to start at what age but can be done as young as ?
11-12
9
What age of PTs can have catch up HPV vaccines?
Both genders ages 13-26 who have been previously vaccinated or have not completed the series
Can PTs 27-45y/o receive HPV vaccine?
What is NOT considered a contraindication?
Yes, if it’s a shared clinical decision
Hx of HPV, abnormal PAP, or genital warts
How old can non-immune compromised PTs receive the HPV vaccine?
2 doses prior to 15th birthday
On or after 15th birday- 3 doses
What is the STANDARD schedule for receiving pneumococcal vaccines?
PCV13 @ 2, 4, 6, 12-15 months
PTs with chronic conditions such as DM, heart Dz or lung Dz should get what form of the pneumococcal vaccine?
PPSV 23
Immune compromised PTs w/ HIV, asplenia, chronic renal failure nephrotic syndrome get what form of the pneumococcal vaccine?
PCV13 8wks PPSV23 5yrs later PPSV23
What form of the pneumococcal vaccine can pregnant women receive?
PPSV 23
What schedule of pneumococcal vaccines should PTs with CSF leak or cochlear implants follow?
PCV13
8 wks later
PPSV23
Define VAERS
Unified national system to collect, manage and evaluate reports of possible adverse events that occur after the administration of a US licensed vaccination
What vaccine products are given first or at what timeline?
Live vaccine- 2 wks before Ab
Ab/Ig- wait 3+mon then give vaccine (except yellow fever and zoster)
PPD- give live vaccine when PPD is read
Live vaccine- wait 4-6wks to apply PPD
What is the administration interval for combo vaccines?
2 inactivated, Inactivated and Live, Oral and Injectable live vaccines- no interval
Two life injected vaccines- 4wks (except yellow fever, can be given <4wks after measles)
What are 3 additives found in vaccines?
Adjuvant
Preservatives
Residual materials
Define Adjuvant and 3 examples
Substance, primarily Alum, used to enhance vaccines and reduces number of active components and doses needed due to enhancement
What are 3 examples of Adjuvant used in vaccines
Shingris
Heplisav
FLUAD- squalene based oil-water emulsion
What are the functions of preservatives in vaccines?
Maintain potency and sterility of multi-doses
What are 3 examples of preservatives found in vaccines?
Thimerosal
Formaldehyde
MSG
Phenoxyethanol
What is the function of residual materials in vaccines?
What are 3 examples
Used to grow virus/bacteria contained in vaccine
ABX, egg protein, gelatin
What are the 3 types of prevention?
1- Prevent onset of illness before dz process
2- leads to early Dx and rapid Tx
3*- Reduces morbidity/mortality from existing Dz (most of what occurs in medical treatment)
What is the gold standard of testing a respirator?
Use test
Significance of OSHA, CFR, EO 12196, and DODI 6055
OSHA 1970- Primary federal law governing OccHealth
29 CFR 1910 1960- labor laws governing work environment
ExOrder 12196 1980- required OSHA compliance, military exempted (noise on battlefield)
DODI 6055.5-M- minimum standards for medical surveillance/work place exposure health risks and hearing conservation
Define Communicable Period
Period of time during which infectious agents may be transferred from person/animal to susceptible host
Define Incubation
Time interval between infections and initial onset of clinical illness/Sxs and when a person can transmit the infection w/out showing and signs of the Dz
Define Latency Period
Time from infection to infectiousness, shorter than the incubation period
When is a member placed on into the hearing conservation program?
> 85dB
8hr TWA
140dB peak
STS of 10dB avg from 2k, 3k and 4k in either ear
What are the reproductive workplace hazards?
Blood- HIV and hepatitis
Airborne- Rubella, V-Zoster
Physical hazards not specified by OSHA- Vibration ranges of 5-10hz
Exposure to lead, ethylene oxide, waste anesthetic gases, mercury
What is the criteria for a reproductive protection deferral
Job description indicates exposure to teratogenic, fetotoxic or reproductive toxic substance AND worker indicates attempts to conceive OR
Female currently pregnant/breast feeding
What is the key to treatment for diarrhea diseases during a disaster?
PO fluids that are glucose/Na ratio equivalent
Total osmolality between 200-310 mOsm/L
What are the 3 vaccination immunity types?
Active- Abs in response to exposure/vaccine and leads to memory
Passive- Abs transferred from mother to baby as immune globulins, no memory.
