Oncology Flashcards
Carcinomas are cancers that start ?
Sarcomas are cancers that start ?
Leukemias are cancers that start ?
Skin/organ lining (breast/lung)
Bone Fat Cartilage Muscle Vessel CT/Support tissue (osteosarcoma)
Marrow causing abnormal cells to be released
What are the five prefixes of benign tumors?
What are the six prefixes of malignant tumors?
Chondroma- cartilage Andenoma- glandular Papilloma- epithelial Osteoma- bone Fibroma- connective tissue
Hepatoma- liver Melanoma- melanocyte skin Sarcoma- tissue around joint Leukemia- blood Lymphoma- lymph tissue Carcinoma- epithelial
What are the three methods metastases spreads in the body and what type is usually found by each?
Seeding- ovarian
Lymph- typical for carcinoma
Hematgoenous- typical for sarcoma; usually to liver/lungs
Define Proto-Oncogenes
Define Oncogenes
Codes proteins that stimulate cell division
Cancer causing gene:
Mutation stimulates unregulated/early division
Define Tumor Suppressing Genes
What happens when these genes are mutated?
How do Proto become mutated to Oncogene?
Code proteins to suppress oncogenes (cell division)
No inhibition= cancerous growth
Carcinogens: Chemical UV radiation Virus
What are the hallmarks of Ca that are needed for it to develop and survive?
A TRAGEDIES Activating metastasis Tumor promoting inflammation Resisting death Avoiding destruction Genome instability/mutation Evading growth suppressors Deregulating energetics Inducing angiogenesis Enabling immortality Sustained signaling
Basic Oncology focuses on ? three Dz parts and is instrumental in ?
What are the top three leading causes of death in the US?
Patterns, Cause, Effect
Screening, Prevention, Txs
Heart Dz
Cancer
Chronic lower respiratory dz
Only three forms of Ca that are not decreasing in prevalence or death rates?
What forms of Ca remain in the same location of developmental probability between M/F genders
Esophageal Pancreatic Hepatocellular
Lung/bronchus
Colon/rectum
Melanomas of skin
Non-Hodgkin lymphoma
What are the top three RFs of cancer for men and women
What are the prevalence of Brca mutation and Ca
Smoking Obesity Alcohol
BRCA-1: 85% breast, 50% ovarian
BRCA-2: fe/male breast, ovarian, prostate Ca
What are the different types of MEN
What is the difference between Wermer and Werner
MEN 1: Wermer Syndrome; MC, mutated menin gene
MEN 2: Sipple syndrome; mutated ret gene
MEN 3: mutated ret gene
MEN 4: mutated CDKIN1B gene
Wermer- MEN 1
Werner- premature aging
How does MEN 1 present
What is normal life expectancy
Hyperparathyroidism GEP-NETs Pituitary adenomas Insulinomas Gastrinomas
55yrs
How does MEN 2 present
Medullary thyroid carcinoma
Hyperparathyroidism
Pheochromocytomas
Hirschsprung Dz
Alcohol is linked to ? forms of Ca
Although associated w/ breast Ca, what is the catch w/ alcohol induced Ca?
Head Esophageal Liver Neck
Abstinence not linked w/ reduced risk
Radiations are linked to ? types of cancer
Radon is linked to ? type
Vinyl chloride is linked to ? type
Leukemia Breast Thyroid Lung
Lung
Hepatic angiosarcoma
Benzene exposure is linked to ? types of Ca
UV light is linked to ? types of Ca
AML Lymphoma
All types of skin cancer
USPSTF recommendations for breast Ca screening
Colon Ca screening for average risk PTs?
Mammography q2yrs 50-74y/o w/out S/CBE
Start at 50y/o, q10yrs w/ colonoscopy
Start AfAm/NAFLDz PTs at 45y/o
When are colon cancer screenings recommended for PTs w/ +FamHx
One FDR or 2+ SDR Dx >60, start at 50
One FDR or 2+ FDR Dx <60, start at 40 or 10yrs prior to Dx, what ever if first
q5yrs there after
What are the US PSTF grading criteria for expected benefit?
A: substantial, offer
B: moderate, offer
C: small, selective PTs
D: harms out weigh/no benefit, discourage
I: insufficient evidence to assess harm/benefit
What are the 4 methods of direct visualization for GI oncology?
What are the 3 stool based oncology tests?
Colonoscopy- q10yrs
Flex sig w/ FIT- q10y, FIT q1yr
CT colonography- q5yrs
Flex sigmoid- q5yrs
gFOBT: q12mon
FIT: q12mon
FIT-DNA: q1 or 3yrs
What age groups are eligible for PSA screening and what age groups are not recommended for screening?
What groups are cervical cancer screenings not recommended?
55-69: recommend, Grade C
+70: not recommended, Grade D
<21, >65, post-hysterectomy
How often are cervical cancer screenings conducted?
21-29: q3yrs w/ cytology
30-65: q3yrs w/ cytology or,
q5yrs w/ only hrHPV or,
q5yrs w/ hrHPV and cytology
When is lung cancer screening conducted?
55-80y/o w/ 30+ p/year or quit <15yrs: Annual LDCT (Grade B)
Stop once PT has quit for >15yrs or develops health problem that limits life expectancy/ability for surgery
Define Grading
Define Staging
Degree of differentiation based on pathology (1-4) w/ description
More predictive:
Severity and metastases; Estimates prognosis/guides Txs
What are the sub staging of T
T= tumor size TX= cannot be evaluated T0= no primary evidence Tis= carcinoma in situ; early, no spread T1-4= primary tumor size (small to large)