Herd- no Abs, no memory but those around have the Abs and prevent Dz from growing/passing
Criteria for Mild Traveler’s Diarrhea and how is it Tx
Tolerable, no distressing and doesn’t interfere w/ planned activities
Use Loperamide or Bismuth Subsalicylates
Criteria for Moderate Traveler’s Diarrhea and how is it Tx
Distressing or interferes w/ planned activity
May use Loperamide alone or
Adjuvant w/ AB and +/- ABX
Criteria for Severe Traveler’s Diarrhea and how is it treated?
Incapacitating or prevents planned activities
May use Loperamide as adjuvant to ABX and should use ABX
Acute Traveler’s Diarrhea is treated how?
When is microbiological testing recommended?
Empirically
Severe or persistent Sx or those who fail empiric therapy
When is multiplex molecular diagnostics preferred?
All dysentery is considered ?
PTs with persistent or chronic Sxs
Severe
Characteristics of using Azithromycin
1g or 500mg PO- if Sx don’t resolve in 24hrs, continue daily dosing x 3 days
Use empirically as 1st line in SE Asia/India to cover fluoroquinolone resistant Campylobacter or areas if Campylobacter/resistant ETEC are suspected
Preferred regiment for dysentery or febrile dysentery
Characteristics of Rifaximin
Do not use if suspected Campylobacter, Salmonella, Shigella or other causes of invasive diarrhea are present
How are vector borne disease prevented?
PPM- sometime only effective protection and ALWAYS first line of defense
Vector control- impractical, logistics, time
Prophylaxis/Vaccines
What protective measures are taken for bug protection?
Full protection require each layer ACU permethrin DEET/picardian repellent on skin Wearing of uniform Sleep in permethrin netting
Permethrin treated netting doesn’t stop what bug that carries what disease?
Sand fly- causes leishmaniasis
Function of DEET
N,N-diethyl-meta-toluamide
Repels biting bugs such as mosquitoes, ticks, chiggers, fleas and flies
Applied before face paint
Apply sunscreen then DEET
Characteristics of permethium
Insecticide in pyrethroid family
Odorless/non-irritating
Prevents mosquito bites through fabric by killing/repelling insects that contact fabric
What is the MOA of permethium
Inhibits Na channels causing bugs to spaz/paralysis to death
What are the benefits of STI screening?
Female- reduce risk of PID/infertility
Male- reduce risk of reinfecting partners or overall transmission
Lower long term sequals
What are the 5 Ps of conducting a sexual Hx?
Partners Practices Protection from STDs Past Hx of STDs Prevention of pregnancy
What is the difference in disease prevalence from 1900s to 2010?
Where is the biggest decrease seen?
1910- TB and Pneumonia/Influenza
2010- CA and heart dz
Biggest decrease in infectious disease deaths
Altitude Sickness Sxs are caused by ?
Mild/Moderate hypoxia occurring above 8000ft
What are the less severe, more common Sxs seen in travelers w/ acute mountain sickness?
HA, fatigue, loss of appetite, nausea, insomnia
What are the two severe forms of Mountain Sickness?
High altitude pulmonary edema
High altitude cerebral adema
What meds can be used as prophylaxis for Mtn Sickness?
How is Mtn Sickness treated?
Acetazolamide 250mg BID starting 24hrs prior to ascent and continued for 48hrs at highest altitude
Tx= Acetazolamide 250mg BID
Numbness, tingling in extremeties, inc urination
What are the prophylaxis recommendations for PTs with and without Hx of Mtn Sickness/
Hx- considered for 8-9K ft and recommended if +9Kft
AHx- considered 9-11k ft and recommended for +11.5K ft
Suspected or confirmed cases of ? are considered medical emergencies
Malaria, especially P Faliciparum
When are malaria exposure risks the highest?
Dusk, dawn and night
What are the two stages of malaria?
Blood- clinical manifestations of Dz
Liver- hypnozoites, dormant stage (Vivax, Ovale)
When are kids 6-11mon and +12mon that are traveling OCONUS given vaccines?
6-11mon= 1 MMR followed by 2 doses after 1st birthday \+12mon= 2 doses separated by +28 days
When can suppressive meds be used for malaria?
Only effective at killing parasites in erythrocytic/blood stage
Provides relief of S/Sxs
What is the regime for taking Doxy for malaria?
Take 1-2 days prior to travel
Daily while in area
For 4wks post travel to kill parasites
What is the benefits of taking Tafenoquine for malaria?
What is the screening and dosing requirement?
Prevents parasite development in liver and active against blood and dormant liver stage parasites
Reqs G6PD screening
PART dosing 300mg x 1
What medication is most effective at preventing P Vivax?
What is the screening and dosing requirement?
Primaquine
Active against dormant liver stage
G6PD screening
PART dosing 52/5mg qday x 14
What is the risk of taking Malarone for malaria?
Doesn’t kill dormant liver stage
What are the four infectious sources of mortality consistently associated with humanitarian emergencies?
Diarrhea
ARI
Vectore-borne- malaria
Measles
In all suspected and confirmed cases of measles, treatment involves ?
Vitamin A- immediately up Dx and the next day
What is measles’ Ro and HIT?
What is pertussis’ Ro and HIT?
12-18, 92-95%
12-17, 92-94%
Who is considered high priority for getting a measles vaccination?
Refugees
How is Salmonella Typhoidal transmitted?
Fecal/urine contamination of food/water
How often is typhoid vaccine given?
Vi Capsular Polysaccharide given >2wks prior to travel and booster q2yrs
What is the PO typhoid vaccine schedule?
Live attenuated vaccine
4 capusles taken q other day >1wk prior to travel
Must be kept refrigerated, take with cool liquid 1hr prior to meal or 2hrs post meal
Booster q5yrs
What are the common characteristics of pre-formed toxin ingestion?
N/V Watery diarrhea 6hrs post-ingestion Resolves in 24hrs From improper processing, storage, handling of food
Characteristics of Clostridium Perfringens
One of the most common causes of food poisoning in US
Cooking kills cells, not spores
Causes diarrhea, cramps but NO fever or vomit and isn’t passed from person to person
Characteristics of Bacillus Cereus
Emetic from food cooked for insufficient time/temps to kill spores then improperly refrigerated
Causes N/V 1-5hrs post consumption
What bug carries Dengue?
Aedes mosquito- daytime mosquito (Aedes aegypti, Albopictus)
What protective measures are available for Dengue?
Dengyvaxia
Supportive care only
Where is Dengue a risk?
Re-exposure increases risk of ?
Urban areas
Dengue rheumatic fever
What are the recommendations of USPSTF?
A- recommend, substantial benefit B- recommend, moderate benefit C- against D- against, mod-high risk I- insufficient evidence, balance of harm/benefit can't be determined
What is the NMCI methodology for assessing disease risk?
Realistic Max rate + Disease endemicity= Potential attack rate in troops
Potential attack rate + typical severity= risk (red, amber, green)
Assessing disease risks of STIs
GC/Ch: women 24 and younger, older @ higher risk Men- considered class 1, insufficient evidence
How is screening for STIs in men accomplished?
Nuclear Chemical Acid Amplification Testing NAAT on urine or urethral swab
How is screening for STIs in women accomplished?
NAAT on vaginal swab or endocervical swab
Conjunctival Anne rectal swab are equal or better than other methods
What are the Suppressive and Causal meds used for malaria?
Suppressive: Doxy, Mefloquine, Choroquine
Provides clinical cure and relieves Sxs
All suppressive meds are taken with Primaquiine for presumptive antirelapse treatment for Plasmodium sp.
Casual: Tafenoquine, Primaquine, Malarone- only one not requiring G6PD screening and still uses Primaquine for PART
Suppressive malaria meds have what effect compared to causal meds that have ? effect?
Suppressive- kills RBC stage
Causal- kills blood and liver stages
Prophylaxis for Traveler’s Diarrhea is not recommended except for in ? type of PTs and ? med is recommended
Crohns
UC
Chronic Diarrhea
Rifaximin is DOC
What medication is used against leptospirosis
Doxy 200mg, single weekly dose
What two microbes in this block is there no vaccine for?
Campylobacter
Leishmaniasis
Define Incidence
Number of new Dz cases occurring in a specific time period in a population
Measure of risk, is a ‘rate’ and must have an element of time in denominator
Rate and element of time in denominator
(# new cases/avg population at risk during time)
Define Incidence Density
All people not followed for same amount of time
Number of new events per person-